1. Introduction
Mental health disorders represent a growing challenge for public health systems globally, affecting millions of people in terms of quality of life, work productivity and general well-being [
1,
2,
3]. According to recent data from the World Health Organization (WHO), approximately 1 in 8 people worldwide, or 970 million individuals, suffer from a mental disorder. Among the most common are anxiety disorders, which affect more than 301 million people, and depressive disorders, with a prevalence of more than 280 million cases worldwide [
4]. In the Spanish context, the prevalence is 27.4%, with anxiety disorder being the most common mental health problem, affecting 6.7% of the Spanish population [
5,
6].
To address these challenges, effective treatment of mental disorders is crucial, with day hospitals emerging as a key outpatient treatment strategy. They provide a model of intervention that combines the intensity of inpatient care with the flexibility of outpatient treatment, allowing patients to receive specialized care while remaining integrated in their social environment [
7,
8]. In contrast to full hospitalization, day hospitals provide a personalized intervention that includes individual and group therapies and a multidisciplinary approach. Studies such as that of Vranješ, J., Petrić, D., Juretić, T. and Tovilović, Z have shown that this approach can be very effective, finding that day hospital programs significantly reduce psychiatric symptoms and improve patients’ treatment satisfaction and quality of life compared to traditional outpatient treatment [
9]. This approach not only optimizes treatment but also facilitates a more complete and sustainable recovery [
7,
8,
9,
10,
11,
12].
These centers have demonstrated the effectiveness of treating a variety of disorders [
13], such as mood disorders (e.g., major depression and bipolar disorder), using therapies such as cognitive behavioral therapy and interpersonal therapy to address symptoms and improve emotional regulation [
14,
15]. Anxiety disorders, including generalized anxiety disorder and panic disorder, are also addressed through graded exposure and stress management techniques. Psychotic disorders, such as schizophrenia, are managed with a combination of antipsychotic medication and psychoeducational and occupational therapy [
16,
17], while eating disorders, such as anorexia and bulimia, are treated with food-focused cognitive behavioral therapy and family therapy [
18,
19]. In addition, personality disorders, such as borderline personality disorder, are addressed with dialectical behavioral therapy to develop emotional regulation and interpersonal relationship management skills [
20,
21,
22].
Response to mental health treatment depends not only on the therapeutic intervention, but also on socio-demographic factors that may influence the course and effectiveness of treatment. Previous research has shown that variables such as gender, age, educational level and employment have a significant impact on treatment outcomes [
23,
24,
25]. For example, studies have indicated that women tend to seek treatment more frequently and often report greater symptom severity in depressive and anxiety disorders compared to men [
23,
26]. Age also plays an important role; older adults often face unique challenges such as comorbidity with physical illness and stigmatization, which can affect the effectiveness of interventions [
25,
27].
Educational level has been associated with individuals’ ability to access and benefit from treatment, as those with more education tend to have a better understanding of their disorders and greater adherence to treatment recommendations [
25].
Finally, employment status also plays a role; those who are employed tend to have greater social support and a daily structure that may facilitate recovery, while unemployment may be associated with a higher risk of mental health deterioration [
27].
In this context, the present study focuses on evaluating the efficacy of the Mental Health Day Hospital of the University Hospital of Burgos. This study seeks to evaluate the efficacy of the Day Hospital intervention model and to analyze how various socio-demographic factors influence the course of and response to treatment. The relevance of this study lies in its potential to provide empirical evidence to support the effectiveness of day hospitals as a treatment strategy, as well as to offer a deeper understanding of how individual patient characteristics affect treatment outcomes. The findings will not only contribute to the improvement of mental health intervention programs but will also facilitate the personalization of treatments to maximize their impact and improve patients’ quality of life.
2. Materials and Methods
2.1. Study Design
This was a retrospective, longitudinal, single-center study, which used the database accumulated up to 2022, corresponding to the last 27 years of the Mental Health Day Hospital of the University Hospital of Burgos. This database was subjected to an exhaustive cleaning process to guarantee the consistency and validity of the information. This process included the digitalization of paper records and a thorough review of clinical histories in order to complete missing data and correct possible inconsistencies. The main objective of the study was to evaluate the effectiveness of the service in improving the pathologies treated.
2.2. Sample Size and Participants
The target population of the study comprised all psychiatric patients over 18 years of age referred to the Mental Health Day Hospital of the University Hospital of Burgos, a service that acts as an intermediate step between outpatient consultations and hospitalization, providing intensive and specialized care to patients with various psychiatric pathologies.
The total sample included 1629 patients registered in the Day Hospital database who presented complete information for the variables of interest. No specific sampling was applied, since the aim was to analyze the totality of the data available in the database in order to obtain a comprehensive view of the effectiveness of the service.
2.3. Procedure
Data collection was carried out exhaustively and systematically over the last 27 years, following a specific methodology in the admission and treatment of patients.
Upon receipt of the patient’s referral to the service, an assessment of the patient’s motivation and the urgency of the treatment needed was made, to subsequently schedule an initial appointment for the complete assessment.
At this initial appointment, a comprehensive initial assessment was performed, through a psychiatric, psychological, nutritional and social evaluation, with the patient in some cases with family members, using structured interviews and other standardized assessment tools.
Subsequently, an individualized therapeutic project was developed, through the design of a specific treatment plan for each patient, based on the results of the initial evaluations. A therapeutic contract was then formalized, establishing the treatment objectives and the responsibilities of both the patient and the medical team.
For follow-up and evaluation, daily psychology, psychiatry and social work consultations were held to monitor the evolution of each patient. There was also a final evaluation of the effectiveness of the treatment, through the application of post-treatment psychological tests and adjustments to the therapeutic plan as needed.
