Submitted:
19 November 2025
Posted:
20 November 2025
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Abstract
Background: Immunisation is a protective measure against infectious diseases and is one of the most crucial public health interventions (WHO, 2019). Mothers face challenges which are facility-related factors such as long waiting times, stock-outs and negative staff attitudes, as well as cultural and religious beliefs held by mothers and families, which further shape whether children receive vaccinations (Wiysonge et al, 2020; South Africa qualitative study, 2023). Purpose: The aim of the study was to assess the experiences of mothers in accessing childhood immunisation services from the perspective of mothers in the paediatric outpatient department at a tertiary hospital in South Africa. Methodology: A quantitative cross-sectional design approach was used to investigate the challenges faced by mothers when accessing childhood vaccination. A probability sampling method was used to sample 221 respondents by means of systemic sampling. Data was collected by means of self-administered questionnaire. Validity was ensured through face and content validity. The reliability was ensured through clear and detailed instructions as well as pilot testing. Data was collected and analyzed using Statistical Package for Social Science (SPSS) version 27. The results analyzed were then carefully interpreted to identify key trends and patterns. The data analyzed was presented visually through tables and charts to make the findings easier to understand and interpret. Results: The study comprised of 222 participants. The study results showed that majority of mothers knew and understood enough about immunization and their advantages. However, long waiting times, high transport expenses and vaccine shortages made it difficult for many of the mothers and impacted schedule adherence. According to the study’s findings, expanding vaccine coverage requires improving service accessibility, effectiveness and ongoing health education. Conclusion: The study revealed that mothers face several challenges when accessing childhood immunisation services, including long waiting times, lack of information regarding vaccines and limited accessibility. These barriers negatively impact immunisation uptake and threaten child health outcomes. Recommendations: Addressing the challenges that mothers face when accessing immunisation through improved health education, resource allocation, and community engagement is essential to strengthen immunisation coverage.
Keywords:
1. Introduction
1.1. Background of the Study
1.2. Purpose of the Study
1.3. Objectives of the Study
- To describe the impact of socio-economic and primary healthcare facilities-related factors on mothers’ access to childhood vaccination services.
- To assess mothers’ experiences with accessing childhood immunisation services.
2. Methodology
2.1. Study Approach
2.2. Study Design
2.3. Study Site
2.4. Study Population
3. Sampling
3.1. Criteria for Inclusion
- Mothers of children under the age of 12 years who are currently receiving childhood immunisation.
- Mothers of children above the age of 12 years who have undergone childhood immunisation.
- Mothers who are 18 years older, as they were able to give consent.
3.2. Sampling Size
- Inclusion Criteria
- Mothers of children under the age of 12 years who are currently receiving childhood immunisation.
- Mothers of children above the age of 12 years who have undergone childhood immunisation.
- Mothers who are 18 years older and were able to give consent.
- Exclusion criteria
- Mothers with children who have never received childhood immunisation.
- Mothers younger than 18 years of age (cannot give consent).
- Mothers who are not willing to sign a consent form.
