Background
Blindness and visual impairment represent significant global health challenges, disproportionately affecting low- and middle-income countries (LMICs) [
1]. According to the World Health Organization (WHO) and a recent review in
The Lancet Global Health, more than 2.2 billion people globally live with some form of vision impairment, and nearly half of these cases are preventable or remain unaddressed [
2].
An estimated 43 million people are blind, 295 million have moderate visual impairment (MVI), and 33.6 million suffer from severe visual impairment (SVI). Among those aged 50 and above, approximately 501 million have near vision impairment caused by uncorrected presbyopia [
1,
3].
To address the burden of visual impairment (VI), the WHO introduced the global eye health resolution (Resolution WHA74.12:
Integrated people-centered eye care, including preventable vision impairment and blindness), setting achievable global eye care targets for 2030 [
4]. These targets focus on effective Refractive Error Coverage (eREC) and effective cataract surgery coverage (eCSC) [
5,
6]. Effective Refractive Error Coverage (eREC) refers to the proportion of individuals with refractive error who receive corrective lenses or treatment that restores their visual acuity to a functional level, emphasizing quality and impact rather than quantity of services [
6,
7]. Meanwhile, Effective Cataract Surgery Coverage (eCSC) represents the proportion of individuals with cataract-related vision impairment who undergo surgery that successfully restores functional vision. This measure highlights the importance of combining access to surgical services with optimal outcomes.
Sub-Saharan Africa, including Uganda, bears a significant portion of the global burden of VI due to limited access to quality eye care [
8], inadequate healthcare infrastructure, and persistent socio-economic barriers [
9]. Globally, the leading causes of blindness include cataracts, refractive errors, glaucoma, diabetic retinopathy, and age-related macular degeneration (ARMD) [
10]. Cataracts alone account for approximately 51% of global blindness, but many regions, including Uganda, struggle to meet elimination targets set by initiatives such as WHO’s
VISION 2020: The Right to Sight [
11,
12] and the current 2030 Eye Health agenda [
4]. While these initiatives have achieved considerable progress globally, they remain underutilized in resource-constrained areas like Uganda, where access to care is still a major challenge.
The WHO recommends periodic population-based studies, such as the Rapid Assessment of Avoidable Blindness (RAAB) [
13,
14], to gather data essential for planning programs aimed at preventing avoidable blindness and VI. RAAB is a standardized methodology that provides reliable data specifically for individuals aged 50 and above, the age group with the highest prevalence of VI [
13]. This approach ensures targeted strategies and resource allocation to reduce preventable blindness effectively.
Blindness and visual impairment are closely intertwined with broader global health challenges, including disability, poverty, and reduced quality of life [
3,
15]. The WHO recognizes blindness as both a cause and a consequence of poverty, particularly in regions like Northern Uganda, where widespread poverty exacerbates the economic and social vulnerability of those with visual impairments. Blindness limits individuals’ ability to work or care for their families, compounding their financial instability. Additionally, people with visual impairments frequently experience social stigma and exclusion, further limiting their opportunities for education, employment, and social integration [
15].
The United Nations Convention on the Rights of Persons with Disabilities (UNCRPD) defines people with disabilities as those with “long-term physical, mental, intellectual, or sensory impairments, which in interaction with various barriers may hinder their full and effective participation in society on an equal basis.” [
16,
17,
18] Disabilities, including those caused by reduced vision, are closely linked to socio-economic disparities, further marginalizing affected individuals. Evidence suggests that people with disabilities are less likely to access essential health services, underscoring the need to understand their specific barriers to eye care [
19]. By strengthening eye care services and integrating them into broader health systems, the burden of disabilities related to visual impairment can be significantly alleviated, ensuring more equitable access and improved outcomes for all [
20,
21].
Measuring disability among individuals aged 50 and above in RAAB studies is an essential step toward understanding the complex interplay between aging, disability, and visual impairment [
13]. As people age, they face an elevated risk of both functional disabilities and vision loss, conditions that frequently coexist and amplify the difficulties encountered in daily life and access to healthcare. Disability often intersects with other social determinants such as gender, poverty, and geographic location, creating additional layers of inequity [
19,
22]. By collecting data on functional difficulties in this age group, researchers can gain valuable insights into the specific barriers that hinder access to eye health services, such as physical mobility issues, limited social support, or stigma associated with disability. This data allows for the identification of vulnerable populations, such as women, rural dwellers, or individuals living in extreme poverty, who are disproportionately affected by these challenges [
23].
