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Modelling Lifetime Data and Athletes Red Cells Counts Using the New Topp-Leone-Lomax Poisson Distribution

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09 October 2024

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11 October 2024

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Abstract
A new compounded distribution called the Topp-Leone-Lomax Poisson is developed. The statistical properties of this model are derived. The model parameters are estimated via the maximum likelihood technique. The performance of the estimation techniques was assessed by means of simulation studies. The new model was exposed to three data sets and compared to other models within the same class and the evidence supports the importance of the new model in data modelling.
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1. Introduction

Over the past two centuries, statistical distributions gained appreciation from many researchers as a means of describing data. A number of distributions were developed and these include the exponential distribution which was a very important lifetime distribution. This distribution was good in modelling lifetime data with constant failure rate. However, the distribution could not accommodate other failure rates that include decreasing, increasing and non-monotone. Lomax developed the shifted Pareto (Pareto II) or Lomax distribution [9] which is a mixture of the exponential and gamma distributions. This distribution applies to data with decreasing failure rate and has heavier tails compared to the Weibull [19] and gamma distributions. Statisticians came with solutions to address the short comings of classical distributions. These solutions include transformation of the classical distribution for example the T-X transformation by Alzaatreh et al. [4], gamma transformations by Zografos and Balakrishnan [20], Ristiç and Balakrishnan [15], and Torabi and Montazari [18], half logistic transformation by Cordeiro et al. [7], to mention a few. The other techniques for generalizing classical distribution includes exponentiation, power transformation, competing risks, and compounding methods.
Some generalizations of the Lomax distribution include the exponentiated Lomax (Exp-Lx) by Abdul-Moniem and Abdel-Hammed [2], exponential Lomax (E-Lx) by Bassiouny et al. [5], and the Weibull-Lomax (W-Lx) by Tahir et al. [17]. Oguntunde et al. [13] developed the Topp-Leone Lomax (TL-Lx) distribution using the generalization by Al-Shomrani et al. [3]. The TL-Lx distribution is a has a pdf that is skewed to the right. The TL-Lx distribution has cumulative distribution function (cdf) and probability density function (pdf) given by
G ( x ; α , b , λ ) = [ 1 ( 1 + λ x ) 2 b ] α
and
g ( x ; α , b , λ ) = 2 α b λ ( 1 + λ x ) ( 2 b + 1 ) [ 1 ( 1 + λ x ) 2 b ] α 1 ,
respectively, for α , b , λ > 0 . Other generalizations that involves the Topp-Leone generalization include the Topp-Leone odd exponential half logistic-G family of distributions by Chipepa and Oluyede [6], The Topp-Leone-Harris-G family of distributions with applications by Oluyede et al. [12], and the Topp-Leone odd Burr III-G family of distributions by Moakofi et al. [11].
This research generalizes the TL-LxP distribution by compounding it with the power series distribution. Power series distributions includes the Poisson, logarithmic, binomial, and geometric distributions as stated by Johnson et al. [8]. The Poisson distribution is considered as a special case from the power series distributions. Given a discrete random variable, say, M, having a power series distribution with probability mass function (pmf)
P ( M = m ) = a m θ m C ( θ ) , m = 1 , 2 , . . . ,
where C ( θ ) = m = 1 a m θ m is finite, θ > 0 and { a m } m 1 a sequence of positive real numbers. Taking X ( 1 ) = min ( X 1 , X 2 , . . . , X M ) , the cumulative distribution function (cdf) and probability density function (pdf) of X ( 1 ) | M = m are defined by
F X ( 1 ) | M = m ( x ) = 1 C ( θ S ( x ) ) C ( θ ) ,
and
f X ( 1 ) | M = m ( x ) = θ g ( x ) C ( θ S ( x ) ) C ( θ ) ,
where S ( x ) is the survival function given by 1 F ( x ) .
The rest of the paper is organized as follows: Statistical properties are presented in Section 2. Maximum likelihood estimation technique is presented in Section 3. Simulation study and inference are presented in Section 4 and 5, followed by conclusion in Section 6.

