Submitted:
03 October 2025
Posted:
20 October 2025
You are already at the latest version
Abstract
Keywords:
1. Introduction
2. Literature Review
2.1. Scientific Siting of Medical Facilities
2.2. Optimization of Emergency Medical Resources
2.3. Research Gap
| Reference | Major factors in the model | Problem Type | Decision | Model Type | Multi Period | Multi Objective | ||||||
| Cost | Time | Risk | Resources | L/A | R | In | C | UC | ||||
| Chang et al.(2023) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | MILP | ✓ | ✓ | ||
| Peng et al.(2023) | ✓ | ✓ | ✓ | ✓ | ✓ | MILP | ✓ | ✓ | ||||
| Liu et al. (2019) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | LP | ✓ | ||||
| Deng et al.,(2023) | ✓ | ✓ | ✓ | ✓ | ✓ | BLPM | ✓ | |||||
| Enayati et al.,(2021) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | MILP | ✓ | ||||
| Wang et al. (2022) | ✓ | ✓ | ✓ | ✓ | ✓ | MILP | ✓ | ✓ | ||||
| Alshurideh(2022) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | BLPM | ✓ | ✓ | |||
| Hao et al., (2022) | ✓ | ✓ | ✓ | ✓ | ✓ | MILP | ||||||
| Toorajipour(2021) | ✓ | ✓ | ✓ | ✓ | ✓ | LP | ✓ | ✓ | ||||
| Shahparvari et al., 2022 | ✓ | ✓ | ✓ | ✓ | ✓ | MINLP | ✓ | |||||
| Tirkolaee et al., (2023) | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | FMO | ✓ | ✓ | |||
| This study | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ | MILP | ✓ | ||
3. Background to the Issue


4.1. Model Parameters
4.1.1. Sets
4.1.2. Parameters
4.1.3. Decision Variables
4.2. Mathematical Model
5. Solution Approaches
5.1. PSO Based Solution Method
5.1.1. Solution Representation and Velocity Updating Strategy
5.1.2. Improved PSO Algorithm
5.1.3. General Procedure of PSO
| Algorithm 1: Particle swarm optimization (PSO) | |
| Require: | n, numParticle, max_gen,c1,c2,r1,r2 //n is the number of iteration; numParticle is the number of particles; max_gen is the maximum number of iterations; c1 and c2 are the acceleration weights; r1 and r2 are learning factors; |
| Result: | The objective value |
| 1: |
Define particle_gbest, particle_pbest[numParticle], particle_temp[numParticle], // each particle is a class which contains 5 data members, the position(alp, zet) and the velocity of particle(v_alp, v_zet) and the fitness; particle_gbest is used to store the best position of the whole swarm; particle_pbest is used to store the best position of a single particle; particle_temp is used to store current position of a single particle |
| 2: | Initialize the swarm |
| 3: | For all nnumParticle |
| 4: | Evaluate fitness of particle_temp[n] by solving model |
| 5: | particle_pbest ← particle_temp[n] |
| 6: | If particle_pbest[n].fitness < particle_gbest[n].fitness |
| 7: | particle_gbest ← particle_pbest[n] |
| 8: | End if |
| 9: | End for |
| 10: | pso_index←1 |
| 11: | While(pso_index<max_gen) |
| 12: | For all nnumParticle |