Furthermore, understanding the extent and types of disabilities in this demographic enables the development of tailored, inclusive eye health programs that address these unique needs [
24,
25]. Inclusive strategies might involve improving community-based outreach, offering accessible transport to health facilities, or integrating disability-friendly services within primary eye care. Without systematically capturing data on disability, significant disparities in health outcomes and access to services are likely to persist, particularly in low-resource settings where health systems already face considerable strain. Addressing these gaps not only ensures more equitable service delivery but also aligns with global commitments to leave no one behind in efforts to reduce avoidable blindness and improve overall health equity [
25,
26].
Uganda, in Eastern Africa, with a population of approximately 46 million people, is highly underserved in terms of eye care, with just 1 ophthalmologist serving every 1 million people [
8]. This critical shortage disproportionately affects individuals with disabilities, particularly those in rural areas, who often face compounded barriers such as limited mobility, stigma, and a lack of disability-inclusive health services. These challenges significantly exacerbate inequities in accessing timely and effective eye care, leaving many preventable cases of blindness and visual impairment unaddressed.
Northern Uganda, a region that has endured decades of conflict and socio-economic instability, is particularly vulnerable to blindness and visual impairment [
8]. Poverty and displacement caused by past conflicts have left a legacy of underdevelopment, severely straining healthcare systems, including eye care services. The critical shortage of trained ophthalmologists, optometrists, and support staff in the region continues to hinder timely interventions for those in need. For many, sporadic and inadequately resourced outreach programs remain the only feasible access point for care. Moreover, comprehensive data on the prevalence of disabilities in the region is scarce, posing challenges to designing inclusive healthcare programs.
Although data on the prevalence and causes of blindness and visual impairment have been collected over the past decade, including from the last RAAB conducted in 2015 [
27] across five districts in Northern Uganda, which estimated blindness prevalence at 6.0% (5.2–6.8), no information on general disability was captured. This omission highlights the growing need to integrate disability measurement within RAAB studies to generate data that can guide the planning of inclusive services addressing both visual impairment and broader disabilities.
The recent RAAB in Northern Uganda provided an opportunity not only to update data on eye health status and service coverage since the 2015 study but also to collect critical disability-related data. This addition was vital to ensure that future community programs are inclusive and cater to the needs of all people in the region, including those with disabilities, who often face the greatest barriers to care.
This study aimed to estimate the prevalence and causes of blindness and visual impairment, determine the prevalence of disability, and explore the relationship between disability and eye health among people aged 50 years and above in Northern Uganda.
Methods
Study Design and Location
This was a descriptive cross-sectional population-based study conducted in five districts in the Northern Province of Uganda (Pader, Agago, Kitgum, Lamwo, and Amuru), covering a total population of 1,066,000, between November and December 2023.
Study Population
The study population included individuals aged 50 years and above who resided in the aforementioned districts, had consented to participate, and had been ordinarily resident in their households for at least six months.
Sample Size
The sample size was calculated using the RAAB (version 7) [
13] software package. Key inputs included total population, a prevalence estimate of blindness at 4.0% ± 20% with 95% confidence, a non-response rate of 10%, and a design effect of 1.5. This yielded a required sample size of 3,800 participants, obtained through 76 clusters of 50 adults aged 50 and above.
Sampling Method
A two-stage sampling method was employed. In the first stage, 76 primary sampling units (villages) were selected using probability proportionate to size methodology, based on population data from the Uganda Bureau of Statistics (UBOS). Villages were listed in the RAAB7 software [
13], which facilitated random selection.
Within each village, 50 eligible participants were enrolled. A cluster informer visited the village a few days before the study team arrived and worked with local leaders to identify village boundaries. In villages with populations exceeding 500 inhabitants, the area was divided into smaller segments, and one segment was randomly selected. On the study day, the team began at the house nearest the main road and enumerated all eligible respondents, including those temporarily absent, revisiting households as needed. Basic data about absent participants was collected from family members or neighbors when possible.