2.4. Variables and Assessment Tools
Throughout the study, information was collected on several variables, measured using the following assessment tools:
Sociodemographic information: Gender and age. Each patient was classified as male or female, and age at admission to the service was collected.
Duration of treatment: Measured in days, from admission to discharge from the day hospital.
Main psychiatric diagnosis: Patients were diagnosed, following the DSM-IV Diagnostic Manual, according to the type of psychiatric pathology that caused their admission to the service. The pathologies were classified into mood disorders (major depression, dysthymia, etc.), substance use disorders (substance dependence, alcoholism, etc.), eating disorders (anorexia nervosa, bulimia nervosa, etc.), anxiety disorders (panic disorder, generalized anxiety disorder, etc.) and schizophrenia and other psychotic disorders (schizoaffective disorder, etc.).
Psychological and psychopathological symptoms: Assessed using the Symptom Checklist-90-R (SCL-90-R), a 90-item self-report scale designed to assess a wide range of psychological problems and symptoms of psychopathology. The items are organized into nine primary dimensions, somatization, obsession-compulsion, interpersonal sensitivity, depression, anxiety, hostility, phobic anxiety, paranoid ideation, and psychoticism. Higher scores on each of the dimensions imply greater number and severity of symptoms.
Anxiety: Assessed by the State-Trait Anxiety Inventory (STAI), a 40-item questionnaire that assesses two types of anxiety, state-anxiety (how the patient feels at a given moment), and trait-anxiety (how the patient feels generally). Higher scores mean higher levels of anxiety.
Locus of Control: Assessed by the Locus of Control Scale (LCS), a 29-item questionnaire that measures differentiating between an internal locus of control (belief that the patient controls his or her own destiny), and an external locus of control (belief that external factors or fate control the outcome of the patient’s events). Higher scores imply a greater internal locus, while lower scores imply a greater external locus—Assertiveness: assessed by the Rathus Assertiveness Schedule (RAS), a 30-item scale that assesses patients’ ability to express their feelings, stand up for their rights, and act in a socially appropriate manner without excessive anxiety. Higher scores mean greater assertiveness.
Impulsiveness: Assessed by The Barratt Impulsiveness Scale-11 (BIS-11), a 30-item self-report scale designed to assess different aspects of impulsiveness, including cognitive and motor impulsiveness and lack of planning, as well as total score. Higher scores on the dimensions and on the total scale mean higher impulsiveness.
Self-esteem: Assessed by the Rosenberg Self-Esteem scale (RSE), a 10-item questionnaire that measures the patient’s level of self-esteem. Higher scores mean a higher level of self-esteem.
2.5. Statistical Analysis
Statistical analysis was performed using SPSS version 30 (IBM-Inc., Chicago, IL, USA). All quantitative variables were subjected to the Kolmogorov-Smirnov normality test, and most of them followed a non-normal distribution.
First, the main baseline sociodemographic and clinical data were presented. Categorical variables were presented as a number of cases and percentage of the total, while quantitative variables were presented with medians and interquartile ranges. To analyze whether there were baseline differences between the different psychiatric pathology groups, comparisons were made using Chi-square tests and Kruskal-Wallis tests.
To analyze the correlation between the different quantitative variables in the study, Spearman correlations were used. To interpret the correlation indexes, those above ±.80 were considered very high, those between ±.60 and ±.80 were considered high, those between ±.40 and ±.60 were considered medium, those between ±.20 and ±.40 were considered low, and those below ±.20 were considered very low.
To analyze intra-group differences and thus be able to verify the evolution of the patients, and consequently the effectiveness of the service intervention, Wilcoxon signed-rank tests were performed. The pre-test scores, those obtained on admission to the service, were compared with the post-test scores, those obtained after completion of the intervention at discharge from the service.
To analyze the inter-group differences, the change score was calculated for each of the variables, finding the differences between the pre-test and post-test. Subsequently, the differences between the different groups of psychiatric pathologies were analyzed using Quade’s non-parametric ANCOVA tests, considering as covariates the initial pre-test scores obtained for each of the variables.
3. Results
3.1. Baseline Sample Characteristics
Table 1 shows the main sociodemographic and clinical characteristics of the study participants.
As can be seen in the table, more women (56.6%) than men (43.3%) were seen in the Day Hospital during this period. The mental disorders with the highest female predominance were eating disorders, while those with the highest male predominance were substance use disorders (67.9%).
In terms of age, the group of pathologies whose patients had the highest median age were mood disorders (43 years), while the lowest median age was for eating disorders (23 years).
On the other hand, treatment time in the Day Hospital was longer for anxiety disorders (108 days), and shorter for substance use disorders (79 days).
3.2. Correlations Between Variables
Table 2 shows the correlation between the main quantitative variables.
Age and duration of treatment correlated very poorly with most of the scores obtained in the different assessments performed.
The different symptoms of the SCL-90-R obtained statistically significant correlations, which were high and medium among them, medium with anxiety, medium and low with impulsivity, low with locus of control and with self-esteem, and low and very low with self-esteem.
The two measures of anxiety obtained statistically significant correlations, which were high with each other, low with locus of control, impulsivity and self-esteem, and very low with assertiveness.
Locus control also obtained statistically significant differences with the rest of the variables, which were all low and very low.
Assertiveness did not correlate statistically significantly with impulsivity but correlated poorly with self-esteem.
Finally, the different areas of impulsivity correlated significantly in a medium and low way with each other, and also in a low way with self-esteem.
3.3. Intra-Group Differences
Table 3 shows the intra-group differences between the evaluation performed on patients on admission to the unit and the evaluation performed on discharge from the service, thus proving the efficacy of the intervention.
