Enterprise Customer Relationship Management (CRM) platforms have evolved from simple contact databases into complex, multi-tenant cloud ecosystems that serve as the operational backbone for Fortune 500 organizations. Despite this criticality, no unified reference framework exists that catalogues the architecture and design patterns specifically adapted for constrained multi-tenant CRM environments, nor examines how the rapid integration of artificial intelligence is reshaping these architectural foundations. This paper presents a practitioner-driven reference framework comprising 14 architecture and design patterns organized across four layers — Data Architecture, Business Logic, Integration, and Presentation — derived from longitudinal analysis of enterprise CRM implementations spanning 17 years across financial services, telecommunications, healthcare, energy, and consumer goods sectors. We identify three categories of patterns: (1) Governor-Aware Patterns that optimize resource consumption within platform-enforced execution limits; (2) Multi-Tenant Isolation Patterns that ensure data and process separation in shared infrastructure; and (3) Platform Evolution Patterns that enable applications to adapt to platform releases without regression. Beyond the foundational pattern catalogue, we analyze the AI transformation reshaping CRM architecture across three generations — predictive, generative, and agentic AI — documenting how these capabilities introduce new architectural layers (vector databases, knowledge graphs, AI agent orchestration), governance frameworks (Trust Layer, NIST AI RMF), and integration protocols (MCP, A2A). We further examine the provocative question of whether AI coding agents could enable enterprises to bypass CRM platforms entirely by building custom applications, presenting evidence-based analysis of AI developer productivity (including studies showing experienced developers are 19% slower with AI tools on complex codebases), code quality concerns (45% security vulnerability rate in AI-generated code), and seven structural platform advantages that historical precedent confirms have withstood four prior waves of "build your own" disruption. The CRM market continues to accelerate ($128 billion, 13.4% growth) with AI-in-CRM emerging as the fastest-growing subsegment at 28% CAGR, suggesting that AI will transform rather than displace enterprise CRM platforms.