3.3. Sampling Technique
4. Data Collection Instrument
5. Validity and Reliability of Measuring Instrument
6. Pilot Study
7. Procedure for Data Collection
8. Management of Data and Analysis of Data
9. Ethical Consideration
10. Results
| Demographic Characteristics | Frequency | Percentages |
|---|---|---|
| Gender | ||
| Male | 0 | 0% |
| Female | 222 | 100% |
| Age | ||
| 18-25 | 33 | 14.9% |
| 26-35 | 117 | 52.7% |
| 36 and above | 72 | 32.4% |
| Marital status | ||
| Single | 178 | 80.2% |
| Married | 41 | 18.5% |
| Divorced | 1 | 0.5% |
| Widowed | 1 | 0.5% |
| Educational level | ||
| No formal education | 5 | 2.3% |
| Primary | 12 | 5.4% |
| Secondary | 124 | 55.9% |
| Tertiary | 81 | 36.5% |
| Employment status | ||
| Employed | 61 | 27.5% |
| Unemployed | 143 | 64.4% |
| Student | 11 | 5% |
| Informal worker | 7 | 3.2% |
| Household income | ||
| Less than R6888 | 161 | 72.5% |
| Between R6890 – R48752 | 40 | 18% |
| Above R48753 | 7 | 3.2% |
| Number of children | ||
| 0-1 | 73 | 32.9% |
| 2-4 | 127 | 57.2% |
| 5-7 | 8 | 3.6% |
| 8-11 | 1 | 0.5% |
| Age of youngest child | ||
| 0-1 | 69 | 31.1% |
| 2-4 | 62 | 27.9% |
| 5-7 | 42 | 18.9% |
| 8-11 | 33 | 14.9% |
| More than 12 | 16 | 7.2% |
| Percentage | ||
|---|---|---|
| Yes | No | |
| Have you heard of childhood immunisation before? | 90.1 | 9.0 |
| Do you know the recommended immunisation schedule? | 82.9% | 15.8% |
| Have you received a booklet for your child? | 83.8% | 14.9% |
| Have you ever missed a scheduled immunisation for your child? | 22.1% | 77% |
| Have you ever been turned away because vaccines were unavailable? | 23% | 76.6% |
| Healthcare workers provide enough encouragement and education about childhood immunisation? | 69.4% | 30.6% |
| Do you feel the clinics enough support to help you access immunisation services? | 77.5% | 22.1% |
| Did you receive the date for the next visit? | 93.7% | 6.3% |
| Did you receive education about potential adverse reactions after vaccination? | 58.1% | 41.9% |
| Were you informed about the next visit by the healthcare worker? | 90.5% | 9.5% |
| Do the clinic’s operating hours fit your schedule for taking your child for immunisation? | 81.5% | 18.5% |








11. Discussion of Results
11.1. Sociodemographic Context
11.2. Awareness and Knowledge
11.3. Access and System Barriers
11.4. Service Delivery Experience
11.5. Policy and Programme Implications
11.6. Recommendations:
- Strengthen service efficiency: Reduce waiting times by introducing dedicated immunisation days, appointment systems, and improved patient flow management.
- Enhance communication and counselling: Standardise information delivery using simple language and pictorial materials to accommodate caregivers of varying literacy levels.
- Address logistical and resource constraints: Ensure reliable vaccine supply through strengthened inventory management and timely replenishment to prevent stock-outs and service disruptions.
- Expand outreach and community engagement: Mobilise community health workers to provide follow-up support and home-based reminders for missed immunisations, especially for working and low-income mothers.
- Improve staff–patient interaction: Conduct periodic training on interpersonal communication, empathy, and cultural sensitivity to improve caregiver satisfaction and trust.
- Integrate monitoring and evaluation systems: Use digital tracking and routine supervision to identify children who miss doses and follow up promptly, supporting EPI-SA’s data-driven performance improvement model.
12. Conclusions
Acknowledgments
- We would like to express our deepest gratitude to all those who contributed to the completion of this research project.
- First and foremost, we are sincerely thankful to our supervisors, [Ms Mushasha and Ms Shabangu], for their invaluable guidance, constructive feedback, and continuous support throughout the study.
- We extend our appreciation to the Sefako Makgatho Health Sciences University Department of Pharmacy for providing the resources and opportunity to conduct this research.
- Special thanks to Dr George Mukhari Academic Hospital Out Paediatric Department for granting us the premises and their warm welcome during the research process, and all the participants who willingly took part in this study and shared their experiences.
