Version 1
: Received: 9 April 2024 / Approved: 10 April 2024 / Online: 10 April 2024 (10:56:20 CEST)
How to cite:
Carrera Marcolin, L.; Cuñé Castellana, J.; Martí Melero, L.; de Lecea, C.; Tintoré Gazulla, M. Synergistic effect of postbiotic yeast ABB C22® on gut in-flammation, barrier function and protection from Rotavirus in-fection. Preprints2024, 2024040696. https://doi.org/10.20944/preprints202404.0696.v1
Carrera Marcolin, L.; Cuñé Castellana, J.; Martí Melero, L.; de Lecea, C.; Tintoré Gazulla, M. Synergistic effect of postbiotic yeast ABB C22® on gut in-flammation, barrier function and protection from Rotavirus in-fection. Preprints 2024, 2024040696. https://doi.org/10.20944/preprints202404.0696.v1
Carrera Marcolin, L.; Cuñé Castellana, J.; Martí Melero, L.; de Lecea, C.; Tintoré Gazulla, M. Synergistic effect of postbiotic yeast ABB C22® on gut in-flammation, barrier function and protection from Rotavirus in-fection. Preprints2024, 2024040696. https://doi.org/10.20944/preprints202404.0696.v1
APA Style
Carrera Marcolin, L., Cuñé Castellana, J., Martí Melero, L., de Lecea, C., & Tintoré Gazulla, M. (2024). Synergistic effect of postbiotic yeast ABB C22® on gut in-flammation, barrier function and protection from Rotavirus in-fection. Preprints. https://doi.org/10.20944/preprints202404.0696.v1
Chicago/Turabian Style
Carrera Marcolin, L., Carlos de Lecea and Maria Tintoré Gazulla. 2024 "Synergistic effect of postbiotic yeast ABB C22® on gut in-flammation, barrier function and protection from Rotavirus in-fection" Preprints. https://doi.org/10.20944/preprints202404.0696.v1
Abstract
Diarrhoea is a serious cause of mortality worldwide that can lead to dehydration, gut barrier function impairment, nutrient malabsorption, and alterations of the gut microbiota (dysbiosis). Current solutions for its management, such as oral rehydration salts (ORS), inhibitors of the gut motility, antibiotics, and living probiotics only partially counteract the mechanisms of the disease and do not provide a full coverage of the problem. Potential risks of the use of living probiotic strains, particularly in immunocompromised patients, can be eliminated with the use of tyndallized (heat-killed) postbiotic bacteria and yeast. ABB C22® is a postbiotic combination of three tyndallized yeasts, namely Saccharomyces boulardii, Saccharomyces cerevisiae, and Kluyveromyces marxianus. To assess the action of the postbiotic combination on diarrhoea, immune and gut epithelial cell signaling assays, gut barrier formation assay and rotavirus gene expression assay were performed. ABB C22® showed a strong anti-inflammatory effect, an induction of the build-up of the gut epithelium, and a degree of protection against rotavirus infection. These experimental studies support the use of the postbiotic ABB C22® as a solution for the management of diarrhoea and gastrointestinal conditions, alone or in combination with existing but incomplete treatments.
Keywords
diarrhoea; postbiotic; yeast; inflammation; gut protection; Rotavirus
Subject
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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