Version 1
: Received: 8 April 2024 / Approved: 9 April 2024 / Online: 9 April 2024 (12:49:15 CEST)
How to cite:
Du, J.; Wang, Z. Regulation of RIPK1 Phosphorylation: Implications for Inflammation, Cell Death, and Therapeutic Interventions. Preprints2024, 2024040639. https://doi.org/10.20944/preprints202404.0639.v1
Du, J.; Wang, Z. Regulation of RIPK1 Phosphorylation: Implications for Inflammation, Cell Death, and Therapeutic Interventions. Preprints 2024, 2024040639. https://doi.org/10.20944/preprints202404.0639.v1
Du, J.; Wang, Z. Regulation of RIPK1 Phosphorylation: Implications for Inflammation, Cell Death, and Therapeutic Interventions. Preprints2024, 2024040639. https://doi.org/10.20944/preprints202404.0639.v1
APA Style
Du, J., & Wang, Z. (2024). Regulation of RIPK1 Phosphorylation: Implications for Inflammation, Cell Death, and Therapeutic Interventions. Preprints. https://doi.org/10.20944/preprints202404.0639.v1
Chicago/Turabian Style
Du, J. and Zhigao Wang. 2024 "Regulation of RIPK1 Phosphorylation: Implications for Inflammation, Cell Death, and Therapeutic Interventions" Preprints. https://doi.org/10.20944/preprints202404.0639.v1
Abstract
Receptor-interacting protein kinase 1 (RIPK1) plays a crucial role in controlling inflammation and cell death. Its function is tightly controlled through post-translational modifications, enabling its dynamic switch between promoting cell survival and triggering cell death. Phosphorylation of RIPK1 at various sites serves as a critical mechanism for regulating its activity, exerting either activating or inhibitory effects. Perturbations in RIPK1 phosphorylation status have profound implications for the development of severe inflammatory diseases in humans. This review explores the intricate regulation of RIPK1 phosphorylation and dephosphorylation and highlights the potential of targeting RIPK1 phosphorylation as a promising therapeutic strategy for mitigating human diseases.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
