Version 1
: Received: 3 April 2024 / Approved: 4 April 2024 / Online: 4 April 2024 (10:12:43 CEST)
How to cite:
Alkhazaali, Z.; Sahab-Negah, S.; Boroumand, A.R.; Afshari, J.T. MicroRNAs (miRNAs) as Biomarkers for Diagnosis, Prognosis, or as Therapeutics Molecules in Neurodegenerative Diseases. Preprints2024, 2024040366. https://doi.org/10.20944/preprints202404.0366.v1
Alkhazaali, Z.; Sahab-Negah, S.; Boroumand, A.R.; Afshari, J.T. MicroRNAs (miRNAs) as Biomarkers for Diagnosis, Prognosis, or as Therapeutics Molecules in Neurodegenerative Diseases. Preprints 2024, 2024040366. https://doi.org/10.20944/preprints202404.0366.v1
Alkhazaali, Z.; Sahab-Negah, S.; Boroumand, A.R.; Afshari, J.T. MicroRNAs (miRNAs) as Biomarkers for Diagnosis, Prognosis, or as Therapeutics Molecules in Neurodegenerative Diseases. Preprints2024, 2024040366. https://doi.org/10.20944/preprints202404.0366.v1
APA Style
Alkhazaali, Z., Sahab-Negah, S., Boroumand, A.R., & Afshari, J.T. (2024). MicroRNAs (miRNAs) as Biomarkers for Diagnosis, Prognosis, or as Therapeutics Molecules in Neurodegenerative Diseases. Preprints. https://doi.org/10.20944/preprints202404.0366.v1
Chicago/Turabian Style
Alkhazaali, Z., Amir Reza Boroumand and Jalil Tavakol Afshari. 2024 "MicroRNAs (miRNAs) as Biomarkers for Diagnosis, Prognosis, or as Therapeutics Molecules in Neurodegenerative Diseases" Preprints. https://doi.org/10.20944/preprints202404.0366.v1
Abstract
Neurodegenerative diseases that include Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), Parkinson's disease (PD), Huntington's disease (HD), and multiple sclerosis (MS), arise due to numerous causes like protein accumulation and autoimmunity, characterized by neurologic depletion which lead to incapacity in normal physiological function such as thinking and movement in these patients. Glial cells perform a critical role in protective neuronal function; in the case of neuroinflammation, glial cell dysfunction can promote the development of neurodegenerative diseases. MiRNA participates in gene regulation and plays a vital role in many biological processes in the body; in the central nervous system (CNS), it can play an essential part in neural maturation and differentiation. In neurodegenerative diseases, miRNA dysregulation occurs, enhancing the development of these diseases. In this review, we discuss neurodegenerative diseases (Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS)) and how miRNA is preserved as a diagnostic biomarker or therapeutic agent in these disorders. Finally, we highlighted miRNA as therapy.
Keywords
Microglia cell; neurodegenerative disease; miRNA; protein accumulation
Subject
Medicine and Pharmacology, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
