Version 1
: Received: 16 April 2024 / Approved: 17 April 2024 / Online: 17 April 2024 (13:26:32 CEST)
How to cite:
Shibato, J.; Takenoya, F.; Kimura, A.; Yamashita, M.; Hirako, S.; Rakwal, R.; Shioda, S. DNA Microarray and Bioinformatic Analysis Reveals the Potential of Whale Oil in Enhancing Hair Growth in a C57BL/6 Mice Model. Preprints2024, 2024041154. https://doi.org/10.20944/preprints202404.1154.v1
Shibato, J.; Takenoya, F.; Kimura, A.; Yamashita, M.; Hirako, S.; Rakwal, R.; Shioda, S. DNA Microarray and Bioinformatic Analysis Reveals the Potential of Whale Oil in Enhancing Hair Growth in a C57BL/6 Mice Model. Preprints 2024, 2024041154. https://doi.org/10.20944/preprints202404.1154.v1
Shibato, J.; Takenoya, F.; Kimura, A.; Yamashita, M.; Hirako, S.; Rakwal, R.; Shioda, S. DNA Microarray and Bioinformatic Analysis Reveals the Potential of Whale Oil in Enhancing Hair Growth in a C57BL/6 Mice Model. Preprints2024, 2024041154. https://doi.org/10.20944/preprints202404.1154.v1
APA Style
Shibato, J., Takenoya, F., Kimura, A., Yamashita, M., Hirako, S., Rakwal, R., & Shioda, S. (2024). DNA Microarray and Bioinformatic Analysis Reveals the Potential of Whale Oil in Enhancing Hair Growth in a C57BL/6 Mice Model. Preprints. https://doi.org/10.20944/preprints202404.1154.v1
Chicago/Turabian Style
Shibato, J., Randeep Rakwal and Seiji Shioda. 2024 "DNA Microarray and Bioinformatic Analysis Reveals the Potential of Whale Oil in Enhancing Hair Growth in a C57BL/6 Mice Model" Preprints. https://doi.org/10.20944/preprints202404.1154.v1
Abstract
Much research has been conducted to determine how hair regeneration is regulated, as this could provide therapeutic, cosmetic, and even psychological interventions for hair loss. The current study focused on the hair growth effect and effective utilization of fatty oil obtained from Bryde's whales through high-throughput DNA microarray approach in conjunction with immunohistochemical observations. The research also examined the mechanisms and factors involved in hair growth. In an experiment using female C57BL/6J mice, the vehicle control group (VC: propylene glycol: ethanol: water), the positive control group (MXD: 3% minoxidil), and the experimental group (WO: 20% Whale Oil) were topically applied to the back of the mouse. The results showed that 3% MXD and 20% WO were more effective than VC in promoting hair growth, especially 20% WO. Furthermore, in hematoxylin and eosin-stained skin tissue, an increase in the number of hair follicles and subcutaneous tissue thickness was observed with 20% WO. Whole-genome transcriptomic analysis also showed that 20% WO may have lower stress- and inflammation-related responses than 3% MXD. Therefore, whale oil can be expected to be used as a safe hair growth agent.
Keywords
DNA microarray; oil; minoxidil; hair growth; immunostaining; animal model
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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