Background/ Objectives: Burn care remains a major clinical challenge, as they require effective wound management to promote healing, reduce pain, and prevent complications. This study aimed to describe the use of a polylactic acid membrane in patients with burns of different depths and to assess wound healing outcomes. Methods: A descriptive case series was conducted including six patients with burn injuries treated with a polylactic acid (PLA) membrane (Suprathel®) at a specialized burn unit. The study was performed according to CARE guidelines. Clinical assessment included burn depth evaluation, pain measurement using the Visual Analog Scale, and scar assessment using the Vancouver Scar Scale. The application of the PLA membrane and its clinical performance during the healing process was described. Results: Complete wound closure was achieved in all cases by re-epithelialization as the PLA adhered, integrated and became transparent, clearly visualizing the progression of healing. Time to re-epithelialization ranged from 14 to 35 days, and final Vancouver Scar Scale scores ranged from 1 to 3 points. No major wound-related complications or local infections were documented during the clinical follow-up period. Conclusions: The use of a PLA membrane in burn management represents a promising advance in wound care, as it was associated with wound closure and pain reduction in this case series, with potential benefits for the optimization of nursing clinical practice.