Abbreviations
- EPI-SA - Expanded Programme Immunisation – South Africa
- HIC - High-Income Countries
- LMIC - Low and Middle-Income Countries
- OPD- Outpatient Department
- UNICEF - United Nations International Children’s Emergency Fund
- VPDs- Vaccine-Preventable Diseases
- WHO – World Health Organization
- SMUREC – Sefako Makgatho University Research Ethics Committee
Appendices
Appendix 1: TIME SCHEDULE
| ACTIVITY | JAN-FEB | MAR-MAY | JUN-AUG | SEP-OCT |
|---|---|---|---|---|
| Protocol compilation | X | |||
| Protocol submission | X | |||
| Pilot study | X | |||
| Data collection and analysis | X | |||
| Report compilation | X | |||
| Oral presentation and report submission | X |
Appendix 2: BUDGET
| BUDGET | COST |
|---|---|
| Printing of consent forms and questionnaires | R400 |
| Logistics | R400 |
| Statistician | R2500 |
| Total cost | R3300 |
Appendix 3: ENGLISH QUESTIONNAIRE

- CODE
- Do not write a name in the paper.
- Please answer all the questions with pen.
- Fill in the provided space.
- Circle the letters (e.g. A)
- Circle one or more answers provided, if applicable.
| SECTION A: DEMOGRAPHIC DATA | |
| QUESTIONS | ANSWERS |
| 1. Age of the mother | a. 18-25 Years b. 26-35 Years c. 36 and above |
| 2. Marital status | a. Single b. Married c. Divorced d. Widowed |
| 3. Education level | a. No formal education b. Primary c. Secondary d. Tertiary |
| 4. Employment status | a. Employed b. Unemployed c. Student d. Informal worker |
| 5. Household income | a. Low-income ( less than R6888.00 per month) b. Middle-income (R6890.00 to R48752.00 per month) c. High-income (R48753.00 and above per month) |
| 6. Number of children | ___ |
| 7. Age of youngest child | ___ months -----years |
| SECTION B: KNOWLEDGE AND AWARENESS OF IMMUNISATION | |
| 8. Have you heard of childhood immunisation before? |
a. Yes b. No |
| 9. Where do you get immunisation information? | a. Clinic b. Hospital c. Media d. Community Health Worker e. Family f. Other---------specify |
| 10. Do you know the recommended immunisation schedule for your child? | a. Yes b. No |
| 11. Do you believe immunisation prevents serious illnesses? | a. Yes b. No |
| 12. Name one disease prevented by vaccine/childhood immunisation | |
| 13. Have you received a vaccination booklet for your child? | a. Yes b. No |
| SECTION C: BARRIERS TO IMMUNISATION ACCESS | |
| 14. What challenges do you face when taking your child for immunisation? (Tick all that apply) a. Distance to the clinic is too far b. High transport costs c. Long waiting times at the clinic d. Unfriendly staff or healthcare workers e. Lack of information on when and where to go f. Vaccine shortages at the clinic g. Fear of side effects from vaccines h. Religious or cultural beliefs against vaccines i. Other (specify) ___ j. None |
|
| 15. Have you ever missed a scheduled immunisation for your child? | a. Yes b. No |
| 16. If the above answer is yes, what was the main reason for missing the vaccination? |
___ |
| 17. Financial constraints (e.g., transport costs,) have prevented me from accessing vaccination services. | a. Yes b. No c. Not applicable |
| SECTION D: PRIMARY HEALTHCARE FACILITY FACTORS, EXPERIENCE | |
| 18. How long do you typically wait at the clinic for immunisation services? | a. Less than 30 minutes b. 30 minutes – 1 hour c. More than 1 hour d. More than 3 hours |
| 19. How would you rate the attitude of healthcare workers? | a. Very friendly b. Neutral c. Unfriendly |
| 20. Have you ever been turned away because vaccines were unavailable? | a. Yes b. No |
| 21. Healthcare workers provide enough encouragement and education about childhood vaccination. | a. Yes b. No |
| 22. Do you feel the clinics provide enough support to help you access immunisation services? | a. Yes b. No |
| 23. Did you receive the date for the next visit? | a. Yes b. No |
| 24. Did you receive education about potential adverse reactions after vaccination? | a. Yes b. no |
| 25. Were you informed about the next visit by the healthcare worker? | a. Yes b. No |
| 26. Do the clinic’s operating hours fit your schedule for taking your child for immunization? | a. Yes b. No |
Appendix 4: SETWANA QUESTIONNAIRE

- KHOUTU
- Ditaelo
- Tsweetswee araba dipotso tsotlhe o dirisa pene.
