Recent Advances in Wound Healing, Tissue Repair, Regeneration and Scar Management

Introduction: Wound healing, tissue repair, and regeneration are biological processes essential for restoring tissue integrity following injury. Disorders in these processes can lead to complications and the formation of scars, impacting both physical and psychological well-being. Methods: This review synthesizes recent advancements in understanding of the molecular and cellular mechanisms governing these processes. We explore the sequential phases of wound healing, the key cellular and molecular players involved, factors influencing healing outcomes, and emerging therapeutic strategies. Special emphasis is placed on novel biomaterials, cell-based therapies, gene therapies, and physical modalities. Modern therapeutic approaches aim to accelerate healing while minimizing complications such as scarring, infection, or chronic inflammation. Among the commercially available topical agents, Dermatix Ultra, Epicyn, Flosteron, and Contractubex are widely used and studied. Results: This review provides a contemporary analysis in the context of wound healing, tissue repair, and scar management, with an evidence-based comparison of these agents, focusing on their composition, mechanisms of action, clinical applications, and a comparative perspective on their efficacy in improving scar outcomes. Conclusion: Thus, this review aims to provide clinicians and patients with an up-to-date understanding of these treatments to facilitate informed decision-making in scar management. Finally, we discuss current challenges and future directions in the field, highlighting the potential for personalized medicine and translational research.