Submitted:
05 June 2025
Posted:
11 June 2025
You are already at the latest version
Abstract
Keywords:
1. Introduction
- Determine the rate and suitability of referrals and subsequent clinical impact.
- Quantify medicine optimization for patients who underwent medicine review.
- Explore patient experiences and feelings around referrals and their medicines.
- Explore ambulance healthcare professionals’ perceptions of the value of referral.
2. Materials and Methods
2.1. Context
2.2. Improvement Initiative
| Inclusion | Exclusion |
| Aged ≥ 65 | Aged < 65 |
| Face-to-face assessment by an ambulance clinician | No face-to-face contact |
| Primary reason for ambulance attendance was fall | Patient conveyed to hospital |
| Taking ≥ 1 medicine (prescribed or otherwise) | Not taking medicines |
| Fall in a residential address | Fall in public or patient is a care/nursing home resident |
| Registered with a local confederation GP | Registered with a GP outside the confederation |
| Non-urgent referral made | No referral made |
2.3. Service Evaluation
2.4. Stakeholder Surveys
2.4.1. Patient Survey
2.4.2. Ambulance Clinician Survey
2.5. Ethical Considerations
3. Results
3.1. Referral Rate, Suitability, and Clinical Impact
3.2. Medicine Optimisation
3.3. Patient Experiences and Feelings

3.4. Ambulance Healthcare Professional Perceptions
4. Discussion
4.1. Limitations
4.2. Future research
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
| SQUIRE | Standards for Quality Improvement Reporting Excellence (2.0) |
| CROSS | Checklist for Reporting of Survey Studies |
| CI | Confidence Interval |
| OR | Odds Ratio |
| IQR | Interquartile Range |
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| Objective | Measure | |
| Referral Rate, Suitability, and Clinical Impact | 1 | Referral rates |
| 2 | Referral appropriateness | |
| 3 | Fall and/or ambulance recurrence | |
|
Medicine Optimisation |
4 | Polypharmacy reduction. |
| 5 | Deprescribing of fall-risk medicines as per PrescQIPP [30] (Table S3) | |
| Patient Experiences | 6 | Change in emotions about their medicines post-review |
| 7 | Impact of specific review activities on emotions | |
|
Ambulance Staff Perceptions |
8 | Key indicators of medicine management difficulty |
| 9 | Perceived frequency of such cases | |
| 10 | Perceived value of pharmacist referral | |
| 11 | Influence of clinician demographics on referral value perception | |
| Case Demographic |
All referred n = 775 |
Received medicine review n = 340 (43.9%) |
Did not receive medicine review n = 435 (56.1%) |
| Age median (interquartile range) | 84 (77–89) | 84 (77–89) | 84 (77–90) |
| Patient fallen in last 12 months | |||
| Yes | 573 (73.9%) | 243 (71.5%) | 330 (75.9%) |
| No | 159 (20.5%) | 79 (23.2%) | 80 (18.4%) |
| Not recorded | 43 (5.6%) | 18 (5.3%) | 25 (5.7%) |
| Patient prescribed ≥4 medicines | 597 (77.0%) | 264 (77.6%) | 333 (76.6%) |
| Ambulance crew concerned about medicines | 173 (22.3%) | 64 (18.8%) | 109 (25.1%) |
| Time from referral to initial review decision median days (interquartile range) | 10 (4–27) | 9 (3–21) | 28 (10–109) |
| Case Demographic | Value |
| Frailty n (%) | |
| Severe | 86 (25.3%) |
| Moderate | 106 (31.2%) |
| Mild | 6 (1.8%) |
| Not frail | 128 (37.6%) |
| Not recorded | 14 (4.1%) |
| Pharmacist review type n (%) | |
| Face-to-face | 7 (2.1%) |
| Telephone | 77 (22.6%) |
| Notes based | 125 (36.8%) |
| Not recorded | 131 (38.5%) |
