Mitigating Ammonia-Triggered Inflammation in Human Skin Model: Modulatory Effects of a Purified Water Wipe Formulation

Irritant contact dermatitis is an inflammatory skin condition caused by exposure of the skin to substances or the environment that damages the skin barrier. Irritant contact dermatitis presents on the skin as a rash accompanied by redness, itching, burning sensation, blisters and cracking of the skin. In babies, it is more commonly known as diaper dermatitis or diaper rash but can also present in older children and adults with incontinence issues. General measures to prevent irritant contact dermatitis in babies includes frequent nappy changes to keep the baby’s skin as dry as possible, regular cleaning to remove urine and feces to maintain a healthy skin pH level and the use of products with minimal chemical irritants (wipes, diapers, barrier creams etc.). This study evaluates the effectiveness of a water-based wipe liquid (WaterWipes®) to reduce urine-induced inflammation in a 3D in vitro human skin model.