| 13: | particle_temp[n].v_alp←wn*particle_temp[n].v_alp+c1*r1*(particle_pbest[n].alp-particle_temp[n].alp)+c2*r2*(particle_gbest.alp–particle_temp[n].alp) |
| 14: | particle_temp[n].v_zet←wn*particle_temp[n].v_zet+c1*r1*(particle_pbest[n].zet-particle_temp[n].zet)+c2*r2*(particle_gbest.zet–particle_temp[n].zet) |
| 15: | If particle_temp[n].alp < alpmin |
| 16: | particle_temp[n].alp = alpmin |
| 17: | Else if particle_temp[n].alp > alpmax |
| 18: | particle_temp[n].alp = alpmax |
| 19: | End if |
| 20: | If particle_temp[n].zet < zetmin |
| 21: | particle_temp[n].zet = zetmin |
| 22: | Else if particle_temp[n].zet > zetmax |
| 23: | particle_temp[n].zet = zetmax |
| 24: | End if |
| 25: | Evaluate fitness of particle_temp[n] by solving model |
| 26: | If particle_temp[n].fitness < particle_pbest[n].fitness |
| 27: | particle_pbest[n] ← particle_temp |
| 28: | End if |
| 29: | If particle_temp[n].fitness < particle_gbest.fitness |
| 30: | particle_gbest ← particle_temp |
| 31: | End if |
| 32: | End for |
| 33: | pso_index++ |
| 34: | End while |
| 35: | Return the objective value |
5.2. VNS Based Solution Method
5.2.1. Solution Representation
5.2.2. Initial Solution
5.2.3. Neighborhood Structures


| Algorithm 2: Variable Neighborhood Descent (VND) | |
| Require: | best_solution, temp_solution, l←1, //best_solution is the optimal solution and temp_solution is the current solution, l is used to record the neighborhood structure |
| 1: | temp_solution←best_solution |
| 2: | While(true) |
| 3: | switch(l) |
| 4: | case 1: |
| neighborhood_one(temp_solution) | |
| 5: | If(temp_solution.fitness<best_solution.fitness) |
| 6: | best_solution←temp_solution; |
| 7: | l = 0; |
| 8: | End if |
| 9: | break; |
| 10: | case 2: |
| 11: | neighborhood_two(temp_solution) |
| 12: | If(temp_solution.fitness<best_solution.fitness) |
| 13: | best_solution←temp_solution; |
| 14: | l = 0; |
| 15: | End if |
| 16: | break; |
| 17: | case 3: |
| 18: | neighborhood_three(temp_solution) |
| 19: | If(temp_solution.fitness<best_solution.fitness) |
| 20: | best_solution←temp_solution; |
| 21: | l = 0; |
| 22: | End if |
| 23: | break; |
| 24: | case 4: |
| 25: | neighborhood_four(temp_solution) |
| 26: | If(temp_solution.fitness<best_solution.fitness) |
| 27: | best_solution←temp_solution; |
| 28: | l = 0; |
| 29: | End if |
| 30: | break; |
| 31: | default; |
| 32: | return; |
| 33: | l++; |
| 34: | End while |
5.2.5. Shaking Procedure

5.2.6. Variable Neighborhood Search
| Algorithm 3: Variable Neighborhood Search(VNS) | |
| Require: |
max_gen, current_solution, best_solution, iteration=0, max_gen=10 //max_gen is the maximum number of iterations, best_solution is the optimal solution and current_solution is current solution |
| Result: | Objective value |
| 1: | best_solution←Initial solution |
| 2: | While (iteration<max_gen) |
