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Nutritional Values of Wheat and the Roles and Functions of Its Compositions in Health

Submitted:

03 September 2024

Posted:

09 September 2024

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Abstract
Over 3.0 billion people of the 7.75 billion globally suffer from malnutrition due to deficiencies in micronutrients, particularly iron, zinc, and vitamins (such as vitamin A, B complex, E, and folate, etc.). In response, there is growing consumer interest in foods that provide traditional nutrients and contain additional compounds beneficial to health and well-being. Wheat is the most important cereal crop in terms of both production and consumption, contributing about 30% of total cereal consumption worldwide. It provides a significant source of carbohydrates and gluten protein (around 12-14% protein), which supply substantial energy. Wheat grain is also rich in various nutrients, such as macro-elements like phosphorus (P), potassium (K), calcium (Ca), and magnesium (Mg); microelements like iron (Fe), zinc (Zn), manganese (Mn), and vitamins B complex: thiamin (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7), folate (B9), additionally soluble fiber and other trace minerals which are higher than in other major cereals. The inner bran coats, phosphates, and other mineral salts in wheat contribute to its beneficial effects on bowel movements. Despite its nutritional benefits, the quality of wheat's nutrients is a topic of ongoing discussion. Exploring ways to enhance the nutritional quality of wheat could provide valuable insights for scientists working to improve global nutrition status.
Keywords: 
Gluten proteins
;  
Nutritional quality
;  
Vitamins and minerals
;  
Wheat grain
Subject: 
Biology and Life Sciences  -   Plant Sciences
Highlights
  • Wheat is more enriched in crude protein (2-14%), vitamins, minerals, insoluble fiber, etc. than other major cereals.
  • Wheat contains higher vitamin E (30 mg/100 grains) than other cereals acting as radical scavengers (Antioxidant).
  • It contains more B complexes, especially Riboflavin (B2) and folate (B9) produce and maintain new cells, (especially red blood cells), and also prevent DNA changes that might cause cancer.

Introduction

Cereal grains, particularly wheat (Triticum sp.), play important roles in meeting the growing global population’s food demand. Wheat, also known as bread wheat, is grown all over the world and contains higher calories, protein, fiber, vitamins, and minerals than other cereals, especially rice which is the second staple food of the world's people. Wheat is the most traded cereal crop in the international agricultural food market. It is considered a good source of nutritional value [1]. Over 3.0 billion individuals suffer from micronutrient deficiencies, particularly iron, zinc, vitamin B complex, and vitamin A [2]. Enriching key staple food crops with micronutrients through plant breeding procedures is one sustainable agricultural strategy for reducing micronutrient deficiency among those at greatest risk (resource-poor mothers, babies, and children) worldwide.
The seeds of wheat are used to make flour and semolina, the main ingredients in bread and other baked goods. Wheat contains protein, minerals, fiber, phenol, flavonoid, anthocyanin, vitamin C, and antioxidants that are beneficial for human and animal health [3]. As phenolic acids can be absorbed and digested by the large and small intestines, the risk of colorectal cancer can be reduced, providing health benefits [4]. Vitamin C reduces the risk of scurvy, and flavonoids promote the consumption of products. As anthocyanins and carotenoids have antioxidant activity, these phytochemicals could be valuable products for human health [5].
Various treatments are used to enhance the content of antioxidants and bioactive compounds, especially phenolics, flavonoids, carotenoids, and anthocyanins in wheat [5,6,7,8,9]. Different treatments, especially salt (Islam et al. 2019), selenium [5], salicylic acid [7], temperature [8], and water-deficit conditions increased bioactive compounds and antioxidant activity in wheatgrass and microgreens due to the phenylalanine biosynthesis pathway [5,6,7,8,9]. As the global population is increasing, food demand is also increasing. To fulfill the demand, wheat production should increase as land is not increasing. In this aspect, high-yielding wheat species should be introduced. To identify the high-yielding variety along with its high nutritional value, researchers should focus on responsible gene variation. Therefore, this review was conducted to focus on the nutritional value of wheat and the roles and functions of its compositions in health.

Uses of Wheat

There are endless uses of wheat flour in farming, medicine, cooking, and baking. Wheat is a leading cereal crop, mainly utilized for human consumption and livestock feed. All kinds of flour products made of wheat flour have established themselves as the staple food on people's dining tables. Whole wheat flour provides a richer, more nuanced flavor than white flour because it retains the wheat bran and germ [10]. Excessive processing and milling in wheat flour production cause losses of nutrients such as vitamins, minerals, and dietary fibers [11]. The production of whole-grain wheat flour requires far less technological processing than separately isolating wheat bran from the grain during the production of refined flour. Instead of leaving white bran to waste, it is currently used in the food industry because of its beneficial components [11].