Data Collection
Participants underwent initial visual examinations, followed by disability assessments using the open-access RAAB7 questionnaire [
28]. Data was collected using an app on touchscreen smartphones, with village-level GPS coordinates recorded to facilitate geospatial analysis. Written consent was obtained from all participants, and illiterate participants provided a thumbprint, which was witnessed by an independent person.
Data was synced daily to a cloud server accessible only to the study team responsible for management and analysis. The RAAB7 app included built-in checks to minimize errors, and data quality was regularly reviewed by team members, with feedback provided to address inconsistencies.
Visual Examination
Each participant underwent a standardized ophthalmic assessment by trained team members, including:
Presenting visual acuity measurement using the RAAB smartphone application, with pinhole testing for eyes presenting <6/12.
Lens examination with a torch in a darkened room for all participants.
Determination of the primary cause of visual impairment for each eye presenting <6/12.
Questions regarding cataract surgery and, where applicable, reasons for non-surgery.
Minor ocular conditions were treated on-site, and participants needing further care were referred. Posterior-segment examination was performed using a direct ophthalmoscope for eyes with presenting visual acuity <6/12 when the cause was not attributable to refractive error, cataract, or corneal opacity, in line with the RAAB7 protocol. Participants with normal vision (≥6/12) were not routinely examined for posterior-segment changes, as the survey aimed to identify causes of existing visual impairment and blindness rather than subclinical disease.
Training
A certified RAAB trainer (KK) conducted a four-day training session, following the standard RAAB7 protocol. The training covered procedures for visual and disability assessments, with Days 1 and 2 focused on methodology and procedures, Day 3 on inter-observer variability (IOV) testing, and Day 4 on field practice. Teams were provided standardized instructions and reference materials, and retraining was conducted as needed until at least 60% agreement in IOV assessments was achieved.
Study Logistics
Five standardized teams collected data, each comprising an ophthalmologist as the team leader, an assistant (cataract surgeon or ophthalmic clinical officer), a cluster informer, a driver, and a village guide.
Data Management and Analysis
RAAB7 provided built-in analysis and prompts. Initial data cleaning was conducted by the trainer, with support from the International Centre for Eye Health (ICEH). Results were automatically generated within the RAAB7 software.
Ethical Considerations
The study was approved by two Internal Review Boards (IRBs): the Mulago Ethics Research Committee, and the Uganda National Council for Science and Technology. Written consent was obtained from all participants.
Results
Study sample and demographic characteristics
A total of 137, 532 persons aged 50 and above were in the area, among which 3972 participants were eligible, and 3662 (97.3%) were examined.
Table 1 shows Age and Sex distribution of those examined.
The demographic characteristics of the participants show a balanced gender distribution, with 51% female and 49% male respondents. The age–sex distribution of participants closely reflected the census population structure for adults aged ≥ 50 years in northern Uganda, though with a slight over-representation of women and the oldest age group (≥ 70 years), a pattern typical of household-based surveys in which older and more home-based individuals are more likely to be available for examination.
The mean age of participants was 63.5± 8.4 years, consistent with the age distribution expected among adults ≥ 50 years in the RAAB sampling frame, with almost half of the population aged 50 and above falling within the 50-59 age group. Women tend to be slightly more with increased age.
Table 2 shows the adjusted prevalence and extrapolated magnitude of blindness, severe, moderate and mild vision impairment.
The adjusted prevalence of blindness was 2.5% (95% CI 1.7–3.4), while severe and moderate visual impairment accounted for most of the burden. For visual impairment, 3.2% had severe visual impairment (SVI), and 9.3% had moderate visual impairment (MVI). Spectacle coverage was very low, with REC at 1.0% and eREC at 0.6%, far below WHO 2030 targets.
Table 3 examines the principal causes of blindness and visual impairment. Untreated cataracts accounted for 51.3% of blindness, followed by glaucoma (13%) and posterior segment disease (7.8%). For moderate and mild visual impairment, uncorrected refractive error was the most common cause, comprising 22% and 64.4% of cases, respectively.
Table 4 shows the crude prevalence of self-reported disability by functional domain, using the Washington Group Questions (WGQs).
In all domains (except for communication), there were more women than men. The most common reported form of disability was seeing (11.5%), seconded by mobility (5.1%). Women reported higher rates of disability across most domains compared to men.
