Clinical Evaluation of Rocket Leaves Extract (Kyoh®) on Hair Density and Follicular Parameters in Subjects with Hair Loss

Background: Hair loss is a multifactorial condition influenced by aging, oxidative stress, hormonal regulation, and nutritional status. Nutraceutical supplementation has emerged as a potential strategy to support hair follicle function. This study evaluated the clinical efficacy of a nutraceutical ingredient (Kyoh®) at two concentrations versus placebo in individuals with hair loss. Methods: A randomized, parallel-group study was conducted in 150 volunteers aged 30–60 years. Participants received a high-dose (Kyoh BB-01), low-dose (Kyoh BB-02), or placebo (Kyoh BB-03) for 84 days. Hair parameters were assessed by digital trichoscopy at baseline, day 56, and day 84. Endpoints included hair density, follicular unit density, hair diameter, and hairs per follicular unit. Hair shedding was evaluated by comb test, and subjective perception by questionnaires. Results: The high-dose group showed significant increases in hair density and follicular unit density at days 56 and 84, as well as higher hairs per follicular unit at day 84. The low-dose group also improved these parameters to a lesser extent. No significant changes were observed in the placebo group. Hair diameter and shedding remained unchanged. Subjective results supported instrumental findings. Conclusion: The nutraceutical improved key hair growth parameters, with greater efficacy at higher dose.