| 3: | current_solution←best_solution |
| 4: | shaking(current_solution) |
| 5: | Variable neighborhood descent(current_solution) |
| 6: | If(current_solution.fitness < best_solution.fitness) |
| 7: | best_solution←current_solution |
| 8: | iteration = 0; |
| 9: | End if |
| 10: | Iteration++; |
| 11: | End while |
6. Numerical Experiments
6.1. Generation of Test Instances
6.2. Performance of Two Heuristics
| Cases ID | CPLEX | PSO | Comparison | VNS | Comparison | |||||
| A4-2-4-4-4-2-2-5-1 | 584915 | 7.5 | 584915 | 16.2 | 2.16 | 0.00% | 584915 | 18.7 | 2.49 | 0.00% |
| A4-2-4-4-4-2-2-5-2 | 604314 | 7.8 | 604314 | 17.5 | 2.24 | 0.00% | 604314 | 20.8 | 2.67 | 0.00% |
| A4-2-4-4-4-2-2-5-3 | 622280 | 8.2 | 622280 | 19.2 | 2.34 | 0.00% | 622280 | 22.6 | 2.76 | 0.00% |
| Avg. | 603836 | 7.8 | 603836 | 17.6 | 2.25 | 0.00% | 603836 | 20.7 | 2.64 | 0.00% |
| A4-2-6-6-4-2-2-10-1 | 587795 | 13.1 | 587795 | 27.9 | 2.13 | 0.00% | 587795 | 24.8 | 1.89 | 0.00% |
| A4-2-6-6-4-2-2-10-2 | 555550 | 14.5 | 555550 | 29.4 | 2.03 | 0.00% | 555550 | 22.8 | 1.57 | 0.00% |
| A4-2-6-6-4-2-2-10-3 | 568258 | 12.9 | 568258 | 25.9 | 2.01 | 0.00% | 568258 | 23.2 | 1.80 | 0.00% |
| Avg. | 570534 | 13.5 | 570534 | 27.7 | 2.06 | 0.00% | 570534 | 23.6 | 1.75 | 0.00% |
| A6-2-4-4-4-2-2-5-1 | 734355 | 12.5 | 734355 | 17.2 | 1.38 | 0.00% | 734355 | 15.1 | 1.21 | 0.00% |
| A6-2-4-4-4-2-2-5-2 | 714710 | 13.5 | 714710 | 18.5 | 1.37 | 0.00% | 714710 | 18.8 | 1.39 | 0.00% |
| A6-2-4-4-4-2-2-5-3 | 693315 | 14.1 | 693315 | 17.6 | 1.25 | 0.00% | 693315 | 16.2 | 1.15 | 0.00% |
| Avg. | 714127 | 13.4 | 714127 | 17.8 | 1.33 | 0.00% | 714127 | 16.7 | 1.25 | 0.00% |
| A4-3-6-6-4-2-2-5-1 | 744445 | 28.8 | 744445 | 29.8 | 1.03 | 0.00% | 744445 | 26.2 | 0.91 | 0.00% |
| A4-3-6-6-4-2-2-5-2 | 708820 | 32.5 | 708820 | 30.5 | 0.94 | 0.00% | 708820 | 23.6 | 0.73 | 0.00% |
| A4-3-6-6-4-2-2-5-3 | 726788 | 31.5 | 726788 | 30.6 | 0.97 | 0.00% | 726788 | 22.8 | 0.72 | 0.00% |
| Avg. | 726684 | 30.9 | 726684 | 30.3 | 0.98 | 0.00% | 726684 | 24.2 | 0.79 | 0.00% |
| A6-3-6-6-4-2-2-10-1 | 842566 | 29.1 | 842566 | 25.8 | 0.89 | 0.00% | 842566 | 27.4 | 0.94 | 0.00% |
| A6-3-6-6-4-2-2-10-2 | 802506 | 29.8 | 802506 | 28.6 | 0.96 | 0.00% | 802506 | 25.6 | 0.86 | 0.00% |
| A6-3-6-6-4-2-2-10-3 | 800090 | 30.7 | 800090 | 27.8 | 0.91 | 0.00% | 800090 | 26.0 | 0.85 | 0.00% |
| Avg. | 815054 | 29.9 | 815054 | 27.4 | 0.92 | 0.00% | 815054 | 26.3 | 0.88 | 0.00% |
| A6-2-6-6-4-2-2-10-1 | 788898 | 45.4 | 788898 | 32.6 | 0.72 | 0.00% | 788898 | 34.5 | 0.76 | 0.00% |
| A6-2-6-6-4-2-2-10-2 | 737790 | 49.6 | 737790 | 34.5 | 0.70 | 0.00% | 737790 | 30.8 | 0.62 | 0.00% |
| A6-2-6-6-4-2-2-10-3 | 739632 | 48.5 | 739632 | 33.6 | 0.69 | 0.00% | 739632 | 35.6 | 0.73 | 0.00% |
| Avg. | 755440 | 47.8 | 755440 | 33.6 | 0.70 | 0.00% | 755440 | 33.6 | 0.70 | 0.00% |
| Cases ID | CPLEX | PSO | Comparison | VNS | Comparison | |||||
