The Synaptic Pruning Cliff: Threshold-Like Network Fragility Under Internal Stress and Efficient Recovery in a Computational Model of Depression

Background: Major depressive disorder (MDD) is increasingly viewed through a neuroplasticity lens, with developmental synaptic pruning emerging as a potential core liability. Genetic evidence implicates pruning pathways, while rapid-acting antidepressants like ketamine promote synaptogenesis, suggesting that excessive early elimination leaves circuits vulnerable to later stress. Few computational models, however, capture the specific MDD pattern of latent fragility collapsing under perturbation, followed by recovery via limited plasticity enhancement.Methods: An overparameterized feed-forward neural network (∼396,000 parameters) was trained on a noisy four-class Gaussian cluster task to represent dense early connectivity. Excessive pruning (95% magnitude-based weight removal, per-layer) simulated adolescent over-elimination. Fragility was assessed under input perturbations and internal neural noise (post-activation Gaussian injections at varying intensities) modeling neuromodulatory disruption. Recovery involved gradient-guided regrowth (50% of pruned connections, prioritized by loss-reduction potential) followed by fine-tuning. Comparisons included random regrowth and a sparsity sweep to identify thresholds.Results: The intact network showed robust performance across conditions. Pruning induced sharp collapse (clean accuracy ∼51%, standard noisy ∼43%), with pronounced sensitivity to internal noise (moderate stress accuracy ∼31%) exceeding input noise effects. Gradient-guided regrowth plus fine-tuning restored near-baseline accuracy (clean/standard ∼100%) and robustness (combined stress ∼97%) despite ∼47% persistent sparsity. Targeted regrowth slightly outperformed random under high stress. A critical threshold emerged around 93% sparsity, beyond which combined-stress performance dropped abruptly (>44 percentage points).Conclusions: Excessive pruning generates threshold-like intrinsic fragility consistent with stress-triggered MDD relapse, while targeted, limited synaptogenesis efficiently compensates without full density restoration. These findings support a pruning-mediated plasticity deficit as a mechanistic framework for MDD vulnerability and highlight the therapeutic potential of activity-dependent plasticity enhancement. The model provides a testable scaffold for linking polygenic pruning risk to circuit-level decompensation and rapid treatment response.