As can be seen in the table, statistically significant differences were obtained in most of the variables (p<.001). After the intervention, patients in all mental disorder groups reduced all the symptoms of the SCL-90-R assessment, reduced anxiety levels, increased their internal locus, decreased their impulsivity, and increased their self-esteem.
However, hardly any significant results were obtained in the assertiveness assessment. In none of the groups did it increased, except in anxiety disorders, which did (p=.045).
Finally, statistically significant results were barely obtained in the enhancement of self-esteem. It only improved in the mood disorders group (p=.021).
3.4. Inter-Group Differences
Table 4 shows the inter-group differences for all the change scores obtained in the different assessments, thus verifying which groups of pathologies have improved more or less during the intervention at the Mental Health Day Hospital.
In most of the variables, no statistically significant differences (p>.05) were found between the groups, specifically in the SCL-90-R assessments of somatization, obsessions/compulsions, interpersonal sensitivity, depression, phobic anxiety, paranoid ideation and psychosis, and also in locus of control, assertiveness, self-esteem, motor impulsiveness, and lack of planning.
Regarding anxiety symptoms of the SCL-90R, patients with schizophrenia and other psychotic disorders improved less than those with mood disorders (p=.013) and with anxiety disorders (p=.003).
Regarding the hostility symptoms of the SCL-90R, patients with schizophrenia and other psychotic disorders also improved less than those with mood disorders (p=.029), with anxiety disorders (p=.003), and with eating disorders (p=.005).
As for state anxiety, patients with substance use disorders improved more than those with anxiety disorders (p=.002), and with schizophrenia and other psychotic disorders (p=.017). In addition, patients with eating disorders also improved more than those with anxiety disorders (P=.001), and those with schizophrenia and other psychotic disorders (p=.011).
Regarding trait anxiety, patients with anxiety disorders improved significantly less than those with mood disorders (p=.035), eating disorders (p<.0001), and schizophrenia and other psychotic disorders (p=.022), while patients with mood disorders also improved less than those with eating disorders (p=.028).
Finally, regarding cognitive impulsiveness, patients with mood disorders improved less than those with substance use disorders (p=.007), with anxiety disorders (p=.002), and with schizophrenia and other psychotic disorders (p=.002).
4. Discussion
Psychiatric disorders currently affect millions of people and represent a difficult challenge for public health worldwide [
1]. The main objective of this study was to evaluate the efficacy of the intervention model of the Burgos Mental Health Day Hospital, and to analyze how various sociodemographic factors may influence the evolution and response to treatment.
The results of this study provide an overview of the prevalence of mental disorders according to sex and age, as in other studies [
23,
24,
25]. The attention to a higher number of women compared to men is consistent with the literature, suggesting that certain disorders, especially eating disorders are more prevalent in women [
24]. On the other hand, the high prevalence of substance use disorders in men highlights the need for specific approaches to address gender differences in mental health.
The higher median age observed in patients with mood disorders, in contrast to the lower median in eating disorders, suggests that these disorders may have different developmental trajectories and require interventions tailored to patients’ life stages. This finding may also reflect the chronic nature of mood disorders, which often present later in life.
In terms of treatment duration, anxiety disorders require longer treatment time compared to substance use disorders. This could indicate that anxiety disorders are more complex and require a more intensive therapeutic approach.
Significant correlations between SCL-90-R variables indicate that anxiety, impulsiveness, and self-esteem symptoms are interrelated. However, the low correlation between age and duration of treatment with assessment scores suggests that treatment response may depend more on specific clinical factors than on demographic variables.
As in previous studies, The results obtained show the efficacy of the intervention [
9]. The reduction of symptoms in all mental disorder groups is an encouraging finding, although the lack of significant improvement in assertiveness and self-esteem, except in the mood disorder group, suggests that these aspects may require a more specific therapeutic approach.
The inter-group results reveal that, although most variables showed no significant differences between groups, patients with schizophrenia and other psychotic disorders showed less improvement in symptoms of anxiety and hostility compared to other groups. This highlights the need to develop more effective interventions for these patients, who may also benefit from more personalized treatments.
On the other hand, patients with substance use disorders and eating disorders showed significant improvements in anxiety-status, suggesting that the interventions applied may be more effective for these groups. However, patients with anxiety disorders showed less improvement in anxiety-trait, indicating that this group may need a more intensive and targeted approach to address their symptoms.
5. Conclusions
This study highlights the importance of considering differences in gender, age and type of mental disorder when designing interventions in mental health services. The findings obtained will allow us to optimize resources and tailor treatments to maximize therapeutic benefits for patients, thus contributing to improve the quality of psychiatric care in the Mental Health Day Hospital of Burgos. Despite the positive results in symptom reduction, further research is essential to optimize treatments and address the specific needs of each group of patients, especially those with more complex disorders.
Author Contributions
Conceptualization, P.O.-I.; methodology, P.O.-I., M.M.-A., X.R.G.-S. and B.S.-C.; data curation, Á.G.-B; formal analysis, Á.G.-B.; investigation, M.M.-A., X.R.G.-S. and B.S.-C.; writing—original draft preparation, S.N.-R. and Á.G.-B.; writing—review and editing, S.N.-R., P.O.-I., M.M.-A., X.R.G.-S., B.S.-C., Á.G.-B., J.J.G.-B. and J.G.-S.; visualization, S.N.-R., P.O.-I., Á.G.-B., J.J.G.-B. and J.G.-S.; supervision, J.J.G.-B. and J.G.-S.; project administration, J.J.G.-B. and J.G.-S. All authors have read and agreed to the published version of the manuscript.
