Version 1
: Received: 12 May 2024 / Approved: 13 May 2024 / Online: 13 May 2024 (08:29:25 CEST)
How to cite:
Buchynskyi, M.; Oksenych, V.; Kamyshna, I.; Vorobets, I.; Kamyshnyi, O. Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in MAFLD and COVID-19 Outcomes. Preprints2024, 2024050815. https://doi.org/10.20944/preprints202405.0815.v1
Buchynskyi, M.; Oksenych, V.; Kamyshna, I.; Vorobets, I.; Kamyshnyi, O. Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in MAFLD and COVID-19 Outcomes. Preprints 2024, 2024050815. https://doi.org/10.20944/preprints202405.0815.v1
Buchynskyi, M.; Oksenych, V.; Kamyshna, I.; Vorobets, I.; Kamyshnyi, O. Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in MAFLD and COVID-19 Outcomes. Preprints2024, 2024050815. https://doi.org/10.20944/preprints202405.0815.v1
APA Style
Buchynskyi, M., Oksenych, V., Kamyshna, I., Vorobets, I., & Kamyshnyi, O. (2024). Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in MAFLD and COVID-19 Outcomes. Preprints. https://doi.org/10.20944/preprints202405.0815.v1
Chicago/Turabian Style
Buchynskyi, M., Ihor Vorobets and Oleksandr Kamyshnyi. 2024 "Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in MAFLD and COVID-19 Outcomes" Preprints. https://doi.org/10.20944/preprints202405.0815.v1
Abstract
Metabolic-associated fatty liver disease (MAFLD) is a risk factor for severe COVID-19. This study explores the potential influence of gut hormone receptor and immune response gene expression on COVID-19 outcomes in MAFLD patients. Methods: We investigated gene expression levels of AHR, FFAR2, FXR, and TGR5 in patients with MAFLD and COVID-19 compared to controls. We examined associations between gene expression and clinical outcomes. Results: COVID-19 patients displayed altered AHR expression, potentially impacting immune response and recovery. Downregulated AHR in MAFLD patients correlated with increased coagulation parameters. Elevated FFAR2 expression in MAFLD linked to specific immune cell populations and hospital stay duration. Significantly lower FXR expression was observed in both MAFLD and severe COVID-19. Conclusion: Our findings suggest potential modulatory roles for AHR, FFAR2, and FXR in COVID-19 and MAFLD.
Keywords
COVID-19; MAFLD; AHR; FXR; Gene expression
Subject
Medicine and Pharmacology, Clinical Medicine
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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