Submitted:
22 May 2025
Posted:
22 May 2025
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Abstract
Keywords:
1. Introduction
1.1. Health Care Access Barriers (HCAB) Model as a Theoretical Framework
- I.
- Structural barriers, which involve logistical challenges such as transportation obstacles, clinic operating hours, and provider availability. These factors significantly impact access to maternal healthcare services, particularly in resource-limited settings [15].
- II.
- Financial barriers, which encompass affordability issues, including the cost of care, insurance access, and out-of-pocket expenses. Economic constraints often dictate whether individuals can seek essential prenatal and perinatal services [16].
- III.
- Cognitive barriers, which relate to individual-level determinants such as pregnancy awareness, cultural beliefs, health literacy, and perceptions of healthcare accessibility. These elements shape care-seeking behaviors and can contribute to disparities in maternal health [14].
1.2. Rationale for Mediation and Moderation
1.3. Latent Class Analysis of Barriers
1.4. Study Aims and Hypotheses
- Identify latent barrier profiles using Alabama's PRAMS Phase 8 barrier items.
- Examine the association between pregnancy intentionality (planned vs. unplanned) and early prenatal care initiation.
- Evaluate whether barrier profiles mediate and/or moderate the relationship between intentionality and early prenatal care.
- Integrate qualitative insights from expert interviews to contextualize and validate quantitative findings.
- H1 (Mediation): Women with unplanned pregnancies are more likely to belong to high-barrier latent profiles, which may subsequently reduce their odds of early prenatal care initiation. If mediation is present, reducing these barriers should alter the causal pathway between pregnancy intentionality and care access.
- H2 (Moderation): Even among women with planned pregnancies, early prenatal care initiation is less likely for those classified into high-barrier profiles. This suggests that pregnancy intentionality alone cannot ensure access, highlighting the need for targeted interventions to address structural and financial barriers.
- H3 (Descriptive): Expert interviews will provide critical insights into how structural, financial, and cognitive barriers manifest in Alabama’s maternal healthcare system, complementing the quantitative classifications.
2. Methods
2.1. Study Design
2.2. Data Source and Sample
2.3. Study Variables and Measures
- I.
- Pregnancy Intentionality: This was categorized as planned or unplanned based on responses to PRAMS Phase 8 question 12 (Qn12).
- II.
- Early Prenatal Care Initiation: This was evaluated dichotomously as receiving prenatal care as early as desired (Yes/No), based on PRAMS Phase 8 question 20 (Qn20).
- I.
- Structural Barriers: This captures barriers relating to transportation, appointment availability, and clinic operational hours.
- II.
- Financial Barriers: This captures barriers relating to insurance status, cost, and affordability issues.
- III.
- Cognitive Barriers: This captures barriers relating to pregnancy recognition, perceived importance of care, cultural beliefs, and health literacy.
2.4. Statistical Analysis
3. Results
3.1. Sample Characteristics
3.2. Latent Class Analysis
3.3. Firth-Penalized Multivariable Logistic Regression
3.4. Mediation Analysis
3.5. Qualitative Findings from Expert Interviews
4. Discussion
4.1. Summary of Key Findings
4.2. Understanding Barriers Beyond the Numbers
4.3. Implications for Policy and Practice
4.4. Study Limitations
5. Conclusion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
References
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| Variable | Operational Definition | Coding/Measurement | Data Source |
| Pregnancy Intentionality | Whether the pregnancy was planned or unplanned | Planned (0), Unplanned (1) | ADPH PRAMS Phase 8; 2016–2021; Qn# 12 |
| Early Prenatal Care | Whether care was received as early as desired | Yes (1), No (0) | ADPH PRAMS Phase 8; 2016–2021; Qn# 20 |
| Structural Barriers | Barriers such as transportation, appointment delays, or clinic logistics | Latent class profile from LCA | ADPH PRAMS Phase 8; 2016–2021; Qn# 21 |
| Financial Barriers | Barriers related to insurance, cost, and affordability | Latent class profile from LCA | ADPH PRAMS Phase 8; 2016–2021; Qn# 21 |
| Cognitive Barriers | Barriers involving awareness, beliefs, and knowledge about prenatal care | Latent class profile from LCA | ADPH PRAMS Phase 8; 2016–2021; Qn# 21 |