2. The Model

In this paper, the TL-Lx distribution by Oguntunde et al. [13] is compounded with the Poisson power series distribution to produce a new model called the Topp-Leone-Lomax Poisson (TL-LxP) distribution. The pdf and the cdf of the TL-LxP distribution is given by
F ( x ; α , b , λ , θ ) = 1 exp θ ( 1 [ 1 ( 1 + λ x ) 2 b ] α ) 1 [ exp ( θ ) 1 ] ,
and
f ( x ; α , b , λ , θ ) = 2 α b λ θ ( 1 + λ x ) ( 2 b + 1 ) [ 1 ( 1 + λ x ) 2 b ] α 1 exp ( θ ) 1 × exp θ ( 1 [ 1 ( 1 + λ x ) 2 b ] α ) ,
for α , b , λ , θ > 0 . The corresponding hazard rate function is given by
h ( x ; α , b , λ , θ ) = 2 α b λ θ ( 1 + λ x ) ( 2 b + 1 ) [ 1 ( 1 + λ x ) 2 b ] α 1 exp θ ( 1 [ 1 ( 1 + λ x ) 2 b ] α ) 1 × exp θ ( 1 [ 1 ( 1 + λ x ) 2 b ] α ) .
The pdf of the TL-LxP takes reverse-J shape, right or left-skewed shapes as shown in Figure 1.

3. Some Statistical Properties

We present in this section quantile function, moments, moment generation function, and Rényi Entropy.

3.1. Quantile Function

The u t h quantile function is defined by F ( x ) = u , 0 < x < 1 . That is
1 exp θ ( 1 [ 1 ( 1 + λ x ) 2 b ] α ) 1 [ exp ( θ ) 1 ] = u
which simplifies to
x = 1 λ 1 θ ln [ 1 + ( 1 u ) ( e θ 1 ) ] θ 1 α 1 2 b 1
The first, second and third quantiles for the TL-LxP distribution are obtained by substituting in equation (9) u = 0.25 , 0.5 a n d 0.75 , respectively. Table 1 show quantile values for the TL-LxP distribution for selected parameter values ( α , b , λ , a n d θ ).

3.2. Moments and Moment Generating Function

The r t h raw moment ( μ r ) of the TL-LxP distribution is given by
μ r = E ( X r ) = x r f ( x ; α , b , λ , θ ) d x ,
with f ( x ; α , b , λ , θ ) defined in Equation (7). Using the generalized binomial series expansion ( 1 z ) a = j = 0 ( 1 ) j a j z j , we have
E ( X r ) = i , j = 0 i j ( 1 ) j 2 α b λ θ i + 1 ( e θ 1 ) i ! 0 x r ( 1 + λ x ) ( 2 b + 1 ) [ 1 ( 1 + λ x ) 2 b ] α + j 1 d x .
Let u = 1 + λ x , implying x = 1 λ ( u 1 ) and d u = λ d x , we get
1 x r ( 1 + λ x ) ( 2 b + 1 ) [ 1 ( 1 + λ x ) 2 b ] α + j 1 d x = m = 0 ( 1 ) m α + j 1 m × 1 1 λ r + 1 ( u 1 ) r u 2 m b 2 b 1 d u .
Thus,
1 1 λ r + 1 ( u 1 ) r u 2 m b 2 b 1 d u = 0 ( u 1 ) ( r + 1 ) 1 λ r + 1 u 2 m b + 2 b + 1 d u = 1 λ r + 1 0 ( u 1 ) ( r + 1 ) 1 u 2 m b + 2 b + 1 d u = 1 λ r + 1 B ( r + 1 , 2 m b + 2 b + 1 ( r + 1 ) ) = 1 λ r + 1 B ( r + 1 , 2 m b + 2 b r ) = Γ ( r + 1 ) Γ ( 2 m b + 2 b r ) λ r + 1 Γ ( 2 m b + 2 b + 1 )
which is a beta function over a half line. Therefore, the r t h moment is given by
E ( X r ) = i , j , m = 0 ( 1 ) j + m 2 α b θ i + 1 ( e θ 1 ) i ! λ r i j α + j 1 m Γ ( r + 1 ) Γ ( 2 m b + 2 b r ) λ r + 1 Γ ( 2 m b + 2 b + 1 ) .
This result is important in determining the moments and measures of central tendency and dispersion (standard deviation (SD), coefficient of variation (CV), coefficient of skewness (CS), and coefficient of kurtosis (CK)). Table 2 presents the first five moments and the measures of dispersion for selected parameter values ( α , b , λ , a n d θ ).
The moment generating function of the TL-LxP is given by
M X ( t ) = E [ e t X ] = p = 0 t p E [ X p ] p ! = i , j , m , p = 0 ( 1 ) j + m 2 α b θ i + 1 ( e θ 1 ) i ! p ! λ p i j α + j 1 m Γ ( p + 1 ) Γ ( 2 m b + 2 b p ) λ p + 1 Γ ( 2 m b + 2 b + 1 )