Uses of Different Types of Wheat Flour

Flour is produced from grinding and milling wheat kernels. However, different kinds of flour are produced for specific purposes. Even though they're all made from grinding wheat, these different types of flour vary significantly depending on protein content, fineness, and more. All the different kinds of flour are described as follows:
All-purpose flour: The finely ground wheat kernel, which was separated from the bran and germ during milling, is known as all-purpose flour [12]. All-purpose flour is made from hard wheat or a mixture of soft and hard wheat. This flour can be used to bake various products and prepare yeast bread, cookies, cakes, noodles, and pastries [13].
Whole wheat flour: Whole wheat flour is prepared from the entire wheat kernel and thus contains the bran, germ, and endosperm. Most commercial whole wheat flour is prepared by reintroducing the germ and bran back into refined white flour rather than milling entire wheat grains [12]. As a result, whole wheat flour baked goods are denser and heavier than white flour baked goods.
Bleached flour: Flour that has been treated with a bleaching chemical, such as benzoyl peroxide. Some flour is also given a maturing agent treatment, which alters the starch content of the flour itself, typically by oxidizing it. This enables the wheat to absorb more liquid and change into a thicker dough, either dampening or enhancing the production of gluten. For baking pastries, cakes, and cookies, bleached flour is preferable [14].
Unbleached flour: Unbleached flour is any flour that has not undergone the bleaching process and does not contain any trace preservative chemicals. Unbleached flour is desirable when making yeast dough [14].
Bread flour: Bread flour is flour with particularly high gluten protein content, up to about 14 percent. Bread is a widely consumed food made from highly refined wheat flour. Bread flour, from the endosperm of the wheat kernel, is milled primarily for commercial bakers but is also available at retail outlets [12]. While yeast ferments during the early stages of baking bread, carbon dioxide gets trapped by the protein-bonded flour, resulting in stretchy dough with air pockets in the crumb. Although it is similar to all-purpose flour, bread flour has greater gluten strength and is generally used for yeast bread [14]. Flatbreads are produced in more than 60 varieties and have been traditional dishes for many years. Pita is a particular type of flatbread (Arabic bread). Different countries have names for similar bread varieties, such as baladi in Egypt, bouri in Saudi Arabia, or source in Libya and North Africa [14]). Pita bread has a rounded shape, a pocket that forms while baking, and a crust that is a deep golden hue.
Cake flour: Cake flour is milled from soft wheat and is especially suitable for cakes, cookies, crackers, and pastries that are low in protein and gluten. To mimic the effects of cake flour with all-purpose flour, remove two tablespoons of flour and replace them with two tablespoons of corn starch, which will prevent the formation of gluten to a similar effect [12].
Pastry flour: Pastry flour is milled from soft, low-gluten wheat. These are low-protein, and the high-gluten formula has a superfine consistency comparable in protein but lower in starch than cake flour. Whole wheat pastry flour contains wheat germ, bran, and endosperm, ground super fine [12].
Self-rising flour: Self-rising flour is like all-purpose flour combined with leavening agents (salt and baking powder), which adds airiness by releasing gas bubbles in the dough. For baked items like scones, biscuits, and muffins self-rising flour is often utilized [12].
Durum flour: Durum flour is made from durum wheat (Triticum durum). It yields high-protein flour and commercial U.S. noodles suitable for bread and pasta with a pale-yellow color [14,15].
Semolina flour: Coarsely ground endosperm of durum wheat high in protein. Used in high-quality pasta products, it contains more proteins [14].
Gluten flour: When used by bakers in combination with flour, it has low protein content because it improves the baking quality and produces high-protein gluten bread [12,14].
Farina flour: Hard wheat endosperm that has been coarsely ground. The prime ingredient in many U.S. breakfast portions of cereal is also used in the production of low-cost pasta with very little saturated fat. There is no cholesterol, low sodium, very little sugar, a lot of fiber, a lot of manganese, and a lot of phosphorus [12].

The Uses of Wheat in Farming

Ruminant animal production: For animals with several stomachs, such as ruminants, wheat is a great source of animal nutrition. Wheat has high protein values, up to 18%, depending on species, cultivation, and growth conditions. It can be used to feed ruminants instead of grass because it has more protein and more energy than it [16].
Swine production: In swine, wheat bran is used for its nutritional properties and digestion. Wheat bran is supplemented in the diet of pigs because it improves the intestinal flora and promotes intestinal health [17]. Additionally, the fiber in wheat bran can be fermented by the bacteria in pigs' large intestines to create volatile fatty acids that the animals can use as a source of energy [16]. Nevertheless, it is advised to add enzymatic products, such as Alquerzim, to the wheat bran to increase its digestibility.
Poultry farming: In poultry farming, wheat is common in Asia, Australia, Canada, and Europe due to the shortage of corn during some seasons. Although wheat provides less energy than maize, it does contain more crude protein and amino acids like lysine and tryptophan [18]. Additionally, compared to corn, wheat has lower levels of biotin and vitamin A. Therefore, it is not advised to include a significant amount or for extended periods due to these reasons [16]. However, wheat is a great substitute for chicken feed since it promotes the production of pellets due to the presence of gluten, negating the need for binders [16].
Ethanol production: The majority of wheat consists of carbohydrates. Therefore, it can be used for ethanol production and brewing wheat beer [12].

