Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

High PGC-1α Expression as a Poor Prognostic Indicator in Intracranial Glioma

Yu-Wen Cheng
ORCID logo ,
Jia-Hau Lee
,
Chih-Hui Chang
,
Tzu-Ting Tseng
,
Chee-Yin Chai
,
Ann-Shung Lieu
* ,
Aij-Lie Kwan
*
Version 1 : Received: 2 April 2024 / Approved: 3 April 2024 / Online: 4 April 2024 (17:26:13 CEST)

A peer-reviewed article of this Preprint also exists.

Cheng, Y.-W.; Lee, J.-H.; Chang, C.-H.; Tseng, T.-T.; Chai, C.-Y.; Lieu, A.-S.; Kwan, A.-L. High PGC-1α Expression as a Poor Prognostic Indicator in Intracranial Glioma. Biomedicines 2024, 12, 979. Cheng, Y.-W.; Lee, J.-H.; Chang, C.-H.; Tseng, T.-T.; Chai, C.-Y.; Lieu, A.-S.; Kwan, A.-L. High PGC-1α Expression as a Poor Prognostic Indicator in Intracranial Glioma. Biomedicines 2024, 12, 979.

Abstract

Gliomas are the most common primary brain tumors in adults. Despite multidisciplinary treatment approaches, the survival rates for patients with malignant glioma have only improved marginally, and few prognostic biomarkers have been identified. Peroxisome proliferator-activated receptor γ (PPARγ) coactivator-1α (PGC-1α) is a crucial regulator of cancer metabolism, playing a vital role in cancer cell adaptation to fluctuating energy demands. In this study, the clinicopathological roles of PGC-1α in gliomas were evaluated. Employing immunohistochemistry, cell culture, siRNA transfection, