Submitted:
27 April 2026
Posted:
28 April 2026
You are already at the latest version
Abstract
Keywords:
1. Introduction
2. Rare Genetic Traits in Plants
2.1. Sources of Rare Plant Genetic Traits
2.1.1. Role of Crop Wild Relatives in Sustaining Rare Genetic Traits
2.1.2. Role of Traditional Landraces and Indigenous Varieties in Sustaining Rare Genetic Traits
2.2. Role of Unique Plant Gene Classes in Environmental Stress Tolerance
2.2.1. Drought and Heat Stress
2.2.2. Salinity, Flooding, and Soil Degradation
2.2.3. Resistance to Pests and Diseases
3. Rare Genetic Traits in Animals
- Genetic Foundation of Exceptional Animal Traits
- b. Consequences of Animal Genetic Trait Loss and Species Extinction
- c. Contributions to Medicine and Technology
4. Strategies for Preserving/Conserving Rare Genetic Traits
4.1. Strategies for Plant Genetic Traits
4.2. Strategies for Rare Animal Genetic Traits
5. Why Immediate Action is Necessary
6. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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| S.no. | Source | Rare Animal Gene (s) | Natural purpose | Application | Use in Medicine and Technology | Status | Source |
|---|---|---|---|---|---|---|---|
| 1 | Rana sylvatica (Wood frog) | Glucose transporter and cryoprotectant genes | Allows frog tissues to survive freezing | Cryomedicine | Organ preservation and hypothermic surgery research | Experimental | [56] |
| 2 | Dipodomys deserti (Kangaroo rat) | ACTN3 variants (alpha-actinin-3 related) | Enables powerful hind-limb muscles for extreme jumping | Muscle physiology research | Treatments for muscular disorders and sports medicine | Early physiological research | [57] |
| 3 | Ornithorhynchus anatinus (Platypus) | Defensin-like venom peptide genes (OvDLPs) | Venom used by males during mating competition | Pain research | Development of novel analgesics | Early biomedical research | [58] |
| 4 | Leptonychotes weddellii (Weddell seal) | Myoglobin gene adaptations | Allows prolonged underwater diving | Hypoxia tolerance studies | Understanding oxygen deprivation in stroke and cardiac arrest | Experimental research | [59] |
| 5 | Chionodraco rastrospinosus (Antarctic icefish) | AFGP (Antifreeze Glycoprotein gene) | Prevents ice crystal formation in blood and tissues in sub-zero Antarctic waters. | Cryobiology and cryopreservation technology. | Organ preservation, fertility treatment (embryo freezing), cell storage. | Experimental to early applied biomedical research | [60] |
| 6 | Hypogastrura harveyi (Snow flea) | Ice-binding protein gene (IBP) | Prevents freezing of body fluids | Cryomedicine | Organ transplantation preservation | Experimental research | [60] |
| 7 | Odontodactylus scyllarus (Mantis shrimp) | Multiple opsin genes | Allows detection of polarized and ultraviolet light | Optical technology | Advanced imaging sensors and polarization cameras | Early technology research | [61] |
| 8 | Euprymna scolopes (Hawaiian bobtail squid) | Host-symbiosis regulation genes | Controls symbiosis with bioluminescent bacteria | Microbiome research | Synthetic biology and microbial engineering | Experimental research | [62] |
| 9 | Balaena mysticetus (Bowhead whale) | ERCC1 and PCNA pathway genes | Enhanced DNA repair and long lifespan | Aging research | Anti-aging and cancer-prevention research | Experimental | [63] |
| 10 | Heterocephalus glaber (Naked mole-rat) | HAS2 (Hyaluronan synthase 2) | Produces high-molecular-weight hyaluronan | Cancer biology | Anti-tumor therapies | Experimental research stage | [64] |
| 11 | Somniosus microcephalus (Greenland shark) | Collagen-stability genes | Maintain tissues for centuries of lifespan | Aging research | Anti-aging therapies and tissue repair | Early research | [65] |
| 12 | Anser indicus (Bar-headed Goose) | Hemoglobin alpha-chain mutation genes | Efficient oxygen binding at high altitude | Hypoxia research | Studying treatments for altitude sickness and respiratory diseases | Experimental biomedical research | [66] |
| 13 | Electrophorus electricus (Electric eel) | Voltage-gated ion channel genes (e.g., SCN4A) | Produce high-voltage electric discharges | Bio-battery design and bioelectronics | Energy-generating biological systems and neural interface research | Experimental research | [67] |
| 14 | Ramazzottius varieornatus (tardigrade) | Dsup (Damage suppressor protein) | Protects DNA from radiation and oxidative damage. | Radioprotection in cells. | Cancer radiation therapy protection, astronaut protection in space missions. | Experimental research stage | [68] |
| 15 | Ginglymostoma cirratum (Nurse shark) | VNAR antibody genes | Immune defense using small, stable antibodies. | Therapeutic antibodies and diagnostic tools. | Cancer therapy, targeted drug delivery, virus detection. | Clinical research stage | [69] |
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