Communication
Version 1
Preserved in Portico This version is not peer-reviewed
New Strategies in the Control of Graves’ Disease
Version 1
: Received: 29 April 2024 / Approved: 30 April 2024 / Online: 1 May 2024 (02:30:35 CEST)
How to cite: Seo, S.; Abalo-Lojo, J. M.; Vazquez-Lago, J. M. New Strategies in the Control of Graves’ Disease. Preprints 2024, 2024050001. https://doi.org/10.20944/preprints202405.0001.v1 Seo, S.; Abalo-Lojo, J. M.; Vazquez-Lago, J. M. New Strategies in the Control of Graves’ Disease. Preprints 2024, 2024050001. https://doi.org/10.20944/preprints202405.0001.v1
Abstract
Graves' disease (GD) is an autoimmune disorder in which Thyrotropin Receptor Antibodies (TRAb) continuously stimulate thyroid receptors, leading to excessive production of thyroid hormones. TRAb also affect the orbital tissues, causing Graves' ophthalmopathy. Treatment to control Graves' disease consists of antithyroid drugs, radioiodine and thyroidectomy, and through such treatments, TRAb is reduced and the disease is alleviated. The mechanism by which TRAb, which play a critical role in the pathogenesis of Graves’ disease, decreases after GD treatment is still unknown. This paper presents a theoretical mechanism of how GD patients maintain a vicious cycle and how GD treatment can reduce the TRAb levels and breaks the cycle using stress-based ideas.
Keywords
Graves' disease; hyperthyroidism; Graves' ophthalmopathy; antithyroid drugs; stress
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Comments (0)
We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.
Leave a public commentSend a private comment to the author(s)
* All users must log in before leaving a comment
