PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial
Version 1
: Received: 10 May 2024 / Approved: 11 May 2024 / Online: 13 May 2024 (07:49:03 CEST)
How to cite:
Lopresti, A. L.; Smith, S. J.; Riggs, M. L.; Major, R. A.; Gibb, T. G.; Wood, S. M.; Hester, S. N.; Knaggs, H. E. An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Preprints2024, 2024050741. https://doi.org/10.20944/preprints202405.0741.v1
Lopresti, A. L.; Smith, S. J.; Riggs, M. L.; Major, R. A.; Gibb, T. G.; Wood, S. M.; Hester, S. N.; Knaggs, H. E. An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Preprints 2024, 2024050741. https://doi.org/10.20944/preprints202405.0741.v1
Lopresti, A. L.; Smith, S. J.; Riggs, M. L.; Major, R. A.; Gibb, T. G.; Wood, S. M.; Hester, S. N.; Knaggs, H. E. An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Preprints2024, 2024050741. https://doi.org/10.20944/preprints202405.0741.v1
APA Style
Lopresti, A. L., Smith, S. J., Riggs, M. L., Major, R. A., Gibb, T. G., Wood, S. M., Hester, S. N., & Knaggs, H. E. (2024). An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial. Preprints. https://doi.org/10.20944/preprints202405.0741.v1
Chicago/Turabian Style
Lopresti, A. L., Shelly N Hester and Helen E Knaggs. 2024 "An Examination into the Effects of a Nutraceutical Supplement on Cognition, Stress, Eye Health, and Skin Satisfaction in Adults with Self-Reported Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Trial" Preprints. https://doi.org/10.20944/preprints202405.0741.v1
Abstract
Background: Dietary quality and the consumption of antioxidant-rich foods has been shown to protect against memory decline. Therefore, this double-blind, randomized, placebo-controlled study aimed to investigate the effects of a nutritional supplement on changes in cognitive performance. Methods: In adults aged 40 to 70 years with subjective memory complaints, participants were randomly allocated to take a supplement containing vitamin E, astaxanthin, and grape juice extract daily for 12 weeks or a matching placebo. The primary outcomes comprised changes in cognitive tasks assessing episodic memory, working memory, and verbal memory. Secondary and exploratory measures included changes in the speed of information processing, attention, and self-report measures of memory, stress, and eye and skin health. Moreover, changes in plasma concentrations of brain-derived neurotrophic factor, malondialdehyde, tumor-necrosis factor-α, and interleukin-6 were measured, along with changes in skin carotenoid concentrations. Results: compared to the placebo, nutritional supplementation was associated with larger improvements in episodic memory, a self-report measure of everyday memory, increased plasma brain-derived neurotrophic factor, decreased plasma malondialdehyde, and increased skin carotenoid concentrations. However, there were no group differences in changes in the remaining outcome measures. Conclusions: Twelve weeks of supplementation with a nutritional supplement was associated with improvements in episodic memory and several biological markers associated with cognitive health. Future research will be essential to extend and validate the current findings.
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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