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Dietary Supplementation of Pistacia lentiscus: Hepato‐Protective Potential Against 7,12‐ dimethylbenz(a)anthracene Carcinogen in C57Bl/6 Mice, Alongside In Vitro Anti‐Cancer Efficacy
ABIDI, O.; Hammami, I.; Jebali, J.; Srairi-Abid, N.; Alqahtani, A.S.; Gressier, B.; Eto, B.; SOUILEM, O. Dietary Supplementation of Pistacia lentiscus: Hepato‐Protective Potential Against 7,12‐ dimethylbenz(a)anthracene Carcinogen in C57Bl/6 Mice, Alongside In Vitro Anti‐Cancer Efficacy. Preprints2024, 2024040726. https://doi.org/10.20944/preprints202404.0726.v1
APA Style
ABIDI, O., Hammami, I., Jebali, J., Srairi-Abid, N., Alqahtani, A.S., Gressier, B., Eto, B., & SOUILEM, O. (2024). Dietary Supplementation of <em>Pistacia lentiscus</em>: Hepato‐Protective Potential Against 7,12‐ dimethylbenz(a)anthracene Carcinogen in C57Bl/6 Mice, Alongside In Vitro Anti‐Cancer Efficacy. Preprints. https://doi.org/10.20944/preprints202404.0726.v1
Chicago/Turabian Style
ABIDI, O., Bruno Eto and Ouajdi SOUILEM. 2024 "Dietary Supplementation of <em>Pistacia lentiscus</em>: Hepato‐Protective Potential Against 7,12‐ dimethylbenz(a)anthracene Carcinogen in C57Bl/6 Mice, Alongside In Vitro Anti‐Cancer Efficacy" Preprints. https://doi.org/10.20944/preprints202404.0726.v1
Abstract
The pervasive presence of atmospheric pollution, particularly polycyclic aromatic hydrocarbons such as 7,12-dimethylbenz(a)anthracene, instigates aberrant cellular and tissue conditions, precipitating oxidative damage and inflammatory cascades conducive to the onset of cancer, notably mammary cancer. Given the hepatic metabolism of 7,12-dimethylbenz(a)anthracene, the imperative of employing natural antioxidants becomes apparent. In this study, we delve into the antioxidant and hepato-protective properties of Pistacia lentiscus against 7,12-dimethylbenz(a)anthracene-induced toxicity, alongside exploring its potential anticancer attributes. Our investigations unveil Pistacia lentiscus's anti-proliferative efficacy against human breast cancer cell lines. Notably, 7,12-dimethylbenz(a)anthracene-intoxication escalates body weight, disrupts lipid profiles, and incites serum oxidative damage. Concurrently, hepatic and renal oxidative stress ensue, accompanied by heightened antioxidant enzyme activity in the 7,12-dimethylbenz(a)anthracene-exposed-group compared to controls (p<0.05). Nonetheless, Pistacia lentiscus co-administration rectifies biochemical imbalances, significantly attenuates oxidative stress aberrations, and augments antioxidant enzyme responses (p<0.05). Importantly, histological analysis evinces Pistacia lentiscus's shielding effect against 7,12-dimethylbenz(a)anthracene induced hepatocyte injury and steatosis. Our findings underscore Pistacia lentiscus's robust anti-proliferative, antioxidant, and hepato-protective capacities, mitigating metabolic disturbances, oxidative stress propagation in liver and kidney functions, and potential histological alterations, thereby impeding 7,12-dimethylbenz(a)anthracene-induced mammary cancer initiation. We posit that Pistacia lentiscus may serve as a prophylactic agent against breast cancer instigated by this carcinogen.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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