Submitted:
11 February 2025
Posted:
12 February 2025
You are already at the latest version
Abstract
Keywords:
1. Introduction
1.1. Luxembourg: A Small Multilingual and Multicultural Country
1.2. Machine Learning Techniques Applied to Pregnancy and Childbirth
2. Materials and Methods
2.1. Data Collection
2.1.1. The Online Survey
2.1.2. The Participants
2.1.3. The Questions
2.1.4. The Data
2.2. Statistical Analysis
2.3. Machine Learning Models
3. Results of Statistical Analysis
3.1. Exploratory Data Analysis
3.2. Generalized Linear Modeling to Assess Factors Influencing CS
3.3. Insights into the Happiness and Respect Experienced by Women Through GLM
3.4. ANOVA
3.5. MANOVA
4. Results of Machine Learning Models to Predict CS
4.1. Cross-Validations Results for Models Trained on Non-Augmented Data
4.2. Cross-Validations Results for Models Trained on Augmented Data
| Fold | Train Accuracy | Train Precision | Train Recall | Train F1 Score | Test Accuracy | Test Precision | Test Recall | Test F1 Score |
|---|---|---|---|---|---|---|---|---|
| 1 | 82.9 | 81.0 | 86.3 | 83.5 | 85.1 | 78.6 | 94.3 | 85.7 |
| 2 | 84.8 | 83.9 | 87.1 | 85.5 | 75.7 | 63.2 | 85.7 | 72.7 |
| 3 | 83.5 | 83.8 | 83.3 | 83.6 | 79.7 | 78.8 | 76.5 | 77.6 |
| 4 | 83.2 | 82.2 | 85.2 | 83.7 | 79.7 | 71.4 | 90.9 | 80.0 |
| 5 | 82.7 | 81.8 | 84.0 | 82.9 | 85.1 | 86.8 | 84.6 | 85.7 |
| 6 | 84.5 | 83.3 | 86.1 | 84.6 | 73.0 | 75.0 | 75.0 | 75.0 |
| 7 | 84.5 | 83.5 | 85.3 | 84.4 | 77.0 | 84.6 | 75.0 | 79.5 |
| 8 | 85.4 | 84.6 | 85.9 | 85.3 | 75.7 | 77.8 | 81.4 | 79.5 |
| 9 | 83.9 | 82.7 | 85.5 | 84.1 | 77.0 | 82.9 | 72.5 | 77.3 |
| 10 | 84.2 | 84.5 | 84.2 | 84.4 | 85.1 | 82.9 | 85.3 | 84.1 |
| Mean | 84.0 | 83.1 | 85.3 | 84.2 | 79.3 | 78.2 | 82.1 | 79.7 |
4.3. Confusion Matrix
4.4. Comparison of Classification Models
5. Discussion
6. Conclusions
Author Contributions
Funding
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
| CS | Ceasarean Section(s) |
| GLM | Generalized Linear Modeling |
| ML | Machine Learning |
| ANOVA | Analysis of Variance |
| MANOVA | Multivariate Analysis of Variance |
| EDA | Exploratory Data Analysis |
| AdaBoost | Adaptive Boosting |
| CatBoost | Categorical Boosting |
| XGBoost | Gradient Boosting |
| SMOTE | Synthetic Minority Over-sampling Technique |
| AIC | Akaike information criterion |
Appendix A. Statistical Analysis Results
Appendix A.1. GLM Results
| Variable | Estimate () | Std. Error | z value | p-value |
|---|---|---|---|---|
| Intercept | 15.6744 | 646.6176 | 0.024 | 0.9807 |
| French Language | -0.7622 | 0.3249 | -2.346 | 0.0190* |
| German Language | -0.0975 | 0.4754 | -0.205 | 0.8375 |
| Luxembourgish Language | 0.2274 | 0.5265 | 0.432 | 0.6657 |
| English Language | -0.4948 | 0.4697 | -1.053 | 0.2921 |
| Portuguese Language | 0.5387 | 0.6004 | 0.897 | 0.3695 |
