PreprintArticleVersion 1Preserved in Portico This version is not peer-reviewed
Poly-L-Lactic Acid Scaffolds Additivated with Rosmarinic Acid: A Multi-Analytical Approach to Assess the Morphology, Thermal Behavior, and Hydrophilicity
Version 1
: Received: 25 April 2024 / Approved: 26 April 2024 / Online: 28 April 2024 (08:15:24 CEST)
How to cite:
Schiera, V.; Carfi Pavia, F.; La Carrubba, V.; Brucato, V.; Dintcheva, N.T. Poly-L-Lactic Acid Scaffolds Additivated with Rosmarinic Acid: A Multi-Analytical Approach to Assess the Morphology, Thermal Behavior, and Hydrophilicity. Preprints2024, 2024041744. https://doi.org/10.20944/preprints202404.1744.v1
Schiera, V.; Carfi Pavia, F.; La Carrubba, V.; Brucato, V.; Dintcheva, N.T. Poly-L-Lactic Acid Scaffolds Additivated with Rosmarinic Acid: A Multi-Analytical Approach to Assess the Morphology, Thermal Behavior, and Hydrophilicity. Preprints 2024, 2024041744. https://doi.org/10.20944/preprints202404.1744.v1
Schiera, V.; Carfi Pavia, F.; La Carrubba, V.; Brucato, V.; Dintcheva, N.T. Poly-L-Lactic Acid Scaffolds Additivated with Rosmarinic Acid: A Multi-Analytical Approach to Assess the Morphology, Thermal Behavior, and Hydrophilicity. Preprints2024, 2024041744. https://doi.org/10.20944/preprints202404.1744.v1
APA Style
Schiera, V., Carfi Pavia, F., La Carrubba, V., Brucato, V., & Dintcheva, N.T. (2024). Poly-L-Lactic Acid Scaffolds Additivated with Rosmarinic Acid: A Multi-Analytical Approach to Assess the Morphology, Thermal Behavior, and Hydrophilicity. Preprints. https://doi.org/10.20944/preprints202404.1744.v1
Chicago/Turabian Style
Schiera, V., Valerio Brucato and Nadka Tz. Dintcheva. 2024 "Poly-L-Lactic Acid Scaffolds Additivated with Rosmarinic Acid: A Multi-Analytical Approach to Assess the Morphology, Thermal Behavior, and Hydrophilicity" Preprints. https://doi.org/10.20944/preprints202404.1744.v1
Abstract
This study aims to demonstrate the possibility of incorporating a natural antioxidant biomolecule, into polymeric porous scaffolds. To this end, Poly-L-Lactic Acid (PLLA) scaffolds were produced using the Thermally Induced Phase Separation (TIPS) technique and additivated with different amounts of Rosmarinic Acid (RA). The scaffolds, with a diameter of 4 mm and a thickness of 2 mm, were characterized with a multi-analytical approach. Specifically, Scanning Electron Mi-croscopy analyses demonstrated the presence of an interconnected porous network, character-ized by a layer of RA at the level of the pore’s surfaces. Moreover, the presence of RA biomole-cules increased the hydrophilic nature of the sample, as evidenced by the decrease in contact angle with water from 128° to 76°. This approach is cost-effective, and it could be customized with different biomolecules, offering the possibility of producing porous polymeric structures con-taining antioxidant molecules. These scaffolds meet the requirements of tissue engineering and could be offered a potential solution to reduce inflammation associated with scaffold implantation thus improving tissue regeneration.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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