Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Cracking the Code: Investigating the Correlation between Aerobic Vaginitis and Preterm Labor

Panagiota Zarmakoupi
,
Alexandros Psarris
ORCID logo ,
Christina Karasmani
* ORCID logo ,
Panagiotis Antsaklis
ORCID logo ,
Marianna Theodora
ORCID logo ,
Michael Syndos
,
Andreas Pampanos
ORCID logo ,
Kalliopi I. Pappa
,
Ekaterini Domali
ORCID logo ,
Nikolaos Thomakos
,
Karolina Akinosoglou
ORCID logo ,
Aristotelis Tsiakalos
,
George Daskalakis
ORCID logo
Version 1 : Received: 8 April 2024 / Approved: 9 April 2024 / Online: 9 April 2024 (13:04:17 CEST)

A peer-reviewed article of this Preprint also exists.

Zarmakoupi, P.; Psarris, A.; Karasmani, C.; Antsaklis, P.; Theodora, M.; Syndos, M.; Pampanos, A.; Pappa, K.I.; Domali, E.; Thomakos, N.; Akinosoglou, K.; Tsiakalos, A.; Daskalakis, G. Cracking the Code: Investigating the Correlation between Aerobic Vaginitis and Preterm Labor. Medicina 2024, 60, 648. Zarmakoupi, P.; Psarris, A.; Karasmani, C.; Antsaklis, P.; Theodora, M.; Syndos, M.; Pampanos, A.; Pappa, K.I.; Domali, E.; Thomakos, N.; Akinosoglou, K.; Tsiakalos, A.; Daskalakis, G. Cracking the Code: Investigating the Correlation between Aerobic Vaginitis and Preterm Labor. Medicina 2024, 60, 648.

Abstract

Aerobic vaginitis (AV) is a distinct clinical entity characterized by inflammation and abnormal vaginal microflora. Often mistaken for bacterial vaginosis, AV remains relatively unknown and underdiagnosed. AV's understanding is evolving, with some experts suggesting it may primarily be an immunological disorder, the prevalence of which ranges from 7-13% in non-pregnant women and 4.1-8.3% during pregnancy. Pregnancy can affect susceptibility to vaginal infections, leading to adverse outcomes for the woman and the newborn. This review summarizes the correlation between AV and adverse pregnancy outcomes, particularly preterm birth, the leading cause of morbidity and mortality among neonates. Improved understanding of AV's impact on pregnancy outcomes can lead to early recognition, proper management, and effective interventions. While some studies support an association between AV and preterm labor, the existing knowledge of this relationship remains limited. The evidence suggests that AV may contribute to adverse pregnancy outcomes, mainly preterm birth, but further research is needed to establish a definitive link. Further studies are needed to investigate the underlying mechanisms and clarify AV's role in premature labor. A comprehensive understanding of AV's impact on pregnancy outcomes is crucial for early recognition, appropriate management, and effective interventions.

Keywords

Aerobic vaginitis; desquamative aerobic vaginitis; pregnancy outcomes; preterm labor

Subject

Medicine and Pharmacology, Obstetrics and Gynaecology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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