Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination With Anticancer Drugs on the c6 Rat Glioma Model

Gulim K. Mukusheva; Roza I. Jalmakhanbetova; Altynay Zh. Shaibek; Manshuk S. Nurmaganbetova; Aigerym R. Zhasymbekova; Оralgazy A. Nurkenov; Ekaterina A. Akishina; Irina A. Kolesnik; Evgenij A. Dikusar; Tatiana I. Terpinskaya; Vladimir A. Kulchitsky; Vladimir I. Potkin; Alexander L. Pushkarchuk; Dmitry A. Lyakhov; Dominik L. Michels

doi:10.20944/preprints202405.1552.v1

How to cite: Mukusheva, G. K.; Jalmakhanbetova, R. I.; Shaibek, A. Z.; Nurmaganbetova, M. S.; Zhasymbekova, A. R.; Nurkenov, О. A.; Akishina, E. A.; Kolesnik, I. A.; Dikusar, E. A.; Terpinskaya, T. I.; Kulchitsky, V. A.; Potkin, V. I.; Pushkarchuk, A. L.; Lyakhov, D. A.; Michels, D. L. Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination With Anticancer Drugs on the c6 Rat Glioma Model. Preprints 2024, 2024051552. https://doi.org/10.20944/preprints202405.1552.v1 Mukusheva, G. K.; Jalmakhanbetova, R. I.; Shaibek, A. Z.; Nurmaganbetova, M. S.; Zhasymbekova, A. R.; Nurkenov, О. A.; Akishina, E. A.; Kolesnik, I. A.; Dikusar, E. A.; Terpinskaya, T. I.; Kulchitsky, V. A.; Potkin, V. I.; Pushkarchuk, A. L.; Lyakhov, D. A.; Michels, D. L. Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination With Anticancer Drugs on the c6 Rat Glioma Model. Preprints 2024, 2024051552. https://doi.org/10.20944/preprints202405.1552.v1

Abstract

Alkaloid-based urea derivatives were produced with high yield through the reaction of anabasine and cytisine with isoxazolylphenylcarbamates in boiling benzene. Their antitumor ac-tivity in combination with the commonly used six anticancer drugs namely cyclophosphane, fluorouracil, etoposide, cysplatine, ribomustine with different mechanisms of action was investi-gated. Based on the quantum chemical calculations data and molecular docking, hypotheses have been put forward to explain their mutual influence when affecting on the С6 rat glioma model cells.

Keywords

Subject

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Alkaloid-Based Isoxazolylureas: Synthesis and Effect in Combination With Anticancer Drugs on the c6 Rat Glioma Model

Abstract

Keywords

Subject

Comments (0)