| Maternal Age | Age of respondent at time of birth | Categorical: 15–19 to 40+ | ADPH PRAMS Phase 8; 2016–2021; Respondent Characteristics |
| BMI | Body Mass Index category based on pre-pregnancy weight | Underweight (n = 153), Healthy (n = 1,710), Overweight (n = 1,050), Obese (n = 1,325) | ADPH PRAMS Phase 8; 2016–2021; Respondent Characteristics |
| Race/Ethnicity | Self-identified racial or ethnic group | Hispanic (1), Non-Hispanic Black (2), Non-Hispanic White (3) | ADPH PRAMS Phase 8; 2016–2021; Respondent Characteristics |
| Insurance Status | Type of insurance coverage reported by respondent | Categorical: e.g., Job, Medicaid, Uninsured | ADPH PRAMS Phase 8; 2016–2021; Qn# 9, #10, #11 |
| Household Income | Total reported household income | 12 bracketed categories | ADPH PRAMS Phase 8; 2016–2021; Qn# 79 |
| Variable | Category | n (%) |
| Pregnancy Intentionality | Planned | 277 (46.5%) |
| Unplanned | 319 (53.5%) | |
| Early Prenatal Care | Yes | 403 (67.6%) |
| No | 193 (32.4%) | |
| Race/Ethnicity | Non-Hispanic White | 333 (55.9%) |
| Non-Hispanic Black | 200 (33.5%) | |
| Hispanic Origin | 63 (10.6%) | |
| Body Mass Index (BMI) | Healthy Weight | 251 (42.1%) |
| Obesity Weight | 199 (33.4%) | |
| Overweight Weight | 134 (22.5%) | |
| Underweight Weight | 12 (2.0%) | |
| Annual Household Income | Low (<$25K) | 249 (41.8%) |
| Middle ($25K–$60K) | 171 (28.7%) | |
| High ($60K+) | 176 (29.5%) | |
| Maternal Age | 15–19 | 38 (6.4%) |
| 20–24 | 153 (25.7%) | |
| 25–29 | 183 (30.7%) | |
| 30–34 | 147 (24.7%) | |
| 35 or older | 75 (12.6%) |
| Number of Classes | AIC |
BIC |
| 2 |
5940.01 | 6040.71 |
| 3 |
5947.22 | 6100.47 |
| 4 |
5955.74 | 6161.52 |
| Predictor | Odds Ratio | SE | z-value | p | 95% CI |
| Main effects | |||||
| latent class 2 (vs. Class 1) | 0.287 | 1.453 | −0.86 | .315 | [0.002, 2.514] |
| PregnancyIntent Unplanned (vs. planned) | 0.779 | 0.231 | −1.08 | .286 | [0.490, 1.232] |
| Covariates | |||||
| Age 20–24 | 0.733 | 0.390 | −0.80 | .429 | [0.333, 1.585] |
| Age 25–29 | 0.674 | 0.389 | −1.01 | .313 | [0.307, 1.452] |
| Age 30–34 | 1.289 | 0.366 | 0.69 | .492 | [0.624, 2.679] |
| Age 35–39 | 1.152 | 0.365 | 0.39 | .701 | [0.557, 2.395] |
| Age 40 or older | 0.552 | 0.425 | −1.40 | .161 | [0.229, 1.262] |
| Race Non-Hispanic Black | 0.707 | 0.285 | −1.22 | .229 | [0.396, 1.243] |
| Race Non-Hispanic White | 0.981 | 0.270 | −0.07 | .943 | [0.571, 1.681] |
| BMI Obesity Weight | 0.986 | 0.323 | −0.04 | .965 | [0.516, 1.875] |
| BMI Overweight Weight | 0.897 | 0.316 | −0.35 | .732 | [0.476, 1.681] |
| BMI Underweight Weight | 0.879 | 0.315 | −0.41 | .687 | [0.467, 1.649] |
| Interaction | |||||
| latent class 2 × PregnancyIntent Unplanned | 5.185 | 1.714 | 0.96 | .309 | [0.222, 828.944] |
|
Path |
B | SE | β | z | p |
| a₁. Personal barriers ← Unplanned pregnancy |
0.035 | 0.121 | .018 | 0.29 | .769 |
| a₂. Structural barriers ← Unplanned pregnancy |
0.010 | 0.214 | .005 | 0.05 | .962 |
| b₁. Early care ← Personal barriers |
–0.199 | 0.086 | –.199 | –2.31 | .021* |
| b₂. Early care ← Structural barriers |
0.242 | 0.142 | .241 | 1.70 | .089† |
| c′. Early care ← Unplanned pregnancy |
–0.111 | 0.136 | –.055 | –0.81 | .416 |
| Indirect via personal barriers (a₁×b₁) |
–0.007 | 0.024 | –.004 | –0.29 | .771 |
| Indirect via structural barriers (a₂×b₂) |
0.002 | 0.052 | .001 | 0.05 | .962 |
| Total indirect (sum of both) |
–0.005 | 0.064 | –.002 | –0.07 | .943 |
| Total effect (c′ + total indirect) | –0.115 | 0.126 | –.058 | –0.91 | .361 |
|
Interview Question |
HCAB Domain (s) |
| 1. What do you see as the biggest structural barriers to early prenatal care in Alabama? | Structural |
| 2. In your experience, how do financial constraints affect women’s access to timely prenatal care? | Financial |
| 3. How do knowledge, awareness, or cultural beliefs shape decisions around seeking early prenatal care? | Cognitive |
| 4. What are your observations on provider -patient communication, particularly in early pregnancy | Cognitive |
| 5. How does social support, or the lack of it, affect care-seeking behavior? | Structural |
| 6. From your experience, how do limitations in care coordination, clinic infrastructure, or provider availability affect early prenatal care access? | Structural |
| 7. What kinds of interventions or tools would help pregnant women navigate the system efficiently? | Cognitive, Structural |
| 8. Are there any groups of women, like immigrants, low-income, and rural residents, who face unique access barriers? | Structural, Financial, Cognitive |
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