Chemical Composition and Nutritional Value of Wheat

Proximate composition: Protein is one of the most important nutrients for both people and animals. Its name, which comes from the Greek word for "primary," shows how important it is. Gluten makes up 80% of total wheat protein and is responsible for the elasticity and stickiness of bread dough [19]. The fat content in wheat flour was low, at 0.84% [20]. Wheat flour is rich in carbohydrates. The carbohydrate content of wheat flour was 72.73% [20]. Wheat flour had 84.5% carbohydrate content, but 58% starch content [21]. Wheat grains store energy in the form of starch, which can be as much as 75% of the dry weight of the grain or more. The amount of starch contained in a wheat grain may vary between 60% and 75%, depending on the type of grain [22]. Whole-grain wheat contains 7.0-22% of the dry-weight fiber [20,23,24], but refined wheat contains almost none, as the fiber is concentrated in the bran [19]. The main types of fiber in wheat bran are hemicellulose (70%) and cellulose [19]. Wheat contains high amounts of insoluble fiber and small amounts of soluble fiber (fructans) [25]. High-fiber diets have led to an increase in the demand for whole-grain and bran breads.
Vitamins: Whole-grain flours have considerably higher vitamin content than white flour due to the refining process [10,12,26]. As a result, wheat grains are naturally high in vitamins such as vitamin E (tocopherol or alpha-tocopherol) and B complex. The vitamin B complex consists of riboflavin (B2), thiamine (B1), niacin (B3), pyridoxine (B6), pantothenic acid (B5), biotin (B7), and folate (B9) [10]. The amount of vitamins in 100 mg of whole wheat grain is presented in Table 1. The following are the functions of various vitamins:
Vitamin E (tocopherol or alpha-tocopherol): An antioxidant, vitamin E, defends cell membranes against reactive oxygen species [28]. Vitamin E acts as a radical scavenger in this role, delivering a hydrogen (H) atom to free radicals. The lack of vitamin E can cause heart disease and nerve problems [29].
Thiamine (B1): Thiamine, is present in whole wheat flour and maintains many cellular activities. Thiamine pyrophosphate is a coenzyme that plays an essential role in the metabolism of carbohydrates and amino acids [30].
Riboflavin (B2): Vitamin B2 in whole wheat flour enables the production of red blood cells (RBCs). The greater the number of RBCs, the greater their contribution to energy generation in the body [31].
Niacin (B3): Niacin, included in whole wheat flour, helps the brain and mental health [31]. Niacin deficiency leads to pellagra, historically associated with diets based mainly on maize flour.
Pantothenic acid (B5): Whole wheat flour contains pantothenic acid, an essential nutrient [32]. Pantoic acid and alanine are combined to form pantothenic acid. All animals need pantothenic acid to produce coenzyme A (CoA), which is essential for fatty acid metabolism to synthesize and metabolize carbohydrates, proteins, and fats [32].
Pyridoxine (B6): Pyridoxine in whole wheat grain involves numerous aspects of cellular activities, such as neurotransmitter synthesis, macronutrient metabolism, histamine synthesis, and hemoglobin synthesis. pyridoxal 5'-phosphate (PLP) is usually a coenzyme (cofactor) for many reactions, including decarboxylation [33].
Biotin (B7): Biotin in whole wheat is engaged in various metabolic functions in people and other living things, primarily those that require using carbohydrates, lipids, and amino acids [34].
Folates (B9): Folate in whole wheat helps to produce and maintain new cells, especially red blood cells, in the body. It also helps prevent DNA changes that might cause cancer [13]. In addition, it's essential during pregnancy [35].
Table 1. Vitamins per 100 g of wheat grains.
Table 1. Vitamins per 100 g of wheat grains.
Vitamins Quantity/100 g of wheat Reference
Vitamin E 1.4 mg [10,36[
Niacin (B3) 5-18 mg [10,29,36]
Pantothenic acid (B5) 1.2-3.9 mg [10,36]
Thiamin (B1) 0.45-0.54 mg [10,29,36]
Pyridoxine (B6) 0.16-1.3 mg [10,29,36]
Folate (B9) 0.079-0.2 mg [10,29,36]
Riboflavin (B2) 0.39-0.75 mg [10,29,36]
Biotin (B7) 0.048 mg [10,36]
Folate (B9) (µg) 38.0 [10]