Funding
This research received no external funding.
Institutional Review Board Statement
The study was conducted in accordance with the Declaration of Helsinki and approved by the Committee for Research with Medicines of the Burgos and Soria Health Area (Ref. CEIm 3192).
Informed Consent Statement
Informed consent was obtained from all subjects involved in the study.
Data Availability Statement
The complete database for this article is available. Requests for data access should be directed to the corresponding authors (agbustillo@ubu.es) or (jejavier@ubu.es).
Acknowledgments
The authors of this article are very grateful to all the patients who participated in this longitudinal observational study.
Conflicts of Interest
The authors declare no conflicts of interest.
References
- Fried EI. Studying Mental Health Problems as Systems, Not Syndromes. Curr. Dir. Psychol. Sci. 2022, 31(6), 500–508. [CrossRef]
- Pollock A, Campbell P, Cheyne J, Cowie J, Davis B, McCallum J, McGill K, Elders A, Hagen S, McClurg D, et al. Interventions to support the resilience and mental health of frontline health and social care professionals during and after a disease outbreak, epidemic or pandemic: a mixed methods systematic review. Cochrane Database of Syst. Rev. 2020, 2020(11). [CrossRef]
- Cebrino J, de la Cruz SP. Environmental, Health and Sociodemographic Determinants Related to Common Mental Disorders in Adults: A Spanish Country-Wide Population-Based Study (2006–2017). J. Clin. Med. 2020, 9, 2199. [CrossRef]
- World Health Organization. Mental Disorders. Available online: https://www.who.int/news-room/fact-sheets/detail/mental-disorders (accessed on 15 May 2025).
- Ministerio de Sanidad. Base de Datos Clínicos de Atención Primaria—BDCAP. Available online: https://www.sanidad.gob.es/estadEstudios/estadisticas/estadisticas/estMinisterio/SIAP/home.htm (accessed on 15 May 2025).
- Moitra M, Santomauro D, Collins PY, Vos T, Whiteford H, Saxena S, Ferrari AJ. The global gap in treatment coverage for major depressive disorder in 84 countries from 2000–2019: A systematic review and Bayesian meta-regression analysis. PLoS Med. 2022, 19(2). [CrossRef]
- Duarte D, Ramos L, Trindade AC, Gonçalves E. Psychiatric Day Hospital and Its Impact on Patients Clinical Stability: The Reality of Faro (Portugal) Unit. Open J. Psychiatr. 2018, 9(1), 15–22. [CrossRef]
- Smits ML, Feenstra DJ, Bales DL, Blankers M, Dekker JJM, Lucas Z, Kamphuis JH, Busschbach JJV, Verheul R, Luyten P. Day hospital versus intensive outpatient mentalization-based treatment: 3-year follow-up of patients treated for borderline personality disorder in a multicentre randomized clinical trial. Psychol. Med. 2022, 52(3), 485–495. [CrossRef]
- Vranješ J, Petrić D, Grahovac Juretić T, Tovilović Z. Quality of Life and Treatment Satisfaction of Hospitalized and Day Hospital Psychiatric Patients. Croat. Nurs. J. 2021. 5(1), 5–16. [CrossRef]
- Brañas A, Márquez P, Mas J, Merino A, Ruiz A, Catasús C, Hernández E, Fernández Liria A. Day Hospital designed to increase the ability to mentalize: 8 years of follow-up. Rev. Argent. Clin. Psic. 2019, 28(2), 115–126. [CrossRef]
- John S, Cohen D. Short Research Article: Opening a new CAMHS day hospital—does it affect inpatient admissions and does it help at all? Child Adolesc. Ment Health 2024, 29(3), 276–280. [CrossRef]
- González-Rodríguez A, Sanz N, Guàrdia A, Pedrero AA, Pérez DG, Fucho GF, Delgado L, Parra Uribe I, Monreal JA, Palao Vidal D, et al. Impact of day hospital care on adherence to psychiatric follow-up appointments and medications in patients with delusional disorder. Eur. Psychiatry 2021, 64(S1), S475–S476. [CrossRef]
- Doering S, Herpertz S, Hofmann T, Rose M, Imbierowicz K, Geiser F, Croy I, Weidner K, Rademacher J, Michalek S, et al. What Kind of Patients Receive Inpatient and Day-Hospital Treatment in Departments of Psychosomatic Medicine and Psychotherapy in Germany? Psychother. Psychosom. 2023, 92(1), 49–54. [CrossRef]