| Spanish Language | -0.1102 | 0.3649 | -0.302 | 0.7627 |
| Other Language | 0.1941 | 0.3085 | 0.629 | 0.5292 |
| Hospital:A | -14.9427 | 646.6178 | -0.023 | 0.9816 |
| Hospital:B | -14.0180 | 646.6173 | -0.022 | 0.9827 |
| Hospital:C | -13.5856 | 646.6173 | -0.021 | 0.9832 |
| Induction | -0.6319 | 0.2942 | -2.148 | 0.0317* |
| Health Conditions | -0.4018 | 0.3358 | -1.196 | 0.2316 |
| First Birth | -0.1558 | 0.3522 | -0.442 | 0.6582 |
| Vaginal Birth | 1.3403 | 0.2949 | 4.545 | 5.51e-06*** |
| Variable | Estimate () | Std. Error | z value | p-value |
|---|---|---|---|---|
| Intercept | 2.982381 | 0.823321 | 3.622 | 0.000292*** |
| Hospital:A | 0.015405 | 0.995280 | 0.015 | 0.987651 |
| Hospital:B | 0.536672 | 0.754019 | 0.712 | 0.476621 |
| Hospital:C | 0.641373 | 0.768241 | 0.835 | 0.403797 |
| Induction | -0.246522 | 0.307101 | -0.803 | 0.422126 |
| Health Conditions | -0.522239 | 0.303347 | -1.722 | 0.085144. |
| First Birth | -0.120879 | 0.353763 | -0.342 | 0.732580 |
| Previous CS | -0.006011 | 0.573796 | -0.010 | 0.991641 |
| Intervention Rupture | 0.249053 | 0.319325 | 0.780 | 0.435430 |
| Intervention Oxytocin | -0.948630 | 0.366793 | -2.586 | 0.009702** |
| Intervention Episiotomy | -0.299293 | 0.379828 | -0.788 | 0.430715 |
| Intervention Instruments | -0.846831 | 0.339283 | -2.496 | 0.012562* |
| Intervention Kristeller | -0.707243 | 0.389488 | -1.816 | 0.069397. |
| No Intervention | -0.530143 | 0.463651 | -1.143 | 0.252869 |
| Other Intervention | -2.442600 | 0.449521 | -5.434 | 5.52e-08*** |
| Epidural | -0.724259 | 0.364169 | -1.989 | 0.046724* |
| Variable | Estimate () | Std. Error | z value | p-value |
|---|---|---|---|---|
| Intercept | 2.00577 | 0.84679 | 2.369 | 0.0179* |
| French Language | -0.32518 | 0.27913 | -1.165 | 0.2440 |
| German Language | -0.51867 | 0.36105 | -1.437 | 0.1508 |
| Luxembourgish Language | 0.01419 | 0.39582 | 0.036 | 0.9714 |
| English Language | -0.07646 | 0.38157 | -0.200 | 0.8412 |
| Portuguese Language | 0.27575 | 0.49050 | 0.562 | 0.5740 |
| Spanish Language | -0.56531 | 0.30265 | -1.868 | 0.0618 . |
| Other Languages | 0.03390 | 0.26492 | 0.128 | 0.8982 |
| Hospital:A | -0.51976 | 0.91661 | -0.567 | 0.5707 |
| Hospital:B | 0.25821 | 0.70181 | 0.368 | 0.7129 |
| Hospital:C | 0.56705 | 0.71462 | 0.794 | 0.4275 |
| Induction | -0.34561 | 0.25800 | -1.340 | 0.1804 |
| Health Conditions | -0.33844 | 0.29103 | -1.163 | 0.2449 |
| First Birth | -0.41515 | 0.28681 | -1.447 | 0.1478 |
| Vaginal Birth | 0.63235 | 0.26784 | 2.361 | 0.0182* |
| Epidural | -0.30580 | 0.29591 | -1.033 | 0.3014 |
| Variable | Estimate () | Std. Error | z value | p-value |
|---|---|---|---|---|
| Intercept | 2.7043 | 0.7937 | 3.407 | 0.000656*** |
| Hospital:A | -0.0818 | 0.9533 | -0.086 | 0.932 |
| Hospital:B | 0.4717 | 0.7287 | 0.647 | 0.517 |