3. Minerals

Wheat mineral composition and its functions and deficiencies in the human body
Wheat is the world's most stable food. It is a cereal crop that has a major role in the world economy due to its production capacity and technological worth. Common wheat species (Triticum aestivum L.) serve as the main source of nutrition for humans, animals, and poultry arena. Global wheat production in 2021 was 775.4 million tons [37]. Regrettably, in the quest for efficiency and production, wheat has lost many important nutritional features (protein, carbohydrates, fiber, minerals, and vitamins) and flavor characteristics. As a result, there has been a recent rise in interest in the old variety, which is less productive but produces grain with higher nutritional content [38,39]. Additionally, older species like emmer, einkorn, and spelled are environment-friendly and require fewer pesticides and fertilizers for their cultivation [40].
Today, the world faces the biggest problem of mineral insufficiency in their bodies. Worldwide, mineral deficiency is affecting over three billion people. Premature deaths, poor labor productivity, and excessive healthcare expenditures have increased because of mineral deficiencies. Minerals are regarded as vital minerals that humans require in their everyday diets for healthy human growth [41]. Minerals are divided into two major groups: Macro-minerals, such as calcium (Ca), magnesium (Mg), phosphorus (P), potassium (K), sodium (Na), chloride (Cl), and sulfur (S), are needed in significant amounts every day, and micro-minerals, such as zinc (Zn), iron (Fe), fluoride (F), chromium (Cr), selenium (Se), boron (B), manganese (Mn), molybdenum (Mo) and copper (Cu), are also recognized as trace elements, which are required in smaller quantities, but important for living organism for metabolic activities, biological process, enzymatic activates, and molecular function [42,43,44]. The Recommended Daily Allowance (RDA) of macro- and microelements for sound human health is described in Table 2 [45]. Minerals are necessary for a variety of metabolic processes in the body, including enzyme activity. Micronutrient deficiencies, such as those in vitamins and minerals, might be responsible for similar chronic disorders [45].
The contents of minerals in wheat grains and wheat flour are shown in Table 3 and Table 4. The contents of macro- and micro-minerals in wheat grains may be mainly controlled by genetic and environmental factors. Mineral compositions in wheat grain vary from species to species [46] (Biel et al., 2021). Due to their nutritional value as well as their technological benefits, the elements beneficial for health are found in significant amounts in cereal grains. Crude ash and total protein were significantly higher in einkorn and emmer grains than in common wheat. Additionally, it demonstrates that compared to bread wheat, einkorn, and emmer may have a more varied mineral composition or a higher concentration of minerals (Table 5) [47,48].