- Caratan S, Lovko SK, Ivrlač A, Goršić L, Matoš T. 20 years of daily hospital for non-psychotic disorders, organisational structure and treatment modalities. Eur. Psychiatry 2022, 65(S1), S751. [CrossRef]
- Doering S, Herpertz S, Pape M, Hofmann T, Rose M, Imbierowicz K, Geiser F, Bierling AL, Weidner K, Rademacher J, et al. The multicenter effectiveness study of inpatient and day hospital treatment in departments of psychosomatic medicine and psychotherapy in Germany. Front Psychiatry 2023, 14. [CrossRef]
- Vázquez-Bourgon J, Gómez Ruiz E, Hoyuela Zatón F, Salvador Carulla L, Ayesa Arriola R, Tordesillas Gutiérrez D, Crespo Facorro B. Differences between psychiatric disorders in the clinical and functional effectiveness of an acute psychiatric day hospital, for acutely ill psychiatric patients. Rev. Psiquiatr. Salud Ment. 2021. [CrossRef]
- Kostyuk GP, Burygina LA, Berezantsev AY, Surikova VV. The comparative analysis of clinical and social characteristics of patients with schizophrenia and organic mental disorders receiving care in partial inpatient units. Vestnik nevrologii, psihiatrii i nejrohirurgii (Bulletin of J. Neurol. Neurosurg. Psychiatry) 2021, 5, 394–403. [CrossRef]
- Dalle Grave R, Dametti L, Conti M, Bersan C, Dalle Grave A, Calugi S. Day-hospital enhanced cognitive behavior therapy for adults with eating disorders: Immediate and follow-up effects. Int. J. Eat. Disord. 2022, 55(1),125–130. [CrossRef]
- de Boer K, Johnson C, Wade TD, Radunz M, Fernando AN, Babb J, Stafrace S, Sharp G. A systematic review and meta-analysis of intensive treatment options for adults with eating disorders. Clin. Psychol. Rev. 2023, 106. [CrossRef]
- Gillespie C, Murphy M, Joyce M. Dialectical Behavior Therapy for Individuals With Borderline Personality Disorder: A Systematic Review of Outcomes After One Year of Follow-Up. J. Pers. Disord. 2022, 36(4), 431–454. [CrossRef]
- Flynn D, Kells M, Joyce M. Dialectical behaviour therapy: Implementation of an evidence-based intervention for borderline personality disorder in public health systems. Curr. Opin. Psychol. 2021, 37, 152–157. [CrossRef]
- Rudge S, Feigenbaum JD, Fonagy P. Mechanisms of change in dialectical behaviour therapy and cognitive behaviour therapy for borderline personality disorder: a critical review of the literature. J. Ment. Health 2020, 29(1), 92–102. [CrossRef]
- Rayner C, Coleman JRI, Purves KL, Carr E, Cheesman R, Davies MR, Delgadillo J, Hübel C, Krebs G, Peel AJ, et al. Sociodemographic factors associated with treatment-seeking and treatment receipt: cross-sectional analysis of UK Biobank participants with lifetime generalised anxiety or major depressive disorder. BJPsych. Open 2020, 7(6), e216. [CrossRef]
- Mills JA, Suresh V, Chang L, Mayes T, Croarkin PE, Trivedi MH, Strawn JR. Socioeconomic Predictors of Treatment Outcomes Among Adults With Major Depressive Disorder. Psychiatr. Serv. 2022, 73(9), 965–969. [CrossRef]
- Fonseca Barbosa J, Gama Marques J. The revolving door phenomenon in severe psychiatric disorders: A systematic review. Int. J. Soc. Psychiatry 2023, 69(5), 1075–1089. [CrossRef]
- Fonseca de Freitas D, Kadra-Scalzo G, Agbedjro D, Francis E, Ridler I, Pritchard M, Shetty H, Segev A, Casetta C, Smart SE. Using a statistical learning approach to identify sociodemographic and clinical predictors of response to clozapine. J. Psychopharmacol. 2022, 36(4), 498–506. [CrossRef]
- Blažinović I, Orlović I, Karlović D, Peitl V. Comparison of Clinical and Sociodemographic Characteristics of Patients with Schizophrenia Treated Stationary and at Day Hospital. Arch. Psychiatry Res. 2019, 55(2), 127–138. [CrossRef]
Table 1.
Baseline sociodemographic and clinical characteristics of the sample.
Table 1.
Baseline sociodemographic and clinical characteristics of the sample.