| Hospital:C | 0.5999 | 0.7449 | 0.805 | 0.421 |
| Induction | 0.2091 | 0.3112 | 0.672 | 0.502 |
| Health Conditions | -0.2718 | 0.3049 | -0.892 | 0.373 |
| First Birth | -0.3560 | 0.3461 | -1.029 | 0.304 |
| Previous CS | -0.5655 | 0.5431 | -1.041 | 0.298 |
| Intervention Rupture | -0.1818 | 0.3118 | -0.583 | 0.560 |
| Intervention Oxytocin | -1.1210 | 0.3690 | -3.038 | 0.002** |
| Intervention Episiotomy | -0.7170 | 0.3593 | -1.996 | 0.046* |
| Intervention Instrumental | -0.2561 | w0.3454 | -0.741 | 0.458 |
| Intervention Kristeller | -0.9817 | 0.3837 | -2.559 | 0.011* |
| No Intervention | -0.6916 | 0.4385 | -1.577 | 0.115 |
| Other Interventions | -1.8580 | 0.4268 | -4.353 | 1.34e-05*** |
| Epidural | -0.1438 | 0.3229 | -0.445 | 0.656 |
Appendix A.2. ANOVA Results
| Variable | Df | Sum Sq | Mean Sq | F-value | p-value |
|---|---|---|---|---|---|
| French Language | 1 | 0.43 | 0.428 | 2.495 | 0.1149 |
| German Language | 1 | 0.90 | 0.901 | 5.252 | 0.0223* |
| Luxembourgish Language | 1 | 0.01 | 0.005 | 0.032 | 0.8588 |
| English Language | 1 | 0.00 | 0.004 | 0.021 | 0.8859 |
| Portuguese Language | 1 | 0.00 | 0.002 | 0.012 | 0.9118 |
| Spanish Language | 1 | 1.31 | 1.311 | 7.644 | 0.0059** |
| Other Languages | 1 | 0.51 | 0.510 | 2.975 | 0.0852 |
| Hospital | 3 | 1.13 | 0.376 | 2.192 | 0.0882 |
| Induction | 1 | 0.48 | 0.480 | 2.800 | 0.0949 |
| Health Conditions | 1 | 2.21 | 2.211 | 12.890 | 0.0004*** |
| First Birth | 1 | 1.66 | 1.662 | 9.693 | 0.0020** |
| Previous CS | 1 | 4.87 | 4.874 | 28.418 | 1.5e-07*** |
| Age | 1 | 0.51 | 0.514 | 2.999 | 0.0839 |
| Epidural | 1 | 0.08 | 0.079 | 0.459 | 0.4985 |
| Residuals | 485 | 83.18 | 0.172 |
Appendix B
| Variable | Df | Sum Sq | Mean Sq | F-value | p-value |
|---|---|---|---|---|---|
| Hospital | 3 | 1.19 | 0.397 | 2.805 | 0.0393* |
| Induction | 1 | 0.60 | 0.602 | 4.255 | 0.0397* |
| Health Conditions | 1 | 2.55 | 2.546 | 17.988 | 2.66e-05*** |
| First Birth | 1 | 1.50 | 1.503 | 10.622 | 0.0012** |
| Previous CS | 1 | 5.19 | 5.187 | 36.649 | 2.83e-09*** |
| Interventions Rupture | 1 | 2.65 | 2.647 | 18.700 | 1.86e-05*** |
| Interventions Oxytocin | 1 | 0.58 | 0.578 | 4.081 | 0.0439* |
| Interventions Episiotomy | 1 | 4.05 | 4.052 | 28.626 | 1.35e-07*** |
| Interventions Instruments | 1 | 3.94 | 3.938 | 27.821 | 2.01e-07*** |
| Interventions Kristeller | 1 | 0.99 | 0.986 | 6.968 | 0.0086** |
| Interventions None | 1 | 0.05 | 0.053 | 0.372 | 0.5423 |
| Interventions Other | 1 | 3.51 | 3.510 | 24.803 | 8.84e-07*** |
| Epidural | 1 | 1.71 | 1.714 | 12.109 | 0.0005*** |
| Residuals | 486 | 68.78 | 0.142 |
Appendix C. ML Model Metrics for Non-Augmented Data
| Fold | Train Accuracy | Train Precision | Train Recall | Train F1 Score | Test Accuracy | Test Precision | Test Recall | Test F1 Score |