3.3. Distribution of Order Statistics

The pdf of the i t h order statistics is given by
f i : n ( x ) = n ! f ( x ) ( i 1 ) ! ( n i ) ! q = 0 ( 1 ) q n 1 q [ F ( x ) ] q + i 1 = n ! 2 α b λ θ ( 1 + λ x ) ( 2 b + 1 ) ( i 1 ) ! ( n i ) ! ( e θ 1 ) [ 1 ( 1 + λ x ) 2 b ] α 1 exp [ θ ( 1 [ 1 ( 1 + λ x ) 2 b ] α ) ] × q = 0 ( 1 ) q n 1 q 1 exp [ θ ( 1 [ 1 ( 1 + λ x ) 2 b ] α ) ] 1 e θ 1 q + i 1 = n ! 2 α b λ θ ( i 1 ) ! ( n i ) ! q , s , t = 0 ( 1 ) q + s + t ( 1 + t ) ( 1 + t ) ( e θ 1 ) s + 1 n 1 q q + i 1 s s t ( 1 + λ x ) ( 2 b + 1 ) × [ 1 ( 1 + λ x ) 2 b ] α 1 exp [ θ ( 1 + t ) ( 1 [ 1 ( 1 + λ x ) 2 b ] α ) ]
which is a linear combination of exponentiated TL-Lx distribution.

3.4. Rényi Entropy

The two commonly used measures of uncertainty are Shannon [16] and Rényi [14] entropies. Rényi entropy is a generalization of the Shannon entropy, hence, we will derive only the Rényi entropy in this paper. Rényi entropy for the TL-LxP distribution is derived as follows:
I R ( ν ) = 1 1 ν log 0 [ f ( x ; α , b , λ , θ ) ] ν d x .
[ f ( x ; α , b , λ , θ ) ] ν = 2 α b λ θ e θ 1 ν ( 1 + λ x ) ( 2 b ν + ν ) [ 1 ( 1 + λ x ) 2 b ] α ν ν × exp [ θ ν ( 1 [ 1 ( 1 + λ x ) 2 b ] α ) ] = 2 α b λ θ e θ 1 ν t , s , u = 0 ( 1 ) t + u ( θ ν ) s s ! s t α t + α ν ν u ( 1 + λ x ) 2 b u 2 b ν ν .
Now
0 ( 1 + λ x ) 2 b u 2 b ν ν d x = 0 d x ( 1 + λ x ) 2 b u + 2 b ν + ν .
Let u = 1 + λ x d u = λ d x d x = 1 λ d u . When x = 0 , u = 1 and when x = , u = . Note
1 ( t 1 ) a t b = B ( a + 1 , b a 1 ) = Γ ( a + 1 ) Γ ( b a 1 ) Γ ( b ) .
Hence,
1 d x ( 1 + λ x ) 2 b u + 2 b ν + ν = 1 λ 1 ( u 1 ) 1 1 ( 1 + λ x ) 2 b u + 2 b ν + ν = 1 λ Γ ( 1 ) Γ 2 b u + 2 b ν + ν 1 Γ ( 2 b u + 2 b ν + ν ) = 1 λ ( 2 b u + 2 b ν + n u 1 ) .
Therefore, we define Rényi entropy of the TL-LxP distribution by
I R ( ν ) = 1 1 ν log 2 α b λ θ e θ 1 ν t , s , u = 0 ( 1 ) t + u ( θ ν ) s s ! s t α t + α ν ν u 1 λ ( 2 b u + 2 b ν + n u 1 ) .

4. Estimation

If X i T L L x P ( α , b , λ , θ ) with the parameter vector Δ = ( α , b , λ , θ ) T . The total log-likelihood = ( Δ ) from a random sample of size n is given by
= n ln [ 2 α b λ θ ] ( 2 b + 1 ) i = 1 n ln [ 1 + λ x ] + ( α 1 ) i = 1 n ln [ 1 ( 1 + λ x ) 2 b ] + i = 1 n θ [ 1 ( 1 [ 1 + λ x ] 2 b ) α ] i = 1 n ( e θ 1 ) .
The elements of the score vector U = α , b , λ , θ are given below
α = n α + i = 1 n ln [ 1 ( 1 + λ x ) 2 b ] i = 1 n θ [ 1 ( 1 + λ x ) 2 b ] α ln [ 1 ( 1 + λ x ) 2 b ] ,
b = n b 2 i = 1 n ln [ 1 + λ x ] + 2 ( α 1 ) i = 1 n ln [ 1 + λ x ] ( 1 + λ x ) 2 b 1 ( 1 + λ x ) 2 b 2 i = 1 n θ α ln [ 1 + λ x ] ( 1 + λ x ) 2 b [ 1 ( 1 + λ x ) 2 b ] α 1 ,
λ = n λ ( 2 b + 1 ) i = 1 n λ 1 + λ x + 2 ( α 1 ) i = 1 n b x ( 1 + λ x ) 2 b 1 1 ( 1 + λ x ) 2 b 2 i = 1 n θ b α x ( 1 + λ x ) 2 b ( 1 [ 1 + λ x ] 2 b ) α 1 ,
. and
θ = n θ + i = 1 n 1 [ 1 ( 1 + λ x ) 2 b ] α n ,
respectively. The solutions to the nonlinear equation α , b , λ , θ T = 0 , gives the maximum likelihood estimates of the model parameters.