Figure 1 shows prevalence of disability plotted against age
Disability prevalence commonly increases with age on account of many age-related conditions that can affect functioning (e.g., cataract, ARMD, arthritis, dementia).
Table 5 shows the adjusted prevalence of vision impairment by disability status
Blindness and visual impairment are highly associated with disabilities. Among participants with any disability, 24.7% were blind, compared to only 0.9% of those without disabilities. Similarly, severe and moderate visual impairment were significantly more prevalent among individuals with disabilities.
People without any other disability are less likely to be blind, or have severe, moderate or mild VI compared to those who are disabled.
Table 6 shows the adjusted effective cataract surgical coverage by disability status
Effective Cataract Surgical coverage (eCSC) was much higher in individuals without disabilities across all cataract thresholds, ranging from 6.9% for blindness to 25.8% for mild visual impairment. In contrast, participants with disabilities had significantly lower eCSC rates, indicating inequities in surgical access and outcomes.
Discussion
This study examined self-reported disability and its relationship with findings from the RAAB conducted in Northern Uganda. Using the RAAB methodology, the study integrated the Washington Group disability (WGS) [
30] tool to assess self-perceived functional limitations across seven domains (seeing, hearing, mobility, communication, cognition, anxiety, and depression). We explored the relationship between disability and visual impairment, identified gaps in service provision, and provided recommendations for inclusive eye health programs.
The findings reveal significant insights into the link between disability and visual impairment. Women were slightly more represented in older age groups (
Table 1). This higher representation highlights the need for gender-sensitive eye health and disability planning, proportionally targeting more women than men. Gender differences in blindness are well known, with more women affected than men [
31,
32,
33,
34].
Unoperated cataract remains the leading cause of blindness, accounting for 51.3% of cases (
Table 3), consistent with trends observed in RAAB surveys across LMICs [
3,
35]. Cataract is treatable, and high proportions of untreated cases indicate weaknesses in the eye health system, resulting in low coverage of necessary services. Considering that among those who are blind or have severe visual impairment (
Table 2), half have unoperated cataracts requiring surgery, the estimated number of unoperated cataracts in the surveyed province alone exceeds 3,900 cases.
The WHO launched SPECS 2030 [
6], a global initiative to improve access to refractive error services, endorsed at the World Health Assembly in 2021. The strategy focuses on five key areas: improving Services, building Personnel capacity, enhancing Education, reducing Costs, and strengthening Surveillance. Despite this, the current RAAB survey found limited access to refractive error services, with uncorrected refractive error contributing to 22% of moderate and 64.4% of mild visual impairment cases. These findings indicate minimal progress in improving access to corrective eyewear.
The low effective coverage for refractive error highlights limited access to affordable vision correction in rural northern Uganda. Levels far below WHO 2030 targets reflect structural inequities, with vision-related disability concentrated among older adults and women. Strengthening primary eye care and community-based optical services is essential to advance universal eye health coverage and address broader health-system gaps in access and equity.
Additionally, two neglected tropical diseases (NTDs) targeted for elimination by 2030 [
36]—trachoma and onchocerciasis—remain prevalent. Both require annual community-based mass drug administration with azithromycin and ivermectin, respectively. Posterior segment diseases, including glaucoma (13%), other retinal diseases (7.8%), and age-related macular degeneration (9.1%), collectively accounted for 29.1% of visual impairment. These conditions are particularly concerning as they are complex to treat, and minimal interventions exist in resource-limited settings.
The study also highlights the increasing prevalence of disability with age (
Figure 1), which results from physiological decline, cumulative disease risk, and social factors. Age-related changes, including reduced muscle strength, chronic conditions like arthritis, sensory impairments, and neurodegenerative diseases, contribute significantly to functional limitations. Falls, fractures, and comorbidities further exacerbate disability risks, while limited healthcare access, poverty, and gender disparities compound these challenges, particularly in low-resource settings. Social and environmental barriers, cognitive decline, and mental health issues such as depression also play a role. Addressing these challenges requires age-friendly health systems, community-based interventions, and disability-inclusive policies.
