Digital technologies have revolutionized the business environment and given Small and Medium-sized Enterprises (SMEs) in Africa new opportunities and challenges. The study explores approaches for African SMEs to harness digital ecosystems for revenue generation, cost savings, and business resilience. The study synthesises findings from a systematic narrative review of 54 peer-reviewed academic sources and 12 institutional reports, to examine how digital ecosystems evolve, their global manifestations and their unique characteristics in Africa. Key themes covered include the mobile-technology as the gateway to digital space in Africa, the evolution of Fintech and Agritech ecosystems, the impact of government policy and regulation, and persisting structural challenges to SMEs' digital participation, such as lack of access to finance, digital literacy gaps, and infrastructure gaps. The case studies of M-Pesa, Farmcrowdy, Twiga Foods, and Flutterwave provide evidence of the potential for a digital ecosystem to have tangible business impacts. Finally, the study outlines a policy framework and roadmap for digital transformation in the SME sector and recommends actions to be taken by governments, development partners, financial institutions, and the private sector.