5. Simulations

To evaluate the consistency of the model parameter estimation technique. A Monte Carlo simulation study was conducted. Results for the simulation study are summarised in Table Table 3. A simulation study was conducted for sample sizes n= 20, 40, 60,120, 240 and 480 for N=3000 repetitions from the TLL-LxP distribution. The average bias (AB) and root mean square error (RMSE) for an estimated parameter, say ( Φ ^ ), is calculated using the following formulae
A B I A S ( Φ ^ ) = i = 1 N Φ ^ i N Φ , and R M S E ( Φ ^ ) = i = 1 N ( Φ ^ i Φ ) 2 N ,
respectively. The simulation study results demonstrates that the parameter estimates from the TL-LxP distribution are consistent since the mean values approaches the true parameter values for increasing sample size. Furthermore, RMSE and ABias decays as the sample size increases demonstrating consistence in the parameter estimation process. The results are presented in Table Table 3.

6. Inference

To assess the utility of the new compounded model. Three real data sets are used for demonstration purposes. The TL-LxP distribution was compared to the TL-Lx by Oguntunde et al. [13], exponentiated Lomax (Exp-Lx) by Abdul-Moniem and Abdel-Hammed [2], exponential Lomax (E-Lx) by Bassiouny et al. [5], and the Weibull-Lomax (W-Lx) by Tahir et al. [17]. Various goodness-of-fit (GoF) statistics were used to assess model performance. The GoF statistics used are the -2log-likelihood statistic ( 2 ln ( L ) ) , Akaike Information Criterion (AIC), Bayesian Information Criterion (BIC) and Consistent Akaike Information Criterion (AICC), Cramér-von Mises ( W * ) and Anderson-Darling ( A * ). Generally, a good fitting model is expect to have smaller values for all the GoF statistics. Graphical displays were further used to demonstrate how the proposed model fit the data sets. The graphs considered are the histogram of data and fitted pdf, probability plot, fitted cdf, Kaplan-Meier curves, scaled total time on test (TTT) transform proposed by Aarset [1] and the fitted hazard rate function. Data analysis results are presented in Table 4 and Table 5

6.1. Failure Times Data

The first dataset represents time to failure of 59 test conductors of 400 micrometer length. The specimens were subjected to high temperature and current density. The times to failure in hours for the 59 test conductors are shown below. 6.545, 9.289, 7.543, 6.956, 6.492, 5.459, 8.120, 4.706, 8.687,2.997, 8.591, 6.129, 11.038, 5.381, 6.958, 4.288, 6.522, 4.137, 7.459, 7.495, 6.573, 6.538, 5.589, 6.087, 5.807, 6.725, 8.532, 9.663,6.369, 7.024, 8.336, 9.218, 7.945, 6.869, 6.352, 4.700, 6.948, 9.254, 5.009, 7.489, 7.398, 6.033, 10.092, 7.496, 4.531, 7.974, 8.799, 7.683, 7.224, 7.365, 6.923, 5.640, 5.434, 7.937, 6.515, 6.476, 6.071, 10.491, 5.923.
Table 4 shows the model parameters and GoF statistics for the new model and some selected competing models. The standard errors for the parameter estimates are given in parenthesis. The estimated variance-covariance matrix for the TL-LxP model on the failure times dataset is given by
2.5478 1.7123 0.0118 0.3297 1.7123 1.1507 0.0079 0.2216 0.0118 0.0079 5.5589 × 10 5 0.0015 0.3297 0.2216 0.0015 0.0426
with the approximate asymptotic 95 % two-sided confidence intervals for the parameter estimates α , b , λ and θ given by 10.6068 ± 3.1286 ,   3.2757 ± 2.1026 , 0.0291 ± 0.0146 and 30.7911 ± 0.4049 , respectively.
The results presented in Table 4 shows that the TL-LxP distribution performs better than the other selected generalizations of the Lomax distribution available in the literature. This is supported by the evidence that the TL-LxP distribution has lower values for all the GoF statistics compared to the selected competing models. Graphical plots from the fitted model also show how good the TL-LxP distribution performs on the failure times dataset.

