Dyslipidemia is a prevalent metabolic disorder and a major cardiovascular risk factor, often influenced by sedentary lifestyles and family history. This study analyzed the association between sedentary behavior, adiposity indicators, and family history with dyslipidemia in young adults from Trujillo in 2025. A cross-sectional correlational design was applied to 137 participants (41 men and 96 women). Sedentary behavior was measured using the IPAQ questionnaire, while family history of dyslipidemia or cardiovascular disease was recorded. Anthropometric indicators included waist circumference (WC), body mass index (BMI), relative fat mass (RFM), body roundness index (BRI), and conicity index (CI). Lipid profiles were assessed with Mission monitoring equipment. HDL-c was low (38.90 ± 16.45 mg/dL in men; 47.42±15.82 mg/dL in women), while LDL-c was slightly elevated (103.39 ± 36.36 mg/dL and 102.74±33.60 mg/dL). Average cholesterol and triglyceride concentrations were normal in both genders. WC, RFM, and BRI correlated with LDL-c, with RFM showing the strongest association (OR = 4.108; 95% CI: 1.266–13.332). Triglycerides were linked to BMI, WC, BRI, and sedentary lifestyle, with WC being most significant (OR = 6.125; 95% CI: 2.007–18.690). In conclusion, RFM and WC emerged as the most robust predictors of dyslipidemia, underscoring their utility for early detection of elevated LDL-c and hypertriglyceridemia in young populations.