The crude prevalence of self-reported disability by domain (
Table 4) found “seeing” to be the most commonly reported disability (11.5%). This aligns with similar studies using the WGS tool, such as a recent study in western Uganda, which found a similar high prevalence [
37]. The high prevalence is linked to the burden of age-related eye conditions such as cataracts, glaucoma, and uncorrected refractive errors, particularly in resource-limited settings. Since vision impairment directly affects daily activities, individuals are more likely to report it. Limited access to cataract surgery and glasses exacerbates the issue, while coexisting disabilities further impact quality of life.
There is a strong association between disability and visual impairment (
Table 5). Persons with non-seeing disabilities are more likely to be blind or visually impaired due to shared risk factors, healthcare barriers, and increased vulnerability to injuries. Chronic conditions such as diabetes, stroke, and neurological disorders often contribute to both physical and visual impairments [
19]. Limited mobility and reliance on caregivers can delay eye care access, worsening preventable vision loss [
16,
19]. Additionally, these individuals face higher risks of falls and trauma-induced eye injuries, further complicating their vision challenges. Cognitive impairments may contribute to undiagnosed vision problems, as affected individuals struggle to recognize or communicate their difficulties [
19]. Socioeconomic factors, including poverty, gender, and stigma, further restrict access to care and rehabilitation services [
17,
31,
32,
33]. The strong association between disability and visual impairment underscores the need for integrated, disability-inclusive healthcare services that address both medical and structural determinants of inequity [
20,
24,
25].
Disparities in Effective Cataract Surgical Coverage (eCSC) by disability status reveal significantly lower rates among individuals with disabilities (
Table 6). This is likely due to multiple barriers, including mobility restrictions, inaccessible healthcare facilities, and financial constraints [
16,
17,
19]. Socioeconomic disadvantages, such as poverty and unemployment, further reduce the ability to afford surgery [
31,
32,
33]. Stigma and discrimination contribute to marginalization, while low awareness and misperceptions about cataract surgery delay care-seeking [
17,
32]. Additionally, coexisting health conditions may increase surgical risks, making providers hesitant to operate [
19]. Without disability-inclusive healthcare policies, individuals with disabilities experience inequitable access to cataract surgery, leading to poorer visual outcomes and quality of life [
20,
24,
25].
The findings highlight critical equity issues within the global eye health landscape. People with disabilities face significant disparities in accessing eye care services [
38,
39,
40], reflecting broader systemic inequities. The lower rates of cataract surgical coverage and refractive error correction among participants with disabilities underscore the intersection of disability, poverty, and healthcare access. Globally, disability is both a cause and consequence of inequity, particularly in low-resource settings where social determinants such as income, education, and geography exacerbate healthcare barriers. In Northern Uganda, these disparities are compounded by a history of conflict and underdevelopment, leaving healthcare systems strained and inaccessible to many.
Recommendations
To address these disparities, integrating disability-inclusive strategies into national eye health programs is essential. Healthcare providers should receive training to accommodate the needs of individuals with disabilities, and eye care facilities must be made physically accessible. Outreach programs should target underserved populations, addressing barriers such as cost and transportation.
Efforts should also focus on improving cataract surgical coverage and refractive error correction among persons with disabilities through subsidized surgical programs and affordable corrective lenses. Community-based rehabilitation can support individuals with disabilities in accessing follow-up care and assistive devices.
Additionally, data collection should be expanded to include disability as a core component of RAAB surveys, ensuring accurate monitoring of progress and the development of evidence-based interventions. Collaboration with disability advocacy groups and local communities is crucial to ensure culturally sensitive and effective eye health programs. These measures will help establish an equitable eye care system that benefits all individuals.
Study Limitations
This study has several limitations. First, reliance on self-reported disability data may introduce bias, as perceptions of difficulty vary among individuals. Because participants underwent detailed eye examinations and were sensitized to vision-related questions, they may have been more likely to report vision problems than other functional limitations. This pattern likely reflects both the true burden of visual impairment and a degree of reporting bias arising from the survey’s vision-focused context. Second, the cross-sectional design precludes causal conclusions about the relationship between disability and visual impairment. Third, the study focused exclusively on individuals aged 50 years and above, excluding younger populations who may also experience significant disabilities and vision problems. Finally, logistical challenges in reaching remote areas may have affected sample representativeness. Despite these limitations, the study offers valuable insights into disability and visual health in Northern Uganda.