Optotransduction Pathway, Exploring Connections with Inflammation

The ability of cells to translate optical radiation into biochemical signals, i.e., optotransduction, plays an important role in emerging therapeutic strategies, with a relevant influence on inflammation. However, a systemic understanding of the molecular pathways underlying the transduction of these physical stimuli is still lacking. In this work, we present a molecular map of optotransduction reconstructed from the literature and provide its representation as pathway, using the standard Systems Biology Markup Language. This representation enables network-based analyses and allows us to investigate the differential effect of stimuli wavelengths and overlap with other forms of physical transduction, namely mechanotransduction.