6.2. Red Cells Data

The second dataset represents red cell counts of 202 athletes from Australia. The data are was obtained from the sn package of the R software. The observations are as follows: 3.80, 3.90, 3.90, 3.91, 3.95, 3.95, 3.96, 3.96, 4.00, 4.02, 4.03, 4.06, 4.07, 4.08, 4.09, 4.09, 4.10, 4.11, 4.11, 4.12, 4.13, 4.13, 4.14, 4.15, 4.16, 4.16, 4.17, 4.17, 4.19, 4.20, 4.20, 4.21, 4.23, 4.23, 4.24, 4.24, 4.25, 4.26, 4.26, 4.27, 4.27, 4.30, 4.31, 4.31, 4.32, 4.32, 4.32, 4.35, 4.36, 4.36, 4.37, 4.38, 4.38, 4.39, 4.40, 4.40, 4.40, 4.41, 4.41, 4.41, 4.42, 4.42, 4.44, 4.44, 4.44, 4.45, 4.45, 4.46, 4.46, 4.46, 4.46, 4.46, 4.48, 4.49, 4.50, 4.50, 4.51, 4.51, 4.51, 4.51, 4.52, 4.53, 4.54, 4.55, 4.56, 4.57, 4.58, 4.62, 4.63, 4.63, 4.63, 4.64, 4.66, 4.68, 4.71, 4.71, 4.71, 4.71, 4.73, 4.75, 4.75, 4.76, 4.77, 4.77, 4.78, 4.81, 4.81, 4.82, 4.82, 4.83, 4.83, 4.83, 4.83, 4.84, 4.86, 4.86, 4.87, 4.87, 4.87, 4.87, 4.87, 4.87, 4.88, 4.89, 4.89, 4.90, 4.90, 4.91, 4.91, 4.92, 4.93, 4.93, 4.94, 4.95, 4.95, 4.96, 4.97, 4.97, 4.98, 4.99, 5.00, 5.00, 5.00, 5.01, 5.01, 5.01, 5.02, 5.02, 5.03, 5.03, 5.03, 5.03, 5.04, 5.04, 5.08, 5.09, 5.09, 5.09, 5.10, 5.11, 5.11, 5.11, 5.11, 5.11, 5.13, 5.13, 5.13, 5.13, 5.16, 5.16, 5.16, 5.16, 5.17, 5.17, 5.18, 5.21, 5.21, 5.22, 5.22, 5.24, 5.24, 5.25, 5.29, 5.31, 5.32, 5.33, 5.33, 5.34, 5.34, 5.34, 5.34, 5.38, 5.40, 5.48, 5.48, 5.49, 5.50, 5.59, 5.66, 5.69, 5.93, 6.72.
It can be observed from the results shwon in Table 5 that the TL-LxP distribution performs better on red cell counts data compared to the other selected models since it has the smallest values for the goodness-of-fit statistics.
The estimated variance-covariance matrix for the TL-LxP model for Red cells dataset is given by
2.2023 × 10 17 1.5450 × 10 15 9.1006 × 10 13 1.8641 × 10 16 1.5450 × 10 15 1.0839 × 10 13 6.3844 × 10 11 1.3077 × 10 14 9.1006 × 10 13 6.3844 × 10 11 3.7606 × 10 8 7.7029 × 10 12 1.8641 × 10 16 1.3077 × 10 14 7.7029 × 10 12 1.5778 × 10 15
and the approximate 95 % two-sided confidence intervals for the parameter estimates are α , b , λ and θ are given by 275.1900 ± 9.1981 × 10 9 ,   18.0300 ± 6.4529 × 10 7 , 0.0287 ± 3.8009 × 10 4 and 12.1300 ± 7.7855 × 10 8 , respectively.

