This review examines the potential impact of potato biofortification on boosting climate resilience and enhancing the nutritional content of potato tubers to combat hidden hunger. It also explores future possibilities for biofortified potatoes as a food source during space travel or colonization. Widespread mineral deficiencies are prevalent globally, particularly in developing countries. Additionally, climate change could adversely affect potato production and soil nutrient absorption. In this context, developing breeding methods to develop cultivars that respond better to biofortification amid climate change is essential. These cultivars may be physiologically efficient at absorbing and transporting minerals into tubers. The review covers various approaches, including identifying germplasm accessions with enhanced micronutrient storage, understanding mechanisms of micronutrient uptake and translocation, and pinpointing genes related to micronutrient, oligopeptide transport, and lignads. It also discusses in vitro selection and screening of calli with improved capacity for micronutrient absorption and transport.