Daily Requirements, Functions, and Deficiency of Minerals in the Human Body

Phosphorus: The RDA is 800-1300 mg per day. Phosphorus is linked to Ca homeostasis, bone and tooth development, and the most metabolic functions in the body, including kidney function, cell proliferation, and heart muscle contraction [51]. This element deficiency is uncommon, but symptoms include sore bones, erratic breathing, weariness, anxiety, numbness, skin sensitivity, and weight fluctuations. Because there are higher risks of colon cancer and high blood pressure if the calcium supply is also inadequate, the problem could get worse. P intakes over 3–4 g/day are potentially dangerous since they may prevent the body from absorbing calcium [52].
Calcium: The RDA for calcium (Ca) in the human body is 800-1300 mg/day [45]. The biological processes of several tissues depend on calcium, making it a crucial mineral for human health (parathyroid gland, nervous and cardiac systems, musculoskeletal system, and bones and teeth) [53,54]. Furthermore, Ca helps to maintain mineral homeostasis as well as general physiological performance and can act as a cofactor in enzyme activities (mitochondrial transporter for ATP and fatty acid oxidation) [53,54]. Recent investigations have demonstrated calcium’s function as a second messenger [55]. Ca consumption somewhat lowers colon cancer’s risk. To lower the risk of pre-eclampsia, it is advised that pregnant women consume more calcium [56]. Many circumstances cause additional intake of Ca in the body because of damage to the control mechanisms, including hypercalcemia, which can be caused by increased mobilization of calcium from bone, augmented tubular reabsorption, diminished glomerular purification in the kidneys, or increased dietary intake. Ca levels are subject to homeostatic controls to prevent an unnecessary accumulation in blood tissues [57,58].
Magnesium: Magnesium (Mg) has an RDA of 200-400 mg. This necessary mineral affects insulin post-receptor signaling and vascular smooth muscle tone as a Ca antagonist. As a cofactor of up to 300 enzymes, this mineral has been linked to energy metabolism, neurotransmitter release, endothelial cell activities, and participation in muscle and neuron excitability [59]. Age-related diseases and magnesium insufficiency are linked [60]. The lower magnesium content in the diet can cause insulin resistance, particularly when the deficit is combined with a fructose-enriched diet, which may also raise the risk of developing chronic diseases like metabolic syndrome, diabetes, hypertension, and numerous cardiovascular problems [61]. The most prevalent adverse effects of consuming too much magnesium is hypotension, headaches, vague bone pain, nausea, and abdominal discomfort. Magnesium's toxic consequences are rare [62].
Potassium: The daily consumption rate of Potassium (K) is 3500 mg [45]. K aids nerve functions by upholding the stability of the physical fluid system and assisting nerve functions through its role in nerve impulse transmission. This mineral is also related to muscle retraction and cardiac activity. Cardiac arrhythmias are linked to potassium deficiencies [63]. A lower concentration of Kin serum or hypokalemia is characterized by weakness, exhaustion, and twitching of the muscles [63]. If K in the serum is above 5.5 mmol/L, arrhythmias or hyperkalemia may result. Hyperkalemia includes symptoms like myoglobinuria, rhabdomyolysis, muscle spasms, and weakness [63].
Sodium: The daily sodium (Na) intake recommendation is 2400 mg. A deficit of Na in the body may cause diarrhea, vomiting, sweating, nausea, dizziness, poor focus, muscle weakness, and other symptoms. Surplus Na intake in the body may be caused by increased absorption or as a side effect of kidney disease, resulting in neurological problems and high blood pressure. Excessive Na consumption may result in Ca loss over time [64].
Zinc: The RDA for Zinc (Zn) is 8.0 to 11.0 mg/day. More than 100 enzymes involved in the production of nucleic acids and proteins, cellular development, the utilization of glucose, and the secretion of insulin all need zinc for proper structure and function [65,66]. This mineral is involved in the Zn fingers that are related to DNA, hemoglobin, myoglobin, and cytochromes; whereas other elements, such as Fe or Cu, are present in high concentrations, the bioavailability of these organic compounds, including Zn, is reduced [67,68]. Zn's insufficiency or absence in the body reduces DNA synthesis, sensitivity to taste and smell, and immune system efficacy [67,68]. It was summarized that Zn deficiency in organisms causes hypochromic anemia, hair whiting, and shedding [69]. Both acute and chronic effects are caused by Zn toxicity or overeating. Taking Zn 150–450 mg/day for a long time lowers Cu absorption, transforms Fe, impairs immunological functioning, and lowers HDL levels [70,71].
Iron: Iron (Fe) is an essential element for producing energy in the body. Its dosage daily is 8.0–18 mg/day. The primary cause of iron deficiency is a lower Fe intake than the RDA. Hypochromic anemia develops from severe Fe deficiency [69]. Often, blood transfusions, genetic or metabolic problems, or excessive consumption can all promote toxic Fe levels in the body. In addition, liver and heart diseases, diabetes, and skin abnormalities might be caused by excessive iron intake, as described by Porter and Rawla (2022) [72].
Manganese: Manganese (Mn) acts as an enzyme cofactor in oxidative processes to metabolize glucose [73]. Mn deficiency is commonly rare, but it is associated with reduced levels of cholesterol, abnormalities in red blood cells, and mucopolysaccharide composition. Under controlled conditions, a scaly rash and low plasma cholesterol levels were found [68]. An overabundance of Mn in the brain causes a toxic effect, resulting in a Parkinson-like disease [67,68].
Copper: The RDA for copper (Cu) is 1.0-1.6 mg/day. Major roles are linked to enzyme function, which includes Phase-I detoxifying enzymes (cytochrome C oxidase family of enzymes) [74] (Gupta and Lutsenko, 2009). Furthermore, Cu is required for the development of connective tissue and nerve coverings (myelin sheath) [68] and contributes to Fe metabolism [69]. Cu can be collected in the human body (liver and brain) up to a limit of 80 mg without causing clinical symptoms of toxicity over a short period, supporting insufficient food intake [69]. Although copper deficiency is uncommon in humans, it can cause skeletal abnormalities, normocytic, hypochromic anemia, leucopenia, and neutropenia, among other hematological symptoms [69]. Cu toxicity has been linked to gastrointestinal effects such as cramps, nausea, diarrhea, and vomiting in acute episodes as well as liver damage in chronic overdoses [75].
Selenium: The necessary dosage for selenium (Se) as a micronutrient is 70 g/day. Se is required for the formation of selenoproteins, which are involved in antioxidant processes [76]. It plays a vital role in regulating the activities of the thyroid and immune systems [68]. She has been linked to a significant reduction in the risk of numerous types of cancer [77]. Hypothyroidism, heart disease, and inadequacies of the immune system may be caused by a shortage of selenium [78,79]. Numerous symptoms, like hair loss, gastrointestinal distress, exhaustion, and slight nerve damage, have been linked to an overabundance of selenium. Se toxicity, on the other hand, is uncommon and linked to unintentional exposures [79].
Chromium: The chromium (Cr) RDA is 25–35 g/day. Cr functions as an insulin adjuvant and is necessary for healthy blood glucose and lipid metabolism [80]. Other biochemical functions for Cr have also been identified, including regulation of metabolism, energy production, lipoprotein or lipid synthesis, and participation in gene expression. Cr deficiency symptoms include peripheral neuropathy, glucose intolerance, and weight loss [68]. A lower dosage of Cr in the body may elevate the severity of heart diseases [81]. There is no evidence that Cr is toxic to the body. High Cr doses, on the other hand, have been linked to chromosomal damage, renal and liver changes, and metallic-mineral problems [82].
Cobalt: The RDA for the cobalt (Co) is 300 g per day. Cobalt is required for red blood cell hemopoiesis and anemia prevention [69]. Co influences the physiological roles of vitamin B12, and the creation and maintenance of red blood cells are controlled by their jointly functioning functions (Co and B12). Furthermore, Co excites hunger, growth, and energy release [83]. Excessive cobalt consumption can harm the heart muscles, raise hemoglobin levels, cause heart failure, and affect the thyroid glands' functions [84].
Molybdenum: Molybdenum (Mo) doses of 250 g per day are considered safe. Functions of molybdenum include purine metabolism, amino acid turnover, and the removal of secondary harmful chemicals (nitrosamines) [68]. For oxidizing enzymes, molybdenum acts as a cofactor, particularly for xanthine oxidase and sulfite oxidase [68]. Mo deficiency may be due to a genetic metabolic condition that causes acute neurodegeneration and early childhood death [85]. Mo in excess and toxic amounts might slow down the metabolism of Co and cause anemia-like symptoms [86].