6.3. Acute Bone Cancer Data

The third dataset represents the survival times (in days) of 73 patients diagnosed with acute bone cancer as reported by Mansour et al. [10]. The data are as follows: 0.09, 0.76, 1.81, 1.10, 3.72, 0.72, 2.49, 1.00, 0.53, 0.66, 31.61, 0.60, 0.20, 1.61, 1.88, 0.70, 1.36, 0.43, 3.16, 1.57, 4.93, 11.07, 1.63, 1.39, 4.54, 3.12, 86.01, 1.92, 0.92, 4.04, 1.16, 2.26, 0.20, 0.94, 1.82, 3.99, 1.46, 2.75, 1.38, 2.76, 1.86, 2.68, 1.76, 0.67, 1.29, 1.56, 2.83, 0.71, 1.48, 2.41, 0.66, 0.65, 2.36, 1.29, 13.75, 0.67, 3.70, 0.76, 3.63, 0.68, 2.65, 0.95, 2.30, 2.57, 0.61, 3.93, 1.56, 1.29, 9.94, 1.67, 1.42, 4.18, 1.37.
Furthermore, results presented in Table 6 supports the superiority of the TL-LxP distribution compared to the other selected models. From the plots of the fitted densities (Figure 2, Figure 5 and Figure 8), we observe that the model is applicable to data containing some outlying values and that the model is applicable to data with increasing or non monotonic failure rates as shown in Figure 4, Figure 7 and Figure 10.
The estimated variance-covariance matrix for the TL-LxP model for acute bone cancer dataset is given by
0.5494 0.0559 0.2477 0.1902 0.0559 0.0978 0.0999 0.4936 0.2477 0.0999 0.1845 0.2232 0.1902 0.4936 0.2232 4.1950
and the approximate 95 % two-sided confidence intervals for the parameter estimates are α , b , λ and θ are given by 2.5917 ± 1.4528 ,   0.5558 ± 0.6130 , 0.5351 ± 0.8418 and 4.1833 ± 4.0144 , respectively.

7. Concluding Remarks

A new compounded distribution was developed. The new distribution is a generalization of the Lomax distribution via the Topp-Leone generalization and compounding using the Poisson distribution. Statistical properties for this distribution were derived. Results from applications to real datasets of the new model shows the utility of the proposed model in comparison to some selected models.