|---|---|---|---|---|---|---|---|---|
| 1 | 84.0 | 79.5 | 52.5 | 63.3 | 76.5 | 58.3 | 50.0 | 53.8 |
| 2 | 83.1 | 76.9 | 50.8 | 61.2 | 78.4 | 71.4 | 35.7 | 47.6 |
| 3 | 82.7 | 75.3 | 51.3 | 61.0 | 78.0 | 66.7 | 30.8 | 42.1 |
| 4 | 84.1 | 78.3 | 54.6 | 64.4 | 70.0 | 37.5 | 23.1 | 28.6 |
| 5 | 82.5 | 76.3 | 48.7 | 59.5 | 84.0 | 77.8 | 53.8 | 63.6 |
| 6 | 81.9 | 75.3 | 46.2 | 57.3 | 90.0 | 100.0 | 61.5 | 76.2 |
| 7 | 82.7 | 74.7 | 52.1 | 61.4 | 80.0 | 80.0 | 30.8 | 44.4 |
| 8 | 83.6 | 77.8 | 52.9 | 63.0 | 78.0 | 75.0 | 23.1 | 35.3 |
| 9 | 81.4 | 73.3 | 46.2 | 56.7 | 94.0 | 85.7 | 92.3 | 88.9 |
| 10 | 83.2 | 74.7 | 54.6 | 63.1 | 76.0 | 54.5 | 46.2 | 50.0 |
| Mean | 82.9 | 76.2 | 51.0 | 61.1 | 80.5 | 70.7 | 44.7 | 53.0 |
| Fold | Train Accuracy | Train Precision | Train Recall | Train F1 Score | Test Accuracy | Test Precision | Test Recall | Test F1 Score |
|---|---|---|---|---|---|---|---|---|
| 1 | 84.5 | 75.0 | 61.0 | 67.3 | 70.6 | 46.7 | 50.0 | 48.3 |
| 2 | 83.4 | 74.2 | 55.9 | 63.8 | 82.4 | 72.7 | 57.1 | 64.0 |
| 3 | 82.7 | 72.0 | 56.3 | 63.2 | 82.0 | 75.0 | 46.2 | 57.1 |
| 4 | 82.7 | 73.0 | 54.6 | 62.5 | 72.0 | 45.5 | 38.5 | 41.7 |
| 5 | 81.9 | 71.3 | 52.1 | 60.2 | 88.0 | 81.8 | 69.2 | 75.0 |
| 6 | 81.6 | 69.6 | 53.8 | 60.7 | 86.0 | 87.5 | 53.8 | 66.7 |
| 7 | 83.6 | 75.9 | 55.5 | 64.1 | 82.0 | 75.0 | 46.2 | 57.1 |
| 8 | 82.7 | 72.0 | 56.3 | 63.2 | 72.0 | 42.9 | 23.1 | 30.0 |
| 9 | 81.4 | 70.6 | 50.4 | 58.8 | 90.0 | 83.3 | 76.9 | 80.0 |
| 10 | 84.1 | 75.3 | 58.8 | 66.0 | 74.0 | 50.0 | 53.8 | 51.9 |
| Mean | 82.9 | 72.9 | 55.5 | 63.0 | 79.9 | 66.0 | 51.5 | 57.2 |
| Fold | Train Accuracy | Train Precision | Train Recall | Train F1 Score | Test Accuracy | Test Precision | Test Recall | Test F1 Score |
|---|---|---|---|---|---|---|---|---|
| 1 | 85.8 | 93.5 | 49.2 | 64.4 | 80.4 | 75.0 | 42.9 | 54.5 |
| 2 | 83.8 | 88.1 | 44.1 | 58.8 | 82.4 | 100.0 | 35.7 | 52.6 |
| 3 | 85.4 | 93.4 | 47.9 | 63.3 | 76.0 | 57.1 | 30.8 | 40.0 |
| 4 | 84.7 | 90.3 | 47.1 | 61.9 | 76.0 | 66.7 | 15.4 | 25.0 |
| 5 | 85.0 | 93.2 | 46.2 | 61.8 | 78.0 | 66.7 | 30.8 | 42.1 |
| 6 | 83.8 | 91.1 | 42.9 | 58.3 | 86.0 | 100.0 | 46.2 | 63.2 |
| 7 | 84.1 | 88.5 | 45.4 | 60.0 | 80.0 | 80.0 | 30.8 | 44.4 |
| 8 | 85.0 | 91.8 | 47.1 | 62.2 | 78.0 | 75.0 | 23.1 | 35.3 |
| 9 | 82.7 | 90.2 | 38.7 | 54.1 | 92.0 | 100.0 | 69.2 | 81.8 |
| 10 | 84.7 | 89.1 | 47.9 | 62.3 | 76.0 | 57.1 | 30.8 | 40.0 |
| Mean | 84.5 | 90.9 | 45.6 | 60.7 | 80.5 | 77.8 | 35.6 | 47.9 |
| Fold | Train Accuracy | Train Precision | Train Recall | Train F1 Score | Test Accuracy | Test Precision | Test Recall | Test F1 Score |
|---|---|---|---|---|---|---|---|---|
| 1 | 85.4 | 88.2 | 50.8 | 64.5 | 76.5 | 62.5 | 35.7 | 45.5 |
| 2 | 85.1 | 87.0 | 50.8 | 64.2 | 78.4 | 71.4 | 35.7 | 47.6 |
| 3 | 85.4 | 89.6 | 50.4 | 64.5 | 82.0 | 75.0 | 46.2 | 57.1 |