The Medicinal Properties of Wheat on Overall Health

Uses of wheat for metabolic syndrome: “Metabolic syndrome” refers to an imbalance in the human metabolic pattern. Metabolic syndrome may increase cholesterol levels and increase obesity and blood sugar levels while raising the risk of diabetes [87]. Numerous investigations have demonstrated the presence of tocotrienols, ferulic acids, arabinoxylan, and tocopherols in whole wheat [88]. These compounds in wheat may regulate the risk of metabolic syndrome by regulating blood sugar, decreasing blood pressure, and resulting in a healthy body mass index [87].
Use of wheat to improve the immune system: Numerous vitamins and elements included in wheat may help with immunity. Wheat contains dietary fibers and ferulic acid, which can produce T-helper cells, macrophages, and neutrophils that improve the function of immune cells [89].
Use of wheat for cancer treatment: Numerous malignancies can be treated with wheat. Kumar et al. (2017) [12] found that eating foods high in dietary fiber may lower the risk of colon, colorectal, stomach, liver, and pancreatic cancer.
Use of wheat for heart health: Wheat may be beneficial for conditions like myocardial infarction or stroke. High fiber intake may reduce the risk of cardiovascular diseases [90]. A study found that those who consumed a lot of dietary fiber had a lower risk of myocardial infarction [90].
Use of wheat for gallstones: Wheat has high levels of indigestible fibers that may help to avoid gallstones. Researchers have reported that individuals consuming more fiber have a lesser risk of developing gallstones than those who consume less [91].
Use of wheat for tooth disorders: Consuming wheat may reduce the chances of toothache or tooth decay. Although chewing is a must while taking wheat, this may help in the fast movement of teeth and may give proper exercise to the teeth [87].
Use of wheat for constipation: Wheat may be used to produce bowel movements and thereby relieve constipation. In addition, a high amount of fiber in wheat may be helpful for easy movement of stools and may prevent piles [12].
Use of wheat for diabetes: Wheat may have anti-diabetic properties due to the presence of fiber. Studies on rats showed that high fiber intake might lower the blood glucose level [12]. Furthermore, large-scale human studies have shown that dietary fiber consumption may reduce the risk of diabetes [12].