References

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Figure 1. PDF Plots for TL-LxP Distribution.
Figure 1. PDF Plots for TL-LxP Distribution.
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Figure 2. Fitted Densities and Probability Plots for Failure Times Data.
Figure 2. Fitted Densities and Probability Plots for Failure Times Data.
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Figure 3. Fitted K-M and ECDF Plots for Failure Times Data.
Figure 3. Fitted K-M and ECDF Plots for Failure Times Data.
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Figure 4. Fitted TTT and HRF Plots for Failure Times Data.
Figure 4. Fitted TTT and HRF Plots for Failure Times Data.
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Figure 5. Fitted Densities and Probability Plots for Red Cells Count Data.
Figure 5. Fitted Densities and Probability Plots for Red Cells Count Data.
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Figure 6. Fitted K-M and ECDF Plots for Red Cells Data.
Figure 6. Fitted K-M and ECDF Plots for Red Cells Data.
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Figure 7. Fitted TTT and HRF Plots for Red Cells Data.
Figure 7. Fitted TTT and HRF Plots for Red Cells Data.
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Figure 8. Fitted Densities and Probability Plots for Acute Bone Cancer Data.
Figure 8. Fitted Densities and Probability Plots for Acute Bone Cancer Data.
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Figure 9. Fitted K-M and ECDF Plots for Acute Bone Cancer Data.
Figure 9. Fitted K-M and ECDF Plots for Acute Bone Cancer Data.
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Figure 10. Fitted TTT and HRF Plots for Acute Bone Cancer Data.
Figure 10. Fitted TTT and HRF Plots for Acute Bone Cancer Data.
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Table 1. Quantile values for selected parameter values.
Table 1. Quantile values for selected parameter values.
u (1.5,1.5,0.1,1.5) (0.5,1,0.5,0.9) (1.5,0.5,0.3,1.5) (0.5,1.5,0.9,0.5) (1.1,1.1,0.3,0.6)
0.1 0.5267 0.00461 0.5549 0.0024 0.1585
0.2 0.9252 0.0200 1.0134 0.0101 0.3278
0.3 1.3448 0.04923 1.5337 0.0244 0.5264
0.4 1.8225 0.0973 2.1748 0.0472 0.7693
0.5 2.3994 0.1731 3.0212 0.0818 1.0792
0.6 3.1417 0.2929 4.2321 0.1344 1.4967
0.7 4.1807 0.4918 6.1721 0.2176 2.1059
0.8 5.8442 0.8624 9.9251 0.3628 3.1224
0.9 9.3687 1.7807 20.8868 0.6879 5.3899
Table 2. First five moments and measures of dispersion for selected parameter values.
Table 2. First five moments and measures of dispersion for selected parameter values.
(1.5,1.5,0.1,1.5) (0.5,1,0.5,0.9) (1.1,0.5,0.8,1.5) (1.5,1.5,0.9,0.5) (1.1,0.9,0.3,0.6)
E [ X ] 0.1208 0.1736 0.2224 0.2903 0.1827
E [ X 2 ] 0.0823 0.0873 0.1277 0.1540 0.1139
E [ X 3 ] 0.0622 0.0569 0.0878 0.1002 0.0820
E [ X 4 ] 0.0498 0.0419 0.0664 0.0730 0.0638
E [ X 5 ] 0.0415 0.0331 0.0532 0.0570 0.0521
SD 0.2603 0.2390 0.2797 0.2641 0.2838
CV 2.1555 1.3770 1.2579 0.9096 1.5535
CS 2.0333 1.6097 1.1231 0.8146 1.3891
CK 5.7439 4.7457 3.0822 2.7208 3.6022
Table 3. Monte Carlo Simulation Results for the TL-LxP Distribution: Mean, RMSE and AB.
Table 3. Monte Carlo Simulation Results for the TL-LxP Distribution: Mean, RMSE and AB.
(1, 1, 0.4, 1) (1.0, 1.1, 0.4, 1.1)
n Mean RMSE Bias Mean RMSE Bias
40 1.1187 0.4721 0.1187 1.1094 0.3637 0.1094
80 1.0418 0.2124 0.0418 1.0438 0.2134 0.0438
α 100 1.0287 0.1808 0.0287 1.0268 0.1863 0.0268
200 1.0141 0.1252 0.0141 1.0101 0.1200 0.0101
400 1.0003 0.0886 0.0003 1.0008 0.0886 0.0008
40 3.0728 4.6544 2.0728 3.4046 5.1203 2.3046
80 2.1885 3.0581 1.1885 2.5260 3.6024 1.4260
b 100 1.8541 2.4040 0.8541 2.2194 2.9517 1.1194
200 1.3472 1.2323 0.3472 1.6549 1.8163 0.5549
400 1.1522 0.5702 0.1522 1.3192 0.7852 0.2192
40 0.5926 3.1108 0.1926 0.4847 0.6640 0.0847
80 0.3932 0.3985 -0.0068 0.4118 0.4269 0.0118
λ 100 0.3985 0.3761 -0.0015 0.4036 0.4167 0.0036