| |
Mood Disorders N = 377 (23.1%) |
Substance Use Disorders N = 349 (21.4%) |
Eating Disorders N = 334 (20.5%) |
Anxiety Disorders N = 291 (17.9%) |
Schizophrenia and other Psychotic Disorders N = 278 (17.1%) |
Total N = 1629 (100%) |
Sig. (p) |
| Gender |
|
|
|
|
|
|
< .001 |
|
Male, n (%) |
125 (33.2%) |
237 (67.9%) |
25 (7.5% |
138 (47.4%) |
182 (65.5%) |
707 (43,4%) |
|
Female, n (%) |
252 (66.8%) |
112 (32.1%) |
309 (92.5%) |
153 (52.6%) |
96 (34.5%) |
922 (56,6%) |
|
Age; Median (IQ) |
43.00 (33.00; 50.00) |
41.0 (34.00; 47.00) |
23.0 (18.00; 32.00) |
38.5 (28.00; 47.25) |
30.0 (23.0; 37.25) |
35.00 (25.00; 45.00) |
< .001 |
|
Duration of treatment; Median (IQ) |
107.00 (60.00; 149.50) |
79.00 (49.50; 107.00) |
105.00 (66.80; 141.50) |
108.00 (72.00; 144.00) |
102.00 (55.00; 143.00) |
98.00 (59.00; 137.00) |
< .001 |
|
SCL-90-R_SOM; Median (IQ) |
1.58 (.83; 2.33) |
1.16 (.58; 1.89) |
1.41 (.83; 2.25) |
1.75 (1.00; 2.67) |
.83 (.37; 1.33) |
1.33 (.67; 2.08) |
< .001 |
|
SCL-90-R_OBS; Median (IQ) |
2.20 (1.50; 2.80) |
1.50 (.90; 2.08) |
1.90 (1.20; 2.55) |
2.20 (1.50; 2.80) |
1.30 (.70; 2.00) |
1.80 (1.10; 2.50) |
< .001 |
|
SCL-90-R_IS; Median (IQ) |
1.89 (1.11; 2.56) |
1.22 (.77; 2.00) |
2.05 (1.33; 2.67) |
1.80 (1.22; 2.56) |
1.22 (.58; 2.05) |
1.67 (1.00; 2.33) |
< .001 |
|
SCL-90-R_DEP; Median (IQ) |
2.69 (1.85; 3.23) |
1.76 (1.08; 2.46) |
2.30 (1.46; 2.92) |
2.62 (1.86; 3.23) |
1.40 (.77; 2.23) |
2.15 (1.31; 2.92) |
< .001 |
|
SCL-90-R_ANX; Median (IQ) |
2.00 (1.20; 2.70) |
1.45 (.80; 2.10) |
1.70 (.90; 2.50) |
2.00 (1.30; 2.90) |
1.00 (.50; 1.90) |
1.60 (.90; 2.40) |
< .001 |
|
SCL-90-R_HOS; Median (IQ) |
.83 (.50; 2.00) |
.83 (.50; 1.67) |
1.33 (.66; 2.17) |
1.17 (.50; 2.29) |
.66 (.17; 1.24) |
1.00 (.50; 2.00) |
< .001 |
|
SCL-90-R_PA; Median (IQ) |
1.43 (.57; 2.17) |
.71 (.28; 1.42) |
.86 (0.29; 1.71) |
1.28 (.57; 2.33) |
.70 (.20; 1.29) |
1.00 (.42; 1.85) |
< .001 |
|
SCL-90-R_PI; Median (IQ) |
1.33 (.83; 2.17) |
1.33 (.70; 2.00) |
1.50 (.83; 1.50) |
1.50 (.83; 2.33) |
1.33 (.50; 2.05) |
1.33 (.81; 2.16) |
.007 |
|
SCL-90-R_PSY; Median (IQ) |
1.30 (.80; 2.00) |
1.10 (.60; 1.70) |
1.20 (.70; 1.90) |
1.50 (.80; 2.10) |
1.00 (.40; 1.64) |
1.20 (.70; 1.90) |
< .001 |
|
STAI_SAS; Median (IQ) |
83.00 (63.00; 94.00) |
73.00 (45.00; 89.00) |
80.00 (62.00; 93.00 |
85.00 (65.00; 96.00) |
67.00 (35.00; 83.00) |
78.00 (55.00; 92.00) |
< .001 |
|
STAI_TAS; Median (IQ) |
90.00 (70.00; 98.00) |
83.00 (62.25; 93.00) |
88.00 (70.00; 97.00) |
93.00 (75.00; 98.00) |
73.00 (40.00; 92.00) |
87.00 (62.00; 97.00) |
< .001 |
|
LCS; Median (IQ) |
12.00 (10.00; 14.00) |
11.00 (9.00; 13.00) |
12.00 (9.00; 14.00) |
12.00 (10.00; 15.00) |
11.00 (8.00; 13.00) |
12.00 (9.00; 14.00) |
< .001 |
|
RAS; Median (IQ) |
.00 (-8.75; 8.00) |
3.00 (-5.00; 10.00) |
2.00 (-7.00; 10.00) |
-1.00 (-10.00; 7.00) |
1.00 (-5.75; 8.75) |
1.00 (-7.00; 9.00) |
< .001 |
|
BIS-11_CI; Median (IQ) |
17.00 (14.00; 21.00) |
16.00 (13.00; 20.00) |
17.00 (13.00; 20.00) |
18.00 (14.00; 21.00) |
15.00 (12.00; 18.00) |
17.00 (13.00; 20.00) |
< .001 |
|
BIS-11_MI; Median (IQ) |
16.00 (12.00; 22.00) |
19.00 (12.50; 24.50) |
19.50 (14.00; 26.00) |
18.00 (12.00; 24.00) |
14.00 (10.00; 20.00) |
17.00 (12.00; 23.00) |
< .001 |
|
BIS-11_LP; Median (IQ) |
18.00 (14.00; 24.00) |
20.00 (14.00; 26.00) |
19.00 (13.00; 25.00) |
19.00 (15.00; 25.00) |
20.00 (16.00; 25.25) |
19.00 (14.00; 25.00) |
.035 |
|
BIS-11_Total; Median (IQ) |
52.00 (42.00; 63.00) |
56.00 (44.00; 70.00) |
56.00 (44.00; 65.00) |
54.00 (44.00; 67.00) |
51.00 (40.00; 60.00) |
54.00 (43.00; 65.00) |
.009 |
|
RSE; Median (IQ) |
26.00 (21.25; 31.00) |
27.00 (24.00; 30.75) |
24.00 (20.00; 28.00) |
27.00 (21.00; 30.00) |
28.00 (24.00; 31.25) |
26.00 (22.00; 31.00) |
.002 |
Table 2.
Spearman correlations between quantitative variables.
Table 2.
Spearman correlations between quantitative variables.