- Tlatsa sebaka se se neetsweng.
- Tshwaya kgotsa kgabaganya mo sebakeng se se neetsweng.
- Tlhopha karabo e le nngwe kgotsa go feta e e neetsweng, fa go tlhokega.
- O se ka wa kwala leina mo pampiring ya dipotso.
| KAROLO A: DINTLHA TSA DEMOKRAFI | |
| DIPOTSO | DIKARABO |
| 1. Dingwaga tsa mme | ___ dingwaga |
| 2. Seemo sa lenyalo | a. Nosi b. Nyetse c. O tlhadilwe d. Motlholagadi |
| 3. Maemo a thuto | a. Ga ke na thuto ya semmuso ya Poraemari b. Sekontari c. Dithuto tsa Boraro |
| 4. Seemo sa tiro | a. O thapilwe b. Ga a bereke c. Moithuti d. Modiri yo o sa tlhomamang |
| 5. Lotseno lwa lelapa | a. Lotseno lo lo kwa tlase (R1030.00 kgotsa bobtlana kgwedi -R6889) b. Lotseno lo lo magareng (R6890.00 -R48752.00 ka kgwedi) c. Lotseno lo lo kwa godimo (R48753.00 le godimo ka kgwedi) |
| 6. Palo ya bana | ___ |
| 7. Dingwaga tsa ngwana yo mmotlana | ___ dikgwedi/dingwaga |
| KAROLO YA B: KITSO LE TEMOGO YA GO ENTA | |
| 8. A o kile wa utlwa ka go entiwa ga bana pele? |
a. Ee b. nnyaa |
| 9. O bona kae tshedimosetso ya go enta? |
a. Tleliniki b. Bookelo c. Bobegakgang d. Modiri wa Pholo wa Baagi e. Lelapa f. Tse dingwe-------------tlhalosa |
| 10. A o itse thulaganyo e e akanyediwang ya go enta ngwana wa gago? | a. Ee b. nnyaa |
| 11. A o dumela gore go enta go thibela malwetse a a masisi? | a. Ee b. nnyaa |
| 12. Naya bolwetse bo le bongwe jo bo thibelwang ke moento/go entiwa ga bana. |
------------------------------- |
| 13. A o amogetse bukana ya go enta ngwana wa gago? | a. Ee b. nnyaa |
| KAROLO C: DIKGORELO TSA GO FITLHELELA MOENTO | |
| 14. Ke dikgwetlho dife tse o kopanang le tsone fa o isa ngwana wa gago go ya go entiwa? (Tshwaya tsotlhe tse di maleba) | a. Sekgala go ya kwa tleleniking se kgakala thata b. Ditshenyegelo tse di kwa godimo tsa dipalangwa c. Dinako tse ditelele tsa go leta kwa tleleniki d. Badiri ba ba seng botsalano kgotsa badiri ba tlhokomelo ya boitekanelo e. Go tlhoka tshedimosetso ya gore o ka ya leng le kae f. Tlhaelo ya moento kwa tleleniki g. Poifo ya ditlamorago tsa mekento h. Ditumelo tsa bodumedi kgotsa tsa setso kgatlhanong le mekento nna. Tse dingwe (tlhalosa) ___ i. Epe |
| 15. A o kile wa foswa ke go entiwa go go rulagantsweng ga ngwana wa gago? | a. Ee b. Nnyaa |
| 16.Fa karabo e e fa godimo e le ee, lebaka le legolo la go tlhoka go enta e ne e le eng? | ___ |
| 17. Mathata a matlole (sekao, ditshenyegelo tsa dipalangwa,) a nkgoreletsa go fitlhelela ditirelo tsa go enta. | a. Ee b. nnyaa |
| KAROLO D: DINTLHA TSA MOTLHOKO TSA LEFELO LA TLHOKOMELO YA BOITEKANELO, BOITEMOGELO | |
| 18.O leta lobaka lo lo kana kang kwa tleliniki go bona ditirelo tsa go entiwa? | a. Ka fa tlase ga metsotso e le 30 b. Metsotso e le 30 – ura e le 1 c. Go feta ura e le 1 d. Diura di feta 3 |
| 19. O ka lekanya jang boikutlo jwa badiri ba tlhokomelo ya kalafi? | a. O botsalano thata b. Go se tseye letlhakore c. Ga a botsalano |
| 20. A o kile wa kgaphelwa thoko ka ntlha ya gore mekento e ne e seyo? | a. Ee b.Nnyaa |
| 21. Badiri ba tlhokomelo ya boitekanelo ba neelana ka thotloetso le thuto e e lekaneng ka ga go enta bana. | a. Ee b. Nnyaa |
| 22. A o ikutlwa gore tleleniki e go naya tshegetso e e lekaneng go go thusa go fitlhelela ditirelo tsa go enta? | a. Ee b. Nnyaa |
| 23. A o amogetse letlha la ketelo e e latelang? | a. Ee b. Nnyaa |