| A8-2-8-10-4-2-2-20-1 | 1077630 | 458.5 | 1079634 | 105.4 | 0.23 | 0.19% | 1081634 | 96 | 0.21 | 0.37% |
| A8-2-8-10-4-2-2-20-2 | 1045665 | 498.6 | 1055665 | 118.2 | 0.24 | 0.96% | 1047665 | 82.5 | 0.17 | 0.19% |
| A8-2-8-10-4-2-2-20-3 | 1004454 | 525.2 | 1012754 | 119.4 | 0.23 | 0.83% | 1005454 | 92.6 | 0.18 | 0.10% |
| Avg. | 1042583 | 494.1 | 1049351 | 114.3 | 0.23 | 0.66% | 1044918 | 90.4 | 0.18 | 0.22% |
| A8-4-8-15-4-2-2-20-1 | 1111434 | 926.5 | 1116434 | 136.5 | 0.15 | 0.45% | 1114634 | 108.2 | 0.12 | 0.29% |
| A8-4-8-15-4-2-2-20-2 | 1228565 | 896.9 | 1230565 | 158.6 | 0.18 | 0.16% | 1229995 | 112.5 | 0.13 | 0.12% |
| A8-4-8-15-4-2-2-20-3 | 1240855 | 883.8 | 1244455 | 165.8 | 0.19 | 0.29% | 1241155 | 115.9 | 0.13 | 0.02% |
| Avg. | 1193618 | 902.4 | 1197151 | 153.6 | 0.17 | 0.30% | 1195261 | 112.2 | 0.12 | 0.14% |
| A8-4-8-20-4-2-2-20-1 | 1409562 | 2620.2 | 1410885 | 345.3 | 0.13 | 0.09% | 1415620 | 172.4 | 0.07 | 0.43% |
| A8-4-8-20-4-2-2-20-2 | 1312520 | 2831.5 | 1317520 | 410.2 | 0.14 | 0.38% | 1319520 | 171.8 | 0.06 | 0.53% |
| A8-4-8-20-4-2-2-20-3 | 1325668 | 2450.6 | 1329256 | 478.8 | 0.20 | 0.27% | 1335668 | 160.2 | 0.07 | 0.75% |
| Avg. | 1349250 | 2634.1 | 1352553 | 411.4 | 0.16 | 0.25% | 1356936 | 168.1 | 0.06 | 0.57% |
| Cases ID | CPLEX | PSO | VNS | Comparison | ||||
| A10-5-8-20-4-2-2-30-1 | - | >7200 | 1552354 | 716.9 | 1495226 | 256.8 | 0.36 | 3.82% |
| A10-5-8-20-4-2-2-30-2 | - | >7200 | 1511435 | 537 | 1495035 | 288.7 | 0.35 | 1.10% |
| A10-5-8-20-4-2-2-30-3 | - | >7200 | 1624352 | 612.1 | 1606490 | 276.2 | 0.34 | 1.11% |
| Avg. | - | >7200 | 1562714 | 622 | 1532250 | 273.9 | 0.35 | 1.99% |
| A10-5-8-20-4-2-2-50-1 | - | >7200 | 1499535 | 923.8 | 1472636 | 584.6 | 0.63 | 1.83% |
| A10-5-8-20-4-2-2-50-2 | - | >7200 | 1446548 | 834.2 | 1392300 | 430.1 | 0.52 | 3.90% |
| A10-5-8-20-4-2-2-50-3 | - | >7200 | 1529066 | 1267 | 1499024 | 577.6 | 0.46 | 2.00% |
| Avg. | - | >7200 | 1491716 | 1008.3 | 1454653 | 530.8 | 0.54 | 2.55% |
| A10-5-8-25-4-2-2-30-1 | - | >7200 | 1773460 | 791.4 | 1693460 | 325.8 | 0.29 | 4.72% |
| A10-5-8-25-4-2-2-30-2 | - | >7200 | 1777342 | 494.1 | 1694352 | 297.3 | 0.48 | 4.90% |
| A10-5-8-25-4-2-2-30-3 | - | >7200 | 1806532 | 882.5 | 1778904 | 312.3 | 0.29 | 1.55% |
| Avg. | - | >7200 | 1785778 | 722.7 | 1722239 | 311.8 | 0.35 | 3.69% |
| A10-5-8-25-4-2-2-50-1 | - | >7200 | 1928654 | 2055.5 | 1908654 | 671.2 | 0.33 | 1.05% |
| A10-5-8-25-4-2-2-50-2 | - | >7200 | 1900541 | 1521.2 | 1883541 | 623.7 | 0.41 | 0.90% |
| A10-5-8-25-4-2-2-50-3 | - | >7200 | 1994455 | 2140.1 | 1908026 | 673.0 | 0.31 | 4.53% |
| Avg. | - | >7200 | 1941217 | 1905.6 | 1900074 | 656.0 | 0.35 | 2.17% |
6.3. Large-Scale Experiments
7. Conclusions
Conflicts of Interest
Author Contributions
Data Availability Statement
Acknowledgments
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