| |
Age |
Days treatment |
SCL-90R SOM |
SCL-90R OBS |
SCL-90R IS |
SCL–90R DEP |
SCL–90R ANX |
SCL–90R HOS |
SCL–90R PA |
SCL–90R PI |
SCL-90R PSY |
STAI SAS |
STAI TAS |
LCS |
RAS |
BIS-11 CI |
BIS-11 MI |
BIS-11 LP |
BIS-11 Total |
| Age |
− |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Days treatment |
.006 |
− |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| SCL-90-R_SOM |
.170***
|
.080**
|
− |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| SCL-90-R_OBS |
.109***
|
.101***
|
.661***
|
− |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| SCL-90-R_IS |
-.047 |
.087***
|
.554***
|
.735***
|
− |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| SCL-90-R_DEP |
.115***
|
.110***
|
.666***
|
.806***
|
.771***
|
− |
|
|
|
|
|
|
|
|
|
|
|
|
|
| SCL-90-R_ANX |
.110***
|
.080**
|
.744***
|
.781***
|
.720***
|
.814***
|
− |
|
|
|
|
|
|
|
|
|
|
|
|
| SCL-90-R_HOS |
-.095***
|
.026 |
.520***
|
.563***
|
.625***
|
.574***
|
.614***
|
− |
|
|
|
|
|
|
|
|
|
|
|
| SCL-90-R_PA |
.091***
|
.074**
|
.595***
|
.675***
|
.678***
|
.664***
|
.749***
|
.482***
|
− |
|
|
|
|
|
|
|
|
|
|
| SCL-90-R_PI |
,002 |
,020 |
.513***
|
.620***
|
.752***
|
.607***
|
.652***
|
.642***
|
.565***
|
− |
|
|
|
|
|
|
|
|
|
| SCL-90-R_PSY |
.105***
|
.057*
|
.616***
|
.729***
|
.744***
|
.735***
|
.778***
|
.607***
|
.670***
|
.736***
|
− |
|
|
|
|
|
|
|
|
| STAI_SAS |
.118***
|
.074**
|
.456***
|
.517***
|
.454***
|
.576***
|
.538***
|
.356***
|
.416***
|
.367***
|
.478***
|
− |
|
|
|
|
|
|
|
| STAI_TAS |
.041 |
.069**
|
.389***
|
.551***
|
.535***
|
.601***
|
.527***
|
.403***
|
.431***
|
.432***
|
.479***
|
.664***
|
− |
|
|
|
|
|
|
| LCS |
-.028 |
.051*
|
.224***
|
.237***
|
.256***
|
.265***
|
.245***
|
.199***
|
.189***
|
.251***
|
.233***
|
.207***
|
.239***
|
− |
|
|
|
|
|
| RAS |
-.010 |
-.071**
|
-.087***
|
-.204***
|
-.253***
|
-.208***
|
-.162***
|
-.019 |
-.219***
|
-.104***
|
-.172***
|
-.171***
|
-.190***
|
-.130***
|
− |
|
|
|
|
| BIS-11_CI |
.027 |
.016 |
.360***
|
.422***
|
.373***
|
.394***
|
.429***
|
.370***
|
.351***
|
.330***
|
.418***
|
.265***
|
.345***
|
.197***
|
-,032 |
− |
|
|
|
| BIS-11_MI |
-.021 |
-.096**
|
.352***
|
.327***
|
.368***
|
.346***
|
.426***
|
.512***
|
.293***
|
.418***
|
.382***
|
.230***
|
.304***
|
.176***
|
.090**
|
.476***
|
− |
|
|
| BIS-11_LP |
-.100***
|
-.068*
|
.158***
|
.160***
|
.201***
|
.148***
|
.173***
|
.250***
|
.137***
|
.249***
|
.229***
|
.095**
|
.158***
|
.067*
|
-,017 |
.339***
|
.366***
|
− |
|
| BIS-11_Total |
-.048 |
-.084**
|
.353***
|
.361***
|
.386***
|
.357***
|
.409***
|
.483***
|
.312***
|
.415***
|
.415***
|
.216***
|
.312***
|
.167***
|
,021 |
.679***
|
.815***
|
.743***
|
− |
| RSE |
.028 |
-.006 |
-.306***
|
-.389***
|
-.447***
|
-.439***
|
-.366***
|
-.296***
|
-.341***
|
-.334***
|
-.367***
|
-.335***
|
-.371***
|
-.174***
|
.227***
|
-.238***
|
-.253***
|
-.150***
|
-.273***
|
Table 3.
Wilcoxon signed rank tests to analyze intra-group differences.
Table 3.
Wilcoxon signed rank tests to analyze intra-group differences.
| |
Mood Disorders |
Substance Use Disorders |
Eating Disorders |
Anxiety Disorders |
Schizophrenia and other Psychotic Disorders |
| |
Pre-test Median |
Post-test Median |
Sig. (p) |
Pre-test Median |
Post-test Median |
Sig. (p) |
Pre-test Median |
Post-test Median |
Sig. (p) |
Pre-test Median |
Post-test Median |
Sig. (p) |
Pre-test Median |
Post-test Median |
Sig. (p) |
| SCL-90-R_SOM |
1.58 |
0.83 |
< .001 |
1.16 |
0.66 |
< .001 |
1.41 |
0.75 |
< .001 |
1.75 |
1.00 |
< .001 |
.83 |
0.42 |
< .001 |
| SCL-90-R_OBS |
2.20 |
1.40 |
< .001 |
1.50 |
1.00 |
< .001 |
1.90 |
1.20 |
< .001 |
2.20 |
1.40 |
< .001 |
1.30 |
0.80 |
< .001 |