| Referral considered appropriate n (%) | |
| Yes | 263 (77.4%) |
| No | 67 (19.7%) |
| Not recorded | 10 (2.9%) |
| Proforma Field | Value |
| Number of medicines median (interquartile range) | |
| Prior to review | 9 (6–12) |
| After review | 9 (6–12) |
| Stopped by pharmacist | 0 (0–0) |
| Changes recommended by pharmacists n (%) | 149 (43.8%) |
| Pharmacist categorisation of medicine fall risk as per PrescQIPP n (%) | |
| Yes | 76 (22.2%) |
| High risk | 43 (12.6%) |
| Medium risk | 11 (3.2%) |
| Possible risk | 13 (3.8%) |
| Risk present but level not recorded | 9 (2.6%) |
| No | 51 (15.0%) |
| Not recorded | 213 (62.6%) |
| Survey Question | Result |
| Age mean (standard deviation) | 83.59 (9.99) |
| Gender n (%) | |
| Male | 26 (54.2%) |
| Female | 21 (43.8%) |
| N/A | 1 (2.1%) |
| Ethnic group n (%) | |
| Asian/Asian British Indian | 1 (2.1%) |
| White British | 44 (91.7%) |
| White Irish | 2 (4.2%) |
| N/A | 1 (2.1%) |
| How many medicines were you taking? n (%) | |
| 0 | 1 (2.1%) |
| 1 to 4 | 14 (29.2%) |
| 5 or more | 30 (62.5%) |
| Don’t know | 1 (2.1%) |
| N/A | 2 (4.2%) |
| How was your medicines review undertaken? n (%) | |
| Face-to-face | 15 (31.2%) |
| Telephone | 13 (27.1%) |
| Don’t know | 14 (29.2%) |
| N/A | 6 (12.5%) |
| Reported emotion before review (n) | Reported emotion after review (n) | ||
| Negative | Neutral | Positive | |
| Negative | 2 | 3 | 4 |
| Neutral | 0 | 23 | 0 |
| Positive | 0 | 1 | 5 |
| Question |
Overall n (%) |
Referred n (%) |
Not referred n (%) |
| Total responses | 146 (100%) | 18 (12.3%) | 128 (87.7%) |
| Respondent role | |||
| Advanced Paramedic | 7 (4.8%) | 0 (0%) | 7 (5.5%) |
| Emergency Care Assistant | 21 (14.4%) | 1 (5.6%) | 20 (15.6%) |
| Emergency Medical Technician | 9 (6.2%) | 3 (16.7%) | 6 (4.7%) |
| Manager | 13 (8.9%) | 1 (5.6%) | 12 (9.4%) |
| Newly Qualified Paramedic | 21 (14.4%) | 1 (5.6%) | 20 (15.6%) |
| Paramedic | 65 (44.5%) | 11 (61.1%) | 54 (42.2%) |
| Specialist Paramedic | 6 (4.1%) | 1 (5.6%) | 5 (3.9%) |
| Student Paramedic | 4 (2.7%) | 0 (0%) | 4 (3.1%) |
| Working arrangement | |||
| Full-time (37.5 hours a week) | 112 (76.7%) | 16 (88.9%) | 96 (75.0%) |
| Part-time (including bank) | 34 (23.3%) | 2 (11.1%) | 32 (25.0%) |
| How frequently do you attend an incident involving a patient over the age 65 years who has fallen, on average? | |||
| More than once a shift | 55 (37.7%) | 8 (44.4%) | 47 (36.7%) |
| Once a shift | 63 (43.2%) | 8 (44.4%) | 55 (43.0%) |
| Once a week | 12 (8.2%) | 1 (5.6%) | 11 (8.6%) |
| Once a month | 16 (11.0%) | 1 (5.6%) | 15 (11.7%) |
| Have you or your crewmate referred a patient to a pharmacist for a community medicine review? | |||
| Yes | 18 (12.3%) | 18 (100%) | 0 (0%) |
| No, and work in the study area | 22 (15.1%) | 0 (0%) | 22 (17.2%) |
| No, but do not work in the study area | 102 (69.9%) | 0 (0%) | 102 (79.7%) |
| Unsure | 4 (2.7%) | 0 (0%) | 4 (3.1%) |
| How important do you feel it is to have the option to refer patients who have fallen and who are taking multiple medicines, to a community pharmacist for review? | |||
| Very important | 79 (54.1%) | 12 (66.7%) | 67 (52.3%) |
| Important | 46 (31.5%) | 4 (22.2%) | 42 (32.8%) |
| Neutral | 16 (11.0%) | 1 (5.6%) | 15 (11.7%) |
| Unimportant | 2 (1.4%) | 0 (0%) | 2 (1.6%) |
| Very unimportant | 1 (0.7%) | 0 (0%) | 1 (0.8%) |
| N/A | 2 (1.4%) | 1 (5.6%) | 1 (0.8%) |
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