Background: Climate change is increasingly recognized as a major global health threat, with disproportionate impacts on vulnerable populations, including women living with breast cancer who are receiving palliative care. These women often experience compounded physical, psychological, and socioeconomic burdens that may be intensified by climate-related stressors such as heatwaves, flooding, and disruptions to healthcare delivery. However, there is limited evidence from low- and middle-income countries, including Ghana, on how climate change affects the palliative care continuum and quality of life (QoL) among this population. Materials and Methods: A qualitative descriptive phenomenological design was employed to explore the experiences of women with breast cancer receiving palliative care at Ho Teaching Hospital, Ghana. Fourteen participants were purposively sampled between January and March 2026. Data were collected through semi-structured in-depth interviews conducted face-to-face. Interviews were audio-recorded, transcribed verbatim, and analyzed using Graneheim and Lundman’s conventional content analysis approach. Trustworthiness was ensured through credibility, dependability, confirmability, and transferability strategies. Ethical clearance was received before data collection began (HTH-REC/EX/2026/003) Results: Four main themes and thirteen sub-themes emerged: (1) Climate-related environmental disruptions (extreme heat, flooding, and unreliable electricity supply); (2) Health-related consequences along the palliative care continuum (symptom exacerbation, treatment interruptions, and reduced care accessibility); (3) Psychosocial and economic strain (emotional distress, financial hardship, food and water insecurity); and (4) Adaptive and coping responses (spiritual coping, family support, and reliance on healthcare providers and community networks). Conclusion: The study demonstrates that climate change significantly disrupts the palliative care continuum and diminishes the quality of life of women with breast cancer through interconnected environmental, clinical, and psychosocial pathways. Strengthening climate-resilient palliative care systems, improving healthcare infrastructure, and integrating psychosocial and environmental adaptation strategies into oncology and palliative care practice are urgently needed.