200 0.3823 0.2763 -0.0177 0.3832 0.2979 -0.0168
400 0.3670 0.2154 -0.0330 0.3746 0.2305 -0.0254
40 1.7883 1.3726 0.7883 1.8600 1.3326 0.7600
80 1.6869 1.2467 0.6869 1.7232 1.2241 0.6232
θ 100 1.6333 1.1739 0.6333 1.7066 1.1771 0.6066
200 1.5767 1.1279 0.5767 1.6617 1.1304 0.5617
400 1.4849 1.0079 0.4849 1.5532 1.0065 0.4532
(1, 1.1, 0.4, 0.9) (1.0, 1,0, 1.1, 1.1)
n Mean RMSE Bias Mean RMSE Bias
40 1.1179 0.4445 0.1179 1.1161 0.4619 0.1161
80 1.0481 0.2139 0.0481 1.0401 0.2156 0.0401
α 100 1.0297 0.1878 0.0297 1.0280 0.1891 0.0280
200 1.0156 0.1221 0.0156 1.0100 0.1204 0.0100
400 1.0010 0.0878 0.0010 1.0014 0.0876 0.0014
40 3.3695 4.9285 2.2695 4.7556 8.7554 3.7556
80 2.4850 3.3800 1.3850 3.3262 6.3080 2.3262
b 100 2.2942 2.9945 1.1942 2.5351 4.6243 1.5351
200 1.6291 1.6175 0.5291 1.4946 2.0599 0.4946
400 1.3773 0.8805 0.2773 1.1591 0.7450 0.1591
40 0.4667 0.7443 0.0667 2.2409 19.8829 1.1409
80 0.3895 0.4034 -0.0105 1.0952 1.1146 -0.0048
λ 100 0.3831 0.3863 -0.0169 1.1261 1.1634 0.0261
200 0.3640 0.2778 -0.0360 1.0627 0.7570 -0.0373
400 0.3461 0.2167 -0.0539 1.0402 0.6162 -0.0598
40 1.7507 1.3448 0.8507 1.9460 1.7794 0.8460
80 1.6485 1.2425 0.7485 1.8051 1.3196 0.7051
θ 100 1.5747 1.1319 0.6747 1.7437 1.2722 0.6437
200 1.5370 1.0988 0.6370 1.6684 1.1725 0.5684
400 1.4525 0.9974 0.5525 1.5819 1.1029 0.4819
Table 4. Parameter Estimates and Goodness-of-Fit Statistics for Failure Times Data.
Table 4. Parameter Estimates and Goodness-of-Fit Statistics for Failure Times Data.
Estimates Statistics
Model α b λ θ 2 log A I C A I C C B I C W * A *
TL-LxP 10.6068 3.2757 0.0291 30.7911 222.65 230.65 231.40 238.96 0.0354 0.2003
(1.5962) (1.0727) (0.0075) (0.2066)
TL-Lx 53.9590 154.2200 0.0021 - 230.05 236.05 236.49 242.28 0.1061 0.6512
(6.9886 × 10 10 ) (9.9495 × 10 10 ) (7.2301 × 10 5 ) -
Exp-Lx 53.2240 - 0.0015 424.1200 230.01 236.01 236.44 242.24 0.1053 0.6467
(3.7181 × 10 10 ) - (5.2423 × 10 5 ) (1.8960 × 10 10 )
E-Lx 101.2300 155.7100 0.0071 - 234.90 240.90 241.34 247.13 0.2237 1.2920
(3.5910 × 10 7 ) (2.2705 × 10 7 ) (0.0009) -
α a b -
W-Lx 9.5584 0.2642 1.6864 - 224.02 230.02 230.46 236.28 0.0669 0.3739
(9.7424) (0.3376) 6.0967 -
Table 5. Parameter Estimates and Goodness-of-Fit Statistics for Red Cells Data.
Table 5. Parameter Estimates and Goodness-of-Fit Statistics for Red Cells Data.
Estimates Statistics
Model α b λ θ 2 log A I C A I C C B I C W * A *
TL-LxP 275.1900 18.0300 0.0287 12.1300 252.25 260.25 260.45 273.48 0.2756 1.4905
(4.6929 × 10 9 ) (3.2923 × 10 7 ) (1.9392 × 10 4 ) (3.9722 × 10 8 )
TL-Lx 2.3999 × 10 4 7.0413 × 10 3 1.5861 × 10 4 - 262.89 268.89 269.01 278.82 0.4186 2.3022
(7.6362 × 10 16 ) (2.5623 × 10 14 ) (1.1394 × 10 6 ) -
Exp-Lx 2.7839 × 10 4 - 3.6145 × 10 4 6.2847 × 10 3 261.95 267.95 268.07 277.87 0.422 2.3240
(3.3390 × 10 15 ) - (2.5735 × 10 6 ) (1.4804 × 10 13 )
E-Lx 79.4110 46.9440 3.7495 × 10 4 - 343.91 349.91 359.71 353.81 0.2664 2.1860
(1.0190 × 10 9 ) (1.6366 × 10 9 ) (2.6382 × 10 5 ) -
α a b -
W-Lx 14.1610 0.4390 0.7813 - 293.41 299.41 299.54 309.34 0.2224 1.8017
(1.1162) (0.0465) (0.1648) -
Table 6. Parameter Estimates and Goodness-of-Fit Statistics for Acute Bone Cancer Data.
Table 6. Parameter Estimates and Goodness-of-Fit Statistics for Acute Bone Cancer Data.
Estimates Statistics
Model α b λ θ 2 log A I C A I C C B I C W * A *
TL-LxP 2.5917 0.5558 0.5351 4.1833 278.29 286.29 286.88 295.45 0.0568 0.4391
(0.7412) (0.3128) (0.4295) (2.0482)
TL-Lx 3.3768 0.9318 0.9169 - 281.67 287.67 288.02 294.54 0.0919 0.6886
(1.1532) (0.2168) (0.9169) -
Exp-Lx 3.3768 - 0.9169 1.8637 281.67 287.67 288.02 294.54 0.0919 0.6886
(1.1532) - (0.5215) (0.4337)
E-Lx 0.7659 2.6643 × 10 5 1.3793 × 10 4 - 322.81 328.81 329.15 335.68 0.6017 3.6470
(9.2412 × 10 6 ) (3.3325 × 10 4 ) (1.3220 × 10 3 ) -
α a b -
W-Lx 1.7750 0.2582 5.0702 - 300.52 306.52 306.87 313.87 0.3067 1.9958
(0.4286) (0.0759) (4.3144) -
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