| 24. A o amogetse thuto ka ga diphetogo tse di ka nnang teng tse di sa siamang morago ga go enta? | a. Ee b. Nnyaa |
| 25. A o itsisitswe ka ketelo e e latelang ke modiri wa tlhokomelo ya boitekanelo? | a. Ee b. Nnyaa |
| 26. A diura tsa tiro tsa tleliniki di tshwanela thulaganyo ya gago ya go isa ngwana wa gago go ya go entiwa? | a. Ee b. Nnyaa |
Appendix 5: Request letter to conduct a research study

- To Whom It May Concern
- Subject: REQUEST FOR PERMISSION TO CONDUCT RESEARCH AT SELECTED TERTIARY HOSPITAL
- We are final-year pharmacy students from Sefako Makgatho Health Sciences University. We are writing to you requesting permission to conduct our study exploring the challenges faced by mothers in accessing childhood vaccination services in South Africa.
- We would greatly appreciate your support and guidance in this matter. Please let us know if any additional information is required.
- Our contact details are as follows:
- Maranda Vhulenda: vhulenda169@gmail.com
- Chawane Tinyiko: tinyikochawane780@gmail.com
- Mphaphuli Hakhakhi: mphaphulihakhakhi60@gmail.com
-
Ndwa Lotavha: fnndwa@gmail.com
- Best Regards SMU Bpharm 4 students
Appendix 6: INFORMED CONSENT
| SEFAKO MAKGATHO HEALTH SCIENCES UNIVERSITY ENGLISH CONSENT FORM |
- Statement concerning participation in a Research Project
- Name of Study: Investigation of the challenges faced by mothers in accessing childhood immunisation services at the academic hospital in Gauteng, South Africa
- I have read the information on the aims and objectives of the proposed study and was provided the opportunity to ask questions and given adequate time to rethink the issue. The aim and objectives of the study are sufficiently clear to me. I have not been pressurized to participate in any way.
- I am aware that am going to complete the questionnaire. I am aware that this material may be used in scientific publications which will be electronically available throughout the world. I consent to this provided that my name / and identity number are not revealed.
- I understand that participation in this study is completely voluntary and that I may withdraw from it at any time and without supplying reasons. I know that this Study has been approved by the Sefako Makgatho University Research Ethics Committee (SMUREC). I am fully aware that the results of this Study will be used for scientific purposes and may be published. I agree to this, provided my privacy is guaranteed.
- I hereby give consent to participate in this Study.
- ............................................................ …………………………………………
- Name of Respondent Signature of Respondent
- ...................................... ....................................... .......................................
- Place Date Witness
- ___________________________________________________________________
- Statement by the Researcher
- I provided verbal written information regarding this Study.
- I agree to answer any future questions concerning the Study as best as I am able.
- I will adhere to the approved protocol.
- .................................... ................................. ......................... ......................................
- Name of Researcher Signature Date Place
Appendix 7: GEORGE MUKHARI’S APPROVAL LETTER

Appendix 8: SMU SCHOOL OF PHARMACY APPROVAL LETTER

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