Inflammaging: Expanding the Molecular Palette of Cellular Immunophenotype

Dmitry O. Ivanov; Anna O. Drobintseva; Valeriia R. Rodichkina; Ekaterina S. Mironova; Tatiana S. Zubareva; Yulia S. Krylova; Svetlana N. Morozkina; Ruslan A. Nasyrov; Igor M. Kvetnoy

doi:10.20944/preprints202404.0644.v1

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preprints.org > medicine and pharmacology > obstetrics and gynaecology > doi: 10.20944/preprints202404.0644.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Inflammaging: Expanding the Molecular Palette of Cellular Immunophenotype

Dmitry O. Ivanov

Anna O. Drobintseva

^* ,

Valeriia R. Rodichkina

Ekaterina S. Mironova

Tatiana S. Zubareva

Yulia S. Krylova

Svetlana N. Morozkina

Ruslan A. Nasyrov

Igor M. Kvetnoy

Version 1 : Received: 8 April 2024 / Approved: 9 April 2024 / Online: 9 April 2024 (11:49:25 CEST)

How to cite: Ivanov, D.O.; Drobintseva, A.O.; Rodichkina, V.R.; Mironova, E.S.; Zubareva, T.S.; Krylova, Y.S.; Morozkina, S.N.; Nasyrov, R.A.; Kvetnoy, I.M. Inflammaging: Expanding the Molecular Palette of Cellular Immunophenotype. Preprints 2024, 2024040644. https://doi.org/10.20944/preprints202404.0644.v1 Ivanov, D.O.; Drobintseva, A.O.; Rodichkina, V.R.; Mironova, E.S.; Zubareva, T.S.; Krylova, Y.S.; Morozkina, S.N.; Nasyrov, R.A.; Kvetnoy, I.M. Inflammaging: Expanding the Molecular Palette of Cellular Immunophenotype. Preprints 2024, 2024040644. https://doi.org/10.20944/preprints202404.0644.v1

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MDPI and ACS Style

Ivanov, D.O.; Drobintseva, A.O.; Rodichkina, V.R.; Mironova, E.S.; Zubareva, T.S.; Krylova, Y.S.; Morozkina, S.N.; Nasyrov, R.A.; Kvetnoy, I.M. Inflammaging: Expanding the Molecular Palette of Cellular Immunophenotype. Preprints 2024, 2024040644. https://doi.org/10.20944/preprints202404.0644.v1

APA Style

Ivanov, D.O., Drobintseva, A.O., Rodichkina, V.R., Mironova, E.S., Zubareva, T.S., Krylova, Y.S., Morozkina, S.N., Nasyrov, R.A., & Kvetnoy, I.M. (2024). Inflammaging: Expanding the Molecular Palette of Cellular Immunophenotype. Preprints. https://doi.org/10.20944/preprints202404.0644.v1

Chicago/Turabian Style

Ivanov, D.O., Ruslan A. Nasyrov and Igor M. Kvetnoy. 2024 "Inflammaging: Expanding the Molecular Palette of Cellular Immunophenotype" Preprints. https://doi.org/10.20944/preprints202404.0644.v1

Abstract

Cellular aging is considered as one of the main factors leading to female infertility. The process called “inflammaging”, which was proposed by C. Franceschi in 2014 is characterized by chronic asymptomatic inflammation state resulting to whole body aging and age-associated diseases. In this work the inflammaging model was developed; markers expression associated with SASP (senescence associated secretory phenotype) and cell aging were verified in endometrial cells; the correlation analysis with the known inflammaging markers was done; as well as the age dynamic of markers expression in the groups of young reproductive age and late reproductive age was evaluated. For the first time, the comparative study of the expression of the key signalling molecules involved in the mechanisms of the aging was carried out: IL-6, IL-8, IL-1a, MMP3, SIRT1,6, TERF-1, CALR in endometrial cells in the age aspect and under the influence of the genotoxic stress. The SASP phenotype characterizing the phenomenon of inflammaging can be significantly expanded by the including of the studied molecules - SIRT-1, SIRT-6, TERF, CALR, that we demonstrated for the first time. These signalling molecules may be new therapeutic targets for the age-associated female reproductive system diseases treatment.

Keywords

aging; inflammation; endometrium cells; molecular markers; molecular targets

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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