| 4 | 85.4 | 86.3 | 52.9 | 65.6 | 74.0 | 50.0 | 15.4 | 23.5 |
| 5 | 85.2 | 88.2 | 50.4 | 64.2 | 78.0 | 66.7 | 30.8 | 42.1 |
| 6 | 83.8 | 82.9 | 48.7 | 61.4 | 86.0 | 100.0 | 46.2 | 63.2 |
| 7 | 85.6 | 89.7 | 51.3 | 65.2 | 80.0 | 80.0 | 30.8 | 44.4 |
| 8 | 85.6 | 88.6 | 52.1 | 65.6 | 76.0 | 60.0 | 23.1 | 33.3 |
| 9 | 83.6 | 88.1 | 43.7 | 58.4 | 88.0 | 81.8 | 69.2 | 75.0 |
| 10 | 84.5 | 86.6 | 48.7 | 62.4 | 78.0 | 58.3 | 53.8 | 56.0 |
| Mean | 85.0 | 87.5 | 50.0 | 63.6 | 79.7 | 70.6 | 38.7 | 48.8 |
Appendix D. Reproducibility: R & Python Packages State
References
- Dahlen, H.; Kennedy, H.; Anderson, C.; Bell, A.; Clark, A.; Foureur, M.; Ohm, J.; Shearman, A.; Taylor, J.; Wright, M.; et al. The EPIIC hypothesis: Intrapartum effects on the neonatal epigenome and consequent health outcomes. Medical Hypotheses 2013, 80, 656–662. [CrossRef]
- Olza-Fernández, I.; Marín Gabriel, M.A.; Gil-Sanchez, A.; Garcia-Segura, L.M.; Arevalo, M.A. Neuroendocrinology of childbirth and mother–child attachment: The basis of an etiopathogenic model of perinatal neurobiological disorders. Frontiers in Neuroendocrinology 2014, 35, 459–472. [CrossRef]
- Wampach, L.; Heintz-Buschart, A.; Fritz, J.V.; Ramiro-Garcia, J.; Habier, J.; Herold, M.; Narayanasamy, S.; Kaysen, A.; Hogan, A.H.; Bindl, L.; et al. Birth mode is associated with earliest strain-conferred gut microbiome functions and immunostimulatory potential. Nature communications 2018, 9, 5091. [CrossRef]
- Baumgartner, T.; Heinrichs, M.; Vonlanthen, A.; Fischbacher, U.; Fehr, E. Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Neuron 2008, 58, 639–650. [CrossRef]
- Bailham, D.; Joseph, S. Post-traumatic stress following childbirth: a review of the emerging literature and directions for research and practice. Psychology, Health & Medicine 2003, 8, 159–168. [CrossRef]
- Green, J.M.; Coupland, V.A.; Kitzinger, J.V. Expectations, experiences, and psychological outcomes of childbirth: a prospective study of 825 women. Birth 1990, 17, 15–24. [CrossRef]
- Simkin, P. Just another day in a woman’s life? Women’s long-term perceptions of their first birth experience. Part I. Birth 1991, 18, 203–210. [CrossRef]
- Sandall, J.; Tribe, R.M.; Avery, L.; Mola, G.; Visser, G.H.; Homer, C.S.; Gibbons, D.; Kelly, N.M.; Kennedy, H.P.; Kidanto, H.; et al. Short-term and long-term effects of caesarean section on the health of women and children. The Lancet 2018, 392, 1349–1357.
- Keag, O.E.; Norman, J.E.; Stock, S.J. Long-term risks and benefits associated with cesarean delivery for mother, baby, and subsequent pregnancies: Systematic review and meta-analysis. PLoS medicine 2018, 15, e1002494. [CrossRef]
- Direction de la Santé, L.I.o.H.L. Surveillance de la Santé Perinatal au Luxembourg 2017-2019, 2023. Accessed: 2024-12-03.
