Teixeira Palla Braga, N.; Vilela Antunes, J.M.; Colosimo, E.A.; Alves Dias, V.M.; Januário, J.N.; Novato Silva, I. Impact of lowering TSH cut-off on neonatal screening for congenital hypothyroidism in Minas Gerais, Brazil. Preprints2024, 2024041219. https://doi.org/10.20944/preprints202404.1219.v1
APA Style
Teixeira Palla Braga, N., Vilela Antunes, J.M., Colosimo, E.A., Alves Dias, V.M., Januário, J.N., & Novato Silva, I. (2024). Impact of lowering TSH cut-off on neonatal screening for congenital hypothyroidism in Minas Gerais, Brazil. Preprints. https://doi.org/10.20944/preprints202404.1219.v1
Chicago/Turabian Style
Teixeira Palla Braga, N., José Nélio Januário and Ivani Novato Silva. 2024 "Impact of lowering TSH cut-off on neonatal screening for congenital hypothyroidism in Minas Gerais, Brazil" Preprints. https://doi.org/10.20944/preprints202404.1219.v1
Abstract
A higher incidence of primary congenital hypothyroidism (CH) has been related to in-creased sensitivity in neonatal screening tests. The benefit of treatment in mild cases remains a topic of debate. We evaluated the cost-benefit of reducing the blood-spot TSH cut-off (b-TSH) from 10 (Group 2) to 6 mIU/L (Group 1) in a public neonatal screening program. During the study period, 40% of 123 newborns with CH (n= 162,730; incidence = 1:1,323) had b-TSH between 6 and 10 mIU/L. Group 1 patients had fewer clinical symptoms (p=0.02), lower serum TSH (p
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
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