(Background/Objectives): This study aims to evaluate the efficacy of an ultrasound-guided infiltration method with hyaluronic acid and corticosteroids in the treatment of Temporomandibular Disorders (TMD). (Methods): Twenty-eight patients (16 females and 12 males), aged between 25 and 55 years, with TMD and evidence of retrodiscal tissue hyperemia on Magnetic Resonance Imaging (MRI) of the Temporomandibular Joint (TMJ) were enrolled. Before treatment, the intensity of preauricular pain was assessed using the Visual Analogue Scale (VAS), and the presence of associated symptoms such as tinnitus, vertigo, headache, and joint clicking was recorded. After the creation of individualized interocclusal devices, a bilateral ultrasound-guided infiltration of low molecular weight hyaluronic acid and corticosteroid was performed. (Results): Immediately after treatment, joint clicking disappeared in 80% of patients. Follow-up assessments at 30, 60, and 90 days, supported by control ultrasound, showed a substantial and statistically significant (p < 0.001) improvement in pain symptoms. (Conclusions): The ultrasound-guided infiltration technique proved to be a valid short-term therapeutic option for patients with TMD and inflammation of the retrodiscal tissue. A larger sample size and long-term follow-up are necessary to confirm these preliminary results.