Andreu-Ballester, J.C.; Galindo-Regal, L.; Cuéllar, C.; López-Chuliá, F.; García-Ballesteros, C.; Fernández-Murga, L.; Llombart-Cussac, A.; Domínguez-Márquez, M.V. A Low Number of Baselines γδ T Cells increases the Risk of SARS-CoV-2 Post-Vaccination Infection. Vaccines2024, 12, 553.
Andreu-Ballester, J.C.; Galindo-Regal, L.; Cuéllar, C.; López-Chuliá, F.; García-Ballesteros, C.; Fernández-Murga, L.; Llombart-Cussac, A.; Domínguez-Márquez, M.V. A Low Number of Baselines γδ T Cells increases the Risk of SARS-CoV-2 Post-Vaccination Infection. Vaccines 2024, 12, 553.
Andreu-Ballester, J.C.; Galindo-Regal, L.; Cuéllar, C.; López-Chuliá, F.; García-Ballesteros, C.; Fernández-Murga, L.; Llombart-Cussac, A.; Domínguez-Márquez, M.V. A Low Number of Baselines γδ T Cells increases the Risk of SARS-CoV-2 Post-Vaccination Infection. Vaccines2024, 12, 553.
Andreu-Ballester, J.C.; Galindo-Regal, L.; Cuéllar, C.; López-Chuliá, F.; García-Ballesteros, C.; Fernández-Murga, L.; Llombart-Cussac, A.; Domínguez-Márquez, M.V. A Low Number of Baselines γδ T Cells increases the Risk of SARS-CoV-2 Post-Vaccination Infection. Vaccines 2024, 12, 553.
Abstract
Background: The effectiveness of the anti-COVID-19 vaccine remains a matter to be clarified.
Methods: The humoral and cellular immunity after the administration of three doses of the Pfizer–BioNTech and Oxford AstraZeneca vaccines against SARS-CoV-2 over one year and the appearance of post-vaccination COVID-19 have been studied.
Results: Anti-SARS-CoV-2 IgG and IgA antibodies showed a progressive increase throughout the vaccination period. This increase was greatest after the third dose. The highest levels were observed in subjects who had anti-SARS-CoV-2 antibodies prior to vaccination. There was an increase in CD4+ αβ, CD8+ γδ and TEM CD8+ γδ T cells, and a decrease in apoptosis in CD4+CD8+ and CD56+ αβ and γδ T cells. Post-vaccination SARS-CoV-2 infection was greater than 60%. The symptoms of COVID-19 were very mild and were related to γδ T cell deficit, specifically CD8+ TEMRA and CD56+ γδ TEM, as well as lower pre-vaccine apoptosis levels.
Conclusions: Those results demonstrate the important role that γδ T cells play in SARS-CoV-2 vaccine immunization.
Keywords
SARS-CoV-2; vaccine; antibodies; αβ T cells; γδ T cells
Subject
Medicine and Pharmacology, Immunology and Allergy
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.