Version 1
: Received: 10 April 2024 / Approved: 10 April 2024 / Online: 11 April 2024 (13:59:17 CEST)
How to cite:
Chen, A.; Lai, S.; Lu, C.; Chen, K. Explore the Molecular Mechanism of Caveolae-1 Regulates Changes in Blood-Brain Barrier Permeability Leading to Eosinophilic Meningoencephalitis. Preprints2024, 2024040762. https://doi.org/10.20944/preprints202404.0762.v1
Chen, A.; Lai, S.; Lu, C.; Chen, K. Explore the Molecular Mechanism of Caveolae-1 Regulates Changes in Blood-Brain Barrier Permeability Leading to Eosinophilic Meningoencephalitis. Preprints 2024, 2024040762. https://doi.org/10.20944/preprints202404.0762.v1
Chen, A.; Lai, S.; Lu, C.; Chen, K. Explore the Molecular Mechanism of Caveolae-1 Regulates Changes in Blood-Brain Barrier Permeability Leading to Eosinophilic Meningoencephalitis. Preprints2024, 2024040762. https://doi.org/10.20944/preprints202404.0762.v1
APA Style
Chen, A., Lai, S., Lu, C., & Chen, K. (2024). Explore the Molecular Mechanism of Caveolae-1 Regulates Changes in Blood-Brain Barrier Permeability Leading to Eosinophilic Meningoencephalitis. Preprints. https://doi.org/10.20944/preprints202404.0762.v1
Chicago/Turabian Style
Chen, A., Cheng-You Lu and Ke-Min Chen. 2024 "Explore the Molecular Mechanism of Caveolae-1 Regulates Changes in Blood-Brain Barrier Permeability Leading to Eosinophilic Meningoencephalitis" Preprints. https://doi.org/10.20944/preprints202404.0762.v1
Abstract
Angiostrongylus cantonensis, a zoonotic parasite, can invade the human central nervous system (CNS) and cause acute eosinophilic meningitis or eosinophilic meningoencephalitis. Mice infected with A. cantonensis show elevated levels of pro-inflammatory cytokines, plasminogen activators, and matrix metalloproteinase-9, resulting in disruption of the blood-brain barrier (BBB) and immune cell infiltration into the CNS. Caveolin-1 (Cav-1) regulates the permeability of the BBB, which affects immune cells and cerebrospinal fluid. This intricate interaction ultimately fuels the progression of brain damage and edema. This study aims to investigate the regulatory role of Cav-1 in the pathogenesis of meningoencephalitis induced by A. cantonensis infection. We investigate pathological alterations by triphenyl-tetrazolium chloride, brain water content, BBB permeability, Western blot analysis, and gelatin zymography in BALB/c mice after A. cantonensis. The study evaluates the critical role of Cav-1 regulation through the TLR4 / MyD88 signaling pathway, modulates tight junction proteins, influences BBB permeability, and contributes to brain damage in A. cantonensis-induced meningoencephalitis.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