Progress in Improving Nutritional Quality

Nutrients are the compounds in food required by the body to perform its basic functions. Nutritional quality refers to the bioavailability or concentration of desirable nutritional substances for human health, such as carbohydrates, protein, lipids, fiber, vitamins, minerals, and selected phenolic acids found in wheat grain [92].
Nutritional improvement is done mainly in two stages, one at the crop production stage and another at the post-harvest food processing stage [92,93,94,95,96,97,98]. To improve nutrition during the post-harvest food processing stage, various desirable parts of the grain are added to the food. The major functional compounds such as fibers, vitamins, minerals, and phenolics are chiefly concentrated in the bran of wheat grains [12]. Therefore, the addition of the bran part of wheat grain is an effective way to formulate fortified wheat foods in wheat-based food products, but due to the negative effects of bran on dough rheology and the sensory properties of final products [99,100], the consumption of whole grain meals is still below dietary recommendations [101,102]. It was also shown that the addition of bran increases cooking loss, swelling index, and water absorption in pasta products [103,104,105]. Likewise, several studies showed that hard crumb, bitter flavor, and dark color were observed in baked products that had been enriched with wheat bran [105,106,107]. It was concluded that the levels of bran addition should not exceed 20% to obtain products with acceptable sensory qualities [96,97,108]. For the bioavailability of the nutrients upon consumption, a series of processes such as assimilation, accumulation, biosynthesis, translocation, and remobilization are involved [92,109,110,111,112,113]. To improve the nutritional quality of wheat grain, the genotypic and phenotypic characterization of these key biological processes or pathways should be carried out [92]. The application of biofortification is the ultimate method to improve the nutritional quality of wheat or other crops, which is the most sustainable approach that can reach the nutritional requirements of the global community cost-effectively. Biofortification is a process that enhances the dietary bioavailability or concentration of desirable nutritional components in plants genetically [114,115]. The primary information regarding the crop’s genetic and phenotypic profile across different environments is required to apply the biofortification method. Significant progress has been made in efforts to improve the nutritional value of wheat. Conventional and transgenic approaches are being used to improve the nutritional value of wheat.
Generally, in conventional-based approaches, soil and foliar application of specific nutrients and germplasm screening, which contains higher amounts of desired nutrients across different wheat genotypes grown in different environments, are performed to increase nutritional quality in wheat [116]. Much progress has been made to increase the different nutrients in wheat grains. Generally, Zn and Fe concentrations in grains of commercial wheat cultivars are 20–35 mg/kg [116) showing that zinc fertilizers can increase the zinc density in wheat grains. Further, they showed that Fe and Zn accumulation was increased by the application of nitrogen. Cakmak et al. (2010) [116] also showed that positive correlations between grain Zn and protein concentrations were observed under high soil applications of Zn and N. Bharti et al. (2013) [93] demonstrated that soil application of ZnSO4 at 20 kg/ha plus foliar spray of 0.5% ZnSO4 increased grain Zn by 80%, methionine content by 61.3%, and phytic acid by 23.2% in wheat. Zink-amino acid chelates are another important source of Zn and are capable of increasing the nutritional quality of wheat. Ghasemi et al. (2013) [94] showed that foliar application of zinc-amino acid chelates increased 14.3% Zn, Fe, and protein over ZnSO4 application. Waraich et al. (2010) [117] conducted a field experiment to determine wheat response to four irrigation regimes applied at different growth stages and four nitrogen levels of 0, 50, 100, and 150 kg nitrogen (N) per hectare. They also observed that nitrogen application significantly improved grain crude protein at all irrigation levels.
Micronutrients are essential components that promote health. It is crucial to create varieties with increased micronutrient content because the majority of people in the world, especially those in underdeveloped countries, rely on cereal and plant-based diets to meet their micronutrient needs [38]. The two most significant micronutrients are iron and zinc [38]. Due to insufficient genetic variety, the majority of wheat types do not have adequate levels of iron and zinc. Plant breeding for micronutrient concentration started in the 21st century when deficiencies in micronutrients such as iron, iodine, zinc, and vitamins were recognized as an issue of overwhelming global public health significance. To improve the nutritional quality of agricultural products, the Consultative Group on International Agricultural Research (CGIAR) established HarvestPlus in July 2003.
The genetic diversity of the genes in wheat that code for many commercially significant features has been reduced as a result of domestication. Utilizing its wild relatives will expand this genetic diversity. The genus Aegilops, which is its nearest relative, can be a valuable source of novel alleles [39,118]. Tetraploid and hexaploid wheat have greatly benefited from the influence of Aegilops. Kumar et al. (2019) [119] reported that more than 180 lines or accessions of Aegilops have been investigated to increase genetic diversity and overcome this genetic limitation.
Many accessions of Ae. kotschyi, Ae. longissima, Ae. tauschii, Ae. peregrina, Ae. cylindrica, Ae. ventricosa, and Ae. geniculate has been reported to contain increased amounts of iron and zinc in seeds [38,39,118,120,121,122]. A quantitative trait locus (Gpc-B1) from wild emmer wheat has been identified and cloned [123] that is linked to increased levels of grain protein, zinc, and iron, resulting in rapid senescence and higher nutrient mobilization from leaves to the developing grains. Due to the absence of phytases, which break down phytic acid in the digestive tract, monogastric animals such as humans are unable to digest phosphorus, which is stored in the form of phytic acid in plant seeds (including wheat) [124]. Phytase is accumulated in the seeds of transgenic wheat plants that express the Aspergillus niger phytase-encoding gene phyA [125]. Increased bioavailability of Zn2+, Ca 2+, and Fe2+ by breaking down complexes with phytic acid was another achievement in the expression and thermostability of phytases in transgenic wheat plants.
Studies on the phytochemical composition of Aegilops species are rare, with most of the research being done in Europe [119]. But because Aegilops species have such a wide genetic range, it is possible to study various phytochemicals in them, including phenolic acids, carotenoids, tocopherols, alkyl resorcinols, benzoxazinoids, phytosterols, and lignans. Ae. geniculata has been found to have a large number of phenolic diglycerides [119]. A genetic approach was also considered to increase the amount of phenolic acids by evaluating the phenolic content and composition among different wheat species and cultivars [124,126]. Genetic variability for phenolic acids was extensively documented in winter and spring bread-wheat genotypes [127] and, more recently, in a large number of durum wild and cultivated genotypes [113]. It was shown that phenolic acid variation was only partly due to genetic factors, as a strong influence of environmental factors was observed [127,128]. Indeed, more recent evidence on durum genotypes showed a higher ratio of genotypic variance to the total variance, suggesting that it might be realistic to improve phenolic acid content in elite durum wheat germplasm through appropriate breeding programs [113].
Protein is an important nutrient for humans and animals. Unfortunately, cereal proteins are nutritionally incomplete due to their deficiency in several essential amino acids (EAAs) such as lysine (1.5-4.5% vs. 5.5% of the WHO recommendation), tryptophan (Trp, 0.8–2.0% vs. 1.0%), and threonine (Thr, 2.7–3.9% vs. 4.0%) [129]. The protein content of wheat grains may vary from 10% to 18% of the total dry matter. In the past, plant breeders made efforts to improve the quality of plant proteins. They identified natural mutants like high-lysine corn and barley and developed them into elite genotypes [129]. Unfortunately, these mutants were more susceptible to diseases and pests, and lower yields were associated with them. Alternative methods to address these inadequacies are used in modern biotechnology, such as sequence modification of a protein for increased EAAs. This method requires specific protein areas that can be changed without changing the protein's overall structure, stability, or function [129]. The zein protein was altered by inserting Lys-rich (Pro-Lys) residues adjacent to or in place of the -zein's Pro-Xaa region [129]. The modified Lys-rich zeins were found in high concentrations in protein bodies and co-localized with endogenous - and -zeins in the temporarily transformed maize endosperms [129].

