Advanced Driver Assistance Systems (ADAS) have demonstrated safety potential and are becoming increasingly available in the vehicle markets across the world. However, drivers’ perceptions, trust, and engagement with these systems in Thailand remain unexplored. This study therefore aimed to explore Thai drivers’ perceptions towards ADAS and investigated factors associated with trust and intention to use. A cross-sectional survey was conducted with 849 licensed drivers in Thailand. The online survey measured perceived usefulness, perceived ease of use, trust, barriers and concerns, expectations and preferences, and intention to use ADAS. Data were analyzed using Mann–Whitney U tests and Spearman’s rank correlations. Results showed that Thai drivers reported positive perceptions of usefulness and intention to use ADAS, while trust was moderate, and barriers and concerns showed variability. Trust demonstrated strong positive associations with perceived usefulness (ρ = .69), perceived ease of use (ρ = .56), and intention to use (ρ = .49). The findings highlight the important role of perceived usefulness, perceived ease of use, and trust in shaping drivers’ intent to use the system and supports the development of learning strategies to enhance ADAS usage whilst promoting utilization of these systems.