Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Emerging Roles of Exosomes in Stroke Therapy

Version 1 : Received: 12 April 2024 / Approved: 15 April 2024 / Online: 15 April 2024 (09:46:38 CEST)

A peer-reviewed article of this Preprint also exists.

Larson, A.; Natera-Rodriguez, D.E.; Crane, A.; Larocca, D.; Low, W.C.; Grande, A.W.; Lee, J. Emerging Roles of Exosomes in Stroke Therapy. Int. J. Mol. Sci. 2024, 25, 6507. Larson, A.; Natera-Rodriguez, D.E.; Crane, A.; Larocca, D.; Low, W.C.; Grande, A.W.; Lee, J. Emerging Roles of Exosomes in Stroke Therapy. Int. J. Mol. Sci. 2024, 25, 6507.

Abstract

Stroke is the number one cause of morbidity in the United States and number two cause of death worldwide. There is a critical unmet medical need for more effective treatments of ischemic stroke, and this need is increasing with the shift in demographics to an older population. Recently, several studies have reported the therapeutic potential of stem cell derived exosomes as new candidates for cell-free treatment in stoke. This review focuses on the use of stem cell-derived exosomes as a potential treatment tool for stroke patients. Therapy using exosomes can have a clear clinical advantage over stem cell transplantation in terms of safety, cost, and convenience, as well as reducing bench-to-bed latency due to fewer regulatory milestones. In this review article, we focus on 1) the therapeutic potential of exosomes in stroke treatment, 2) the optimization process of upstream and downstream production, and 3) preclinical application in stroke animal model. Finally, we discuss the limitations and challenges faced by exosome therapy in future clinical applications.

Keywords

stroke; exosomes; stem cells; stroke therapy

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.