Conclusions

One of the most significant and nutritious staple foods in the world is wheat, which is also a strong source of calories. Wheat’s nutritional value can be increased by adding more dietary fiber, protein, and many other phytochemicals including carotenoids and vitamins, as well as micronutrients like Fe and Zn, etc. Its consumption ensures the optimum intake of nutritional values and prevents diseases as it contains medicinal properties. Improving nutrition is a crucial component of wheat research. Future research should focus on identifying other genes and treatments for nutritional quality enhancement. In addition, progress in improving the nutritional quality of wheat should be evaluated.

Author Contributions

MZI and MNA conceptualized the manuscript. MZI, MNA, and AR wrote and revised it. MZI and MMR revised and edited it.

Conflicts of Interest

The authors have no competing interests.

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Table 2. Recommended Daily Allowance of macroelements and microelements for sound human health.
Table 2. Recommended Daily Allowance of macroelements and microelements for sound human health.
Macroelements mg/day Macroelements mg/day Microelements µg/day
Phosphorus 800-1300 Zinc 8-11 Selenium 70.0
Calcium 800-1300 Iron 8-18 Chromium 25-35
Magnesium 200-400 Manganese 2.00 Cobalt 300
Potassium 3500 Copper 1.0-1.6 Molybdenum <250
Sodium 2400 - - Nickel 302-735
[45].
Table 3. Mineral composition of wheat grains (per 100 g).
Table 3. Mineral composition of wheat grains (per 100 g).
Macro elements Amount (mg g-1) Macro elements Amount (µg g-1)
Ca 0.38 Cu 5.26
Mg 1.26 Fe 37.9
K 4.08 Mn 22.5
P 4.12 Zn 38.9
S 1.30 B 1.96
Na 0.14 Se 0.11
- - Mo 1.71
[49].
Table 4. Mineral composition of wheat flour (per 100 g).
Table 4. Mineral composition of wheat flour (per 100 g).
Macro elements (mg g-1)
Ca Mg K P
Avg. Rang Avg. Rang Avg. Rang Avg. Rang
0.27 0.11-1.96 0.35 0.19-0.51 1.71 0.76-3.16 1.92 0.81-7.15
Microelements (µg g-1)
Cu Fe Mn Zn
Avg. Rang Avg. Rang Avg. Rang Avg. Rang
1.84 1.00-2.80 37.8 10.5-146.6 8.2 3.9-14.7 9.4 5.1-13.9
[50].
Table 5. Contents of macroelements and microelements in wheat grains of Triticum sp. (per 100 g).
Table 5. Contents of macroelements and microelements in wheat grains of Triticum sp. (per 100 g).
Wheat species Macroelements (mg g-1) Microelements (µg g-1)
Ca P Mg K Cu Fe Mn Zn
Common wheat (Triticum aestivum) 0.11 5.16 1.04 4.74 2.35 60.8 44.8 28.8
Spelt wheat (Triticum spelta) 0.10 3.71 1.25 5.49 0.71 94.7 62.2 21.9
Emmer wheat (Triticum dicoccon) 0.15 4.73 1.34 5.84 0.66 77.6 47.1 17.8
Einkorn wheat (Triticum monococcum) 0.17 4.74 1.74 6.45 1.40 58.8 32.9 17.8
[46].
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