Despite significant advances in the measurement of state fragility, existing assessment frameworks remain primarily descriptive, identifying symptoms of institutional weakness without adequately explaining the systemic interactions that generate national vulnerability. Dominant approaches, including the Fragile States Index and state capacity measures, typically aggregate indicators of political instability, economic decline, insecurity, and governance deficits but provide limited guidance for diagnosing the underlying mechanisms that inhibit national adaptation and regeneration. This article introduces the Nationesis Diagnostic Matrix (NDM), a complexity-based diagnostic framework grounded in the theory of Nationesis. Rather than measuring fragility as a static condition, the NDM conceptualizes fragility as an emergent property of interacting failures across institutional, cognitive, social, ecological, economic, technological, and symbolic systems. The paper develops the theoretical foundations of the matrix, proposes its multidimensional architecture, explains its diagnostic methodology, and illustrates how it can support adaptive governance, institutional reform, and strategic policy design. The NDM complements the Nationesis Index by shifting analytical attention from measuring regenerative capacity to identifying the systemic constraints that prevent political communities from achieving long-term transformation.