In resource-constrained settings, structural and material inequalities shape children’s developmental opportunities, yet developmental pathways remain diverse even within shared hardship. This study examined developmental continuity and variation in cognitive trajectories among children born in adversity and assessed whether maternal structural positioning and household material conditions were associated with developmental progression. Data were drawn from 742 children born to adolescent mothers in the large longitudinal cohort in the Eastern Cape, South Africa. Cognitive functioning was assessed using the Mullen Scales of Early Learning (MSEL) at baseline and the Kaufman Assessment Battery for Children (KABC-II) at follow-up. Baseline functioning predicted later cognitive placement, indicating developmental continuity (B = 0.074, SE = 0.030, p = .015). Lower maternal educational attainment was associated with more constrained developmental progression (B = −0.097, SE = 0.023, p < .001), and maternal not in education, employment, or training (NEET) status also predicted constrained trajectories (B = −0.200, SE = 0.049, p < .001). In contrast, consistent access to basic household necessities was associated with more favourable developmental trajectories (B = 0.024, SE = 0.009, p = .012). These findings indicate that variation in children’s developmental trajectories reflects differences in structural positioning and household material conditions. Supporting adolescent mothers’ engagement in education and access to stable resources may represent an important pathway for improving child developmental outcomes.