Version 1
: Received: 29 April 2024 / Approved: 30 April 2024 / Online: 30 April 2024 (11:23:33 CEST)
How to cite:
Giannopoulos, A.; Mohammad, A.; Retsidou, M. I.; Tucker, J. A.; Bornath, D. P.; McCarthy, S. F.; MacPherson, R. E. K.; Hazell, T. J.; Klentrou, P. Pre and Postmenopausal Females Have Different Inflammatory Cytokine and BDNF Responses to High-Intensity Interval Training Exercise. Preprints2024, 2024041997. https://doi.org/10.20944/preprints202404.1997.v1
Giannopoulos, A.; Mohammad, A.; Retsidou, M. I.; Tucker, J. A.; Bornath, D. P.; McCarthy, S. F.; MacPherson, R. E. K.; Hazell, T. J.; Klentrou, P. Pre and Postmenopausal Females Have Different Inflammatory Cytokine and BDNF Responses to High-Intensity Interval Training Exercise. Preprints 2024, 2024041997. https://doi.org/10.20944/preprints202404.1997.v1
Giannopoulos, A.; Mohammad, A.; Retsidou, M. I.; Tucker, J. A.; Bornath, D. P.; McCarthy, S. F.; MacPherson, R. E. K.; Hazell, T. J.; Klentrou, P. Pre and Postmenopausal Females Have Different Inflammatory Cytokine and BDNF Responses to High-Intensity Interval Training Exercise. Preprints2024, 2024041997. https://doi.org/10.20944/preprints202404.1997.v1
APA Style
Giannopoulos, A., Mohammad, A., Retsidou, M. I., Tucker, J. A., Bornath, D. P., McCarthy, S. F., MacPherson, R. E. K., Hazell, T. J., & Klentrou, P. (2024). Pre and Postmenopausal Females Have Different Inflammatory Cytokine and BDNF Responses to High-Intensity Interval Training Exercise. Preprints. https://doi.org/10.20944/preprints202404.1997.v1
Chicago/Turabian Style
Giannopoulos, A., Tom J Hazell and Panagiota Klentrou. 2024 "Pre and Postmenopausal Females Have Different Inflammatory Cytokine and BDNF Responses to High-Intensity Interval Training Exercise" Preprints. https://doi.org/10.20944/preprints202404.1997.v1
Abstract
The responses of inflammatory cytokines and brain-derived neurotrophic factor (BDNF) to a high-intensity interval training (HIIT) session were compared between 7 postmenopausal (57±2 y) and 8 premenopausal females (44±3 y) during the luteal phase of their menstrual cycle, when estrogen and progesterone are highest, and. HIIT consisted of 10 x 1 min running intervals (90% maximum heart rate) separated by 1 min recovery intervals. Blood samples were collected at baseline (fasted), pre-exercise (postprandial), and 0, 30 and 90 min post-HIIT and analyzed for interleukin (IL-6) and 10 (IL-10), tumour necrosis factor-alpha (TNF-α) and BDNF. IL-6 significantly increased from pre-exercise to 0 min post-HIIT in postmenopausal (+40%, p=0.01) but 30 min post-HIIT in premenopausal females (+60%, p=0.02). IL-6 remained elevated at 90 min post-HIIT in premenopausal (+104%, p=0.05) and to a higher degree in postmenopausal (+385%, p<0.001). IL-10 showed no response. TNF-α increased from pre- to 0 min post-HIIT (+10%, p=0.05), then decreased to below pre-exercise at 30 min (-10%, p=0.02) and 90 min (-5%, p=0.04) in both groups. BDNF increased immediate post-HIIT in premenopausal (+60%, p<0.001) but not postmenopausal females. The differences in IL-6 and BDNF response to HIIT between pre and postmenopausal females provide evidence of the role of female reproductive hormones in the regulation of these exercise-induced responses.
Biology and Life Sciences, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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