- (SRH), S..R.H..R. WHO statement on Cesarean section rates, 2015. Accessed: 2024-12-03.
- Statec. Luxembourg in figures 2024, 2024. Accessed: 2024-12-03.
- Statec.; Statistiques.lu. Luxembourg census data for linguistic diversity, 2023. Accessed: 2024-12-03.
- Lipschuetz, M.; Guedalia, J.; Rottenstreich, A.; Persky, M.N.; Cohen, S.M.; Kabiri, D.; Levin, G.; Yagel, S.; Unger, R.; Sompolinsky, Y. Prediction of vaginal birth after cesarean deliveries using machine learning. American journal of obstetrics and gynecology 2020, 222, 613–e1. [CrossRef]
- Sana, A.; Razzaq, S.; Ferzund, J. Automated diagnosis and cause analysis of cesarean section using machine learning techniques. International Journal of Machine Learning and Computing 2012, 2, 677. [CrossRef]
- Daoud, N.; O’Campo, P.; Minh, A.; Urquia, M.L.; Dzakpasu, S.; Heaman, M.; Kaczorowski, J.; Levitt, C.; Smylie, J.; Chalmers, B. Patterns of social inequalities across pregnancy and birth outcomes: a comparison of individual and neighborhood socioeconomic measures. BMC pregnancy and childbirth 2014, 14, 1–17. [CrossRef]
- Islam, M.N.; Mustafina, S.N.; Mahmud, T.; Khan, N.I. Machine learning to predict pregnancy outcomes: a systematic review, synthesizing framework and future research agenda. BMC pregnancy and childbirth 2022, 22, 348. [CrossRef]
- Khan, N.I.; Mahmud, T.; Islam, M.N.; Mustafina, S.N. Prediction of cesarean childbirth using ensemble machine learning methods. In Proceedings of the Proceedings of the 22nd international conference on information integration and web-based applications & services, 2020, pp. 331–339. [CrossRef]
- Bertini, A.; Salas, R.; Chabert, S.; Sobrevia, L.; Pardo, F. Using machine learning to predict complications in pregnancy: a systematic review. Frontiers in bioengineering and biotechnology 2022, 9, 780389. [CrossRef]
- Harrell Jr, F.E.; Harrell Jr, M.F.E. Package ‘hmisc’. CRAN2018 2019, 2019, 235–236.
- R Core Team. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria, 2021.
- Dobson, A.J.; Barnett, A.G. An introduction to generalized linear models; Chapman and Hall/CRC, 2018. [CrossRef]
- Cohen, J. Statistical power analysis for the behavioral sciences; routledge, 2013. [CrossRef]
- Field, A.; Field, Z.; Miles, J. Discovering statistics using R 2012.
- Tabachnick, B.; Fidell, L.; Ullman, J. Using multivariate statistics (Vol. 6, pp 497–516), 2019.
- Hosmer Jr, D.W.; Lemeshow, S.; Sturdivant, R.X. Applied logistic regression; John Wiley & Sons, 2013.
- Freund, Y.; Schapire, R.E. A decision-theoretic generalization of on-line learning and an application to boosting. Journal of computer and system sciences 1997, 55, 119–139. [CrossRef]
- Prokhorenkova, L.; Gusev, G.; Vorobev, A.; Dorogush, A.V.; Gulin, A. CatBoost: unbiased boosting with categorical features. Advances in neural information processing systems 2018, 31.
