Version 1
: Received: 25 May 2024 / Approved: 27 May 2024 / Online: 27 May 2024 (10:03:35 CEST)
How to cite:
Han, M. M.; Zhang, Y. Serum Bilirubin Concentrations and Insulin Resistance in Advanced Maternal Age without Diabetes Mellitus. Preprints2024, 2024051725. https://doi.org/10.20944/preprints202405.1725.v1
Han, M. M.; Zhang, Y. Serum Bilirubin Concentrations and Insulin Resistance in Advanced Maternal Age without Diabetes Mellitus. Preprints 2024, 2024051725. https://doi.org/10.20944/preprints202405.1725.v1
Han, M. M.; Zhang, Y. Serum Bilirubin Concentrations and Insulin Resistance in Advanced Maternal Age without Diabetes Mellitus. Preprints2024, 2024051725. https://doi.org/10.20944/preprints202405.1725.v1
APA Style
Han, M. M., & Zhang, Y. (2024). Serum Bilirubin Concentrations and Insulin Resistance in Advanced Maternal Age without Diabetes Mellitus. Preprints. https://doi.org/10.20944/preprints202405.1725.v1
Chicago/Turabian Style
Han, M. M. and Yong Zhang. 2024 "Serum Bilirubin Concentrations and Insulin Resistance in Advanced Maternal Age without Diabetes Mellitus" Preprints. https://doi.org/10.20944/preprints202405.1725.v1
Abstract
Aim: We estimated the correlation between serum bilirubin concentrations and insulin resistance in advanced maternal age without diabetes mellitus. Method: The cross-sectional study involved consecutive 50 women of advanced maternal age without diabetes mellitus, and insulin resistance (IR) was diagnosed according to the homeostatic model assessment insulin resistant (HOMA-IR) formula and the cut-off point was set to more than 2.5. Serum bilirubin and HOMA-IR were compared between the IR (+) and IR (-) groups. Results: We found that serum bilirubin levels in the IR subjects were significantly decreased compared to those without IR (p = 0.0252). Serum bilirubin concentrations were negatively correlated with the weight and the fasting insulin concentrations in all subjects (r=−0.282, p=0.047, r=-0.424, p=0.002). Additionally, serum bilirubin had a negatively correlation with HOMA-IR (r = -0.410, p = 0.003) in all subjects. The multiple linear regression analysis found that serum total bilirubin levels were independently correlated with HOMA-IR (beta = -0.392, p= 0.015) in these subjects. Conclusions: The study demonstrated that serum bilirubin concentrations had negatively correlation with insulin resistance in advanced pregnant women without diabetes mellitus, and decreased serum bilirubin may forebode increased gestational diabetes mellitus risk in our study population.
Keywords
Serum bilirubin; Pregnant women; Insulin resistance; Advanced maternal age
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