| SCL-90-R_IS |
1.89 |
1.22 |
< .001 |
1.22 |
0.78 |
< .001 |
2.05 |
1.33 |
< .001 |
1.80 |
1.33 |
< .001 |
1.22 |
0.72 |
< .001 |
| SCL-90-R_DEP |
2.69 |
1.53 |
< .001 |
1.76 |
1.08 |
< .001 |
2.30 |
1.38 |
< .001 |
2.62 |
1.54 |
< .001 |
1.40 |
0.77 |
< .001 |
| SCL-90-R_ANX |
2.00 |
1.00 |
< .001 |
1.45 |
0.70 |
< .001 |
1.70 |
0.80 |
< .001 |
2.00 |
1.16 |
< .001 |
1.00 |
0.50 |
< .001 |
| SCL-90-R_HOS |
0.83 |
0.33 |
< .001 |
0.83 |
0.41 |
< .001 |
1.33 |
0.67 |
< .001 |
1.17 |
0.67 |
< .001 |
0.66 |
0.25 |
< .001 |
| SCL-90-R_PA |
1.43 |
0.57 |
< .001 |
0.71 |
0.42 |
< .001 |
0.86 |
0.29 |
< .001 |
1.28 |
0.64 |
< .001 |
0.70 |
0.29 |
< .001 |
| SCL-90-R_PI |
1.33 |
0.83 |
< .001 |
1.33 |
0.83 |
< .001 |
1.50 |
1.00 |
< .001 |
1.50 |
1.00 |
< .001 |
1.33 |
0.67 |
< .001 |
| SCL-90-R_PSY |
1.30 |
0.70 |
< .001 |
1.10 |
0.70 |
< .001 |
1.20 |
0.70 |
< .001 |
1.50 |
0.80 |
< .001 |
1.00 |
0.40 |
< .001 |
| STAI_SAS |
83.00 |
55.00 |
< .001 |
73.00 |
44.00 |
< .001 |
80.00 |
40.00 |
< .001 |
85.00 |
63.00 |
< .001 |
67.00 |
40.00 |
< .001 |
| STAI_TAS |
90.00 |
72.00 |
< .001 |
83.00 |
65.00 |
< .001 |
88.00 |
60.00 |
< .001 |
93.00 |
80.00 |
< .001 |
73.00 |
48.00 |
< .001 |
| LCS |
12.00 |
11.00 |
< .001 |
11.00 |
9.00 |
< .001 |
12.00 |
10.00 |
< .001 |
12.00 |
11.00 |
< .001 |
11.00 |
10.00 |
.013 |
| RAS |
0.00 |
3.00 |
.094 |
3.00 |
4.00 |
.194 |
2.00 |
3.00 |
.615 |
-1.00 |
0.50 |
.045 |
1.00 |
3.00 |
.620 |
| BIS-11_CI |
17.00 |
15.00 |
.002 |
16.00 |
12.50 |
< .001 |
17.00 |
14.00 |
.002 |
18.00 |
14.00 |
< .001 |
15.00 |
13.00 |
< .001 |
| BIS-11_MI |
16.00 |
14.00 |
< .001 |
19.00 |
14.00 |
< .001 |
19.50 |
15.00 |
< .001 |
18.00 |
12.00 |
< .001 |
14.00 |
11.00 |
< .001 |
| BIS-11_LP |
18.00 |
16.00 |
< .001 |
20.00 |
15.50 |
< .001 |
19.00 |
17.00 |
.010 |
19.00 |
17.50 |
.002 |
20.00 |
18.00 |
< .001 |
| BIS-11_Total |
52.00 |
44.00 |
< .001 |
56.00 |
44.00 |
< .001 |
56.00 |
47.00 |
< .001 |
54.00 |
45.00 |
< .001 |
51.00 |
44.00 |
< .001 |
| RSE |
26.00 |
29.00 |
.021 |
27.00 |
29.50 |
.063 |
24.00 |
23.00 |
.414 |
27.00 |
28.00 |
.127 |
28.00 |
29.00 |
.648 |
Table 4.
Quade’s non-parametric ANCOVA tests to analyze inter-groups differences.
Table 4.
Quade’s non-parametric ANCOVA tests to analyze inter-groups differences.
| |
Mood Disorders |
Substance Use Disorders |
Eating Disorders |
Anxiety Disorders |
Schizophrenia and other Psychotic Disorders |
F |
Sig. (p) |
| SCL-90-R_SOM |
-.42 |
-.33 |
-.50 |
-.42 |
-.25 |
2,050 |
.085 |
| SCL-90-R_OBS |
-.50 |
-.30 |
-.40 |
-.50 |
-.40 |
2,205 |
.067 |
| SCL-90-R_IS |
-.34 |
-.22 |
-.44 |
-.46 |
-.34 |
2,423 |
.057 |
| SCL-90-R_DEP |
-.69 |
-.46 |
-.69 |
-.77 |
-.46 |
1,225 |
.298 |
| SCL-90-R_ANX |
-.50 |
-.50 |
-.50 |
-.70 |
-.40 |
2,734 |
.028 |
| SCL-90-R_HOS |
-.33 |
-.34 |
-.50 |
-.34 |
-.33 |
2,747 |
.027 |
| SCL-90-R_PA |
-.42 |
-.14 |
-.28 |
-.29 |
-.28 |
1,611 |
.169 |
| SCL-90-R_PI |
-.33 |
-.33 |
-.33 |
-.33 |
-.50 |
1,728 |
.142 |
| SCL-90-R_PSY |
-.40 |
-.25 |
-.40 |
-.40 |
-.30 |
1,662 |
.157 |
| STAI_SAS |
-19.00 |
-22.00 |
-20.00 |
-15.00 |
-14.50 |
4,091 |
.003 |
| STAI_TAS |
-11.50 |
-11.00 |
-16.00 |
-7.00 |
-12.00 |
3,540 |
.007 |
| LCS |
.00 |
-1.00 |
-1.00 |
-2.00 |
-1.00 |
1,995 |
.093 |
| RAS |
1.00 |
1.00 |
.00 |
2.00 |
.00 |
0,724 |
.576 |
| BIS-11_CI |
-1.00 |
-1.00 |
-1.00 |
-3.00 |
-2.00 |
3,693 |
.006 |
| BIS-11_MI |
-2.00 |
-3.00 |
-2.00 |
-3.00 |
-2.00 |
2,243 |
.063 |
| BIS-11_LP |
-2.00 |
-4.00 |
-1.00 |
-1.00 |
-1.00 |
2,400 |
.059 |
| BIS-11_Total |
-4.00 |
-9.00 |
-5.00 |
-5.00 |
-5.00 |
1,539 |
.189 |
| RSE |
2.00 |
4.00 |
2.00 |
-2.50 |
.00 |
0,380 |
.822 |
|
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).