- Chen, T.; Guestrin, C. Xgboost: A scalable tree boosting system. In Proceedings of the Proceedings of the 22nd acm sigkdd international conference on knowledge discovery and data mining, 2016, pp. 785–794. [CrossRef]
- Hastie, T. The elements of statistical learning: data mining, inference, and prediction; Springer, 2009. [CrossRef]
- Chawla, N.V.; Bowyer, K.W.; Hall, L.O.; Kegelmeyer, W.P. SMOTE: synthetic minority over-sampling technique. Journal of artificial intelligence research 2002, 16, 321–357. [CrossRef]
| 1 | |
| 2 |






| Variable | Estimate () | Std. Error | z value | p-value |
|---|---|---|---|---|
| Intercept | -4.84461 | 1.36127 | -3.559 | 0.000372*** |
| French Language | -0.13074 | 0.23412 | -0.558 | 0.576554 |
| German Language | -0.51194 | 0.34197 | -1.497 | 0.134390 |
| Luxembourgish Language | -0.13904 | 0.37880 | -0.367 | 0.713581 |
| English Language | -0.26513 | 0.33405 | -0.794 | 0.427372 |
| Portuguese Language | -0.29681 | 0.43557 | -0.681 | 0.495611 |
| Spanish Language | 0.63515 | 0.28124 | 2.258 | 0.023922 * |
| Other Languages | 0.35197 | 0.24156 | 1.457 | 0.145098 |
| Hospital:A | 0.37351 | 1.15057 | 0.325 | 0.745463 |
| Hospital:B | 0.36358 | 0.83006 | 0.438 | 0.661375 |
| Hospital:C | 0.77114 | 0.83402 | 0.925 | 0.355168 |
| First Birth | 1.68557 | 0.36596 | 4.606 | 4.11e-06*** |
| Previous CS | 2.37856 | 0.48083 | 4.947 | 7.55e-07*** |
| Age | 0.05232 | 0.02803 | 1.867 | 0.061945. |
| Epidural | 0.36932 | 0.26810 | 1.378 | 0.168346 |
| Variable | Estimate () | Std. Error | z value | p-value |
|---|---|---|---|---|
| Intercept | -4.77586 | 1.07034 | -4.462 | 8.12e-06*** |
| Hospital:A | -0.19072 | 1.35345 | -0.141 | 0.887939 |
| Hospital:B | 1.15544 | 0.96434 | 1.198 | 0.230853 |
| Hospital:C | 1.41723 | 0.97417 | 1.455 | 0.145722 |
| Induction | 1.00649 | 0.33367 | 3.016 | 0.002558** |
| Health Conditions | 1.08823 | 0.30988 | 3.512 | 0.000445*** |
| First Birth | 1.90581 | 0.39363 | 4.842 | 1.29e-06*** |
| Previous CS | 2.63249 | 0.54143 | 4.862 | 1.16e-06*** |
| Intervention Rupture | -1.08032 | 0.37620 | -2.872 | 0.004083** |
| Intervention Oxytocin | -0.06261 | 0.41580 | -0.151 | 0.880317 |
| Intervention Episiotomy | -3.34846 | 1.07848 | -3.105 | 0.001904** |
| Intervention Instruments | -1.88462 | 0.48608 | -3.877 | 0.000106*** |
| Intervention Kristeller | -1.48435 | 0.66986 | -2.216 | 0.026698* |
| No Intervention | 0.38150 | 0.47685 | 0.800 | 0.423693 |
| Other Intervention | 2.14909 | 0.51041 | 4.210 | 2.55e-05*** |
| Epidural | 1.00208 | 0.30965 | 3.236 | 0.001212** |
| Variable | Df | Pillai’s Trace | Approx F | num Df | p-value |
|---|---|---|---|---|---|
| French Language | 1 | 0.0093 | 0.6527 | 7 | 0.7122 |
| German Language | 1 | 0.0210 | 1.4948 | 7 | 0.1667 |
| Luxembourgish Language | 1 | 0.0099 | 0.6947 | 7 | 0.6766 |
| English Language | 1 | 0.0174 | 1.2339 | 7 | 0.2823 |
| Portuguese Language | 1 | 0.0249 | 1.7784 | 7 | 0.0895. |
| Spanish Language | 1 | 0.0371 | 2.6860 | 7 | 0.0097** |
| Other Language | 1 | 0.0153 | 1.0868 | 7 | 0.3704 |
| Residuals | 494 |
| Fold | Train Accuracy | Train Precision | Train Recall | Train F1 Score | Test Accuracy | Test Precision | Test Recall | Test F1 Score |
|---|---|---|---|---|---|---|---|---|
| 1 | 81.5 | 80.9 | 82.6 | 81.7 | 79.7 | 77.5 | 83.8 | 80.5 |
| 2 | 81.7 | 81.3 | 82.3 | 81.8 | 83.8 | 85.7 | 81.1 | 83.3 |
| 3 | 80.8 | 80.6 | 81.1 | 80.8 | 81.1 | 82.9 | 78.4 | 80.6 |
| 4 | 81.4 | 81.4 | 81.4 | 81.4 | 78.4 | 78.4 | 78.4 | 78.4 |
| 5 | 80.9 | 80.7 | 81.4 | 81.0 | 77.0 | 76.3 | 78.4 | 77.3 |
| 6 | 79.9 | 79.4 | 80.8 | 80.1 | 89.2 | 91.4 | 86.5 | 88.9 |
| 7 | 81.2 | 81.1 | 81.4 | 81.3 | 75.7 | 74.4 | 78.4 | 76.3 |
| 8 | 80.3 | 80.4 | 80.2 | 80.3 | 82.4 | 81.6 | 83.8 | 82.7 |
| 9 | 80.6 | 80.4 | 81.1 | 80.7 | 81.1 | 78.0 | 86.5 | 82.1 |
| 10 | 82.3 | 82.1 | 82.6 | 82.3 | 67.6 | 66.7 | 70.3 | 68.4 |
| Mean | 81.1 | 80.8 | 81.5 | 81.1 | 79.6 | 79.3 | 80.6 | 79.8 |
| Fold | Train Accuracy | Train Precision | Train Recall | Train F1 Score | Test Accuracy | Test Precision | Test Recall | Test F1 Score |
|---|---|---|---|---|---|---|---|---|
| 1 | 81.8 | 81.5 | 82.3 | 81.9 | 75.7 | 73.2 | 81.1 | 76.9 |
| 2 | 81.2 | 80.6 | 82.3 | 81.4 | 83.8 | 83.8 | 83.8 | 83.8 |
| 3 | 80.3 | 80.1 | 80.8 | 80.4 | 82.4 | 83.3 | 81.1 | 82.2 |
| 4 | 81.8 | 81.9 | 81.7 | 81.8 | 78.4 | 78.4 | 78.4 | 78.4 |
| 5 | 81.5 | 80.9 | 82.6 | 81.7 | 78.4 | 76.9 | 81.1 | 78.9 |
| 6 | 80.9 | 79.4 | 83.5 | 81.4 | 89.2 | 93.9 | 83.8 | 88.6 |
| 7 | 81.7 | 81.9 | 81.4 | 81.6 | 73.0 | 71.8 | 75.7 | 73.7 |
| 8 | 82.3 | 82.3 | 82.3 | 82.3 | 85.1 | 84.2 | 86.5 | 85.3 |
| 9 | 81.7 | 81.3 | 82.3 | 81.8 | 77.0 | 76.3 | 78.4 | 77.3 |
| 10 | 82.3 | 82.7 | 81.7 | 82.2 | 62.2 | 61.5 | 64.9 | 63.2 |
| Mean | 81.6 | 81.3 | 82.1 | 81.6 | 78.5 | 78.3 | 79.5 | 78.8 |
| Fold | Train Accuracy | Train Precision | Train Recall | Train F1 Score | Test Accuracy | Test Precision | Test Recall | Test F1 Score |
|---|---|---|---|---|---|---|---|---|
| 1 | 82.1 | 81.0 | 84.2 | 82.6 | 86.5 | 82.1 | 91.4 | 86.5 |
| 2 | 82.6 | 81.4 | 85.7 | 83.5 | 79.7 | 71.0 | 78.6 | 74.6 |
| 3 | 83.2 | 82.2 | 85.1 | 83.6 | 77.0 | 74.3 | 76.5 | 75.4 |
| 4 | 83.0 | 82.0 | 85.2 | 83.6 | 81.1 | 72.1 | 93.9 | 81.6 |
| 5 | 82.1 | 81.4 | 83.1 | 82.2 | 85.1 | 88.9 | 82.1 | 85.3 |
| 6 | 83.9 | 82.5 | 85.8 | 84.1 | 71.6 | 74.4 | 72.5 | 73.4 |
| 7 | 84.1 | 83.5 | 84.0 | 83.8 | 75.7 | 86.1 | 70.5 | 77.5 |
| 8 | 83.5 | 82.8 | 83.8 | 83.3 | 75.7 | 76.6 | 83.7 | 80.0 |
| 9 | 83.0 | 82.2 | 83.9 | 83.1 | 77.0 | 84.8 | 70.0 | 76.7 |
| 10 | 83.6 | 82.9 | 85.1 | 84.0 | 82.4 | 78.4 | 85.3 | 81.7 |
| Mean | 83.1 | 82.2 | 84.6 | 83.4 | 79.2 | 78.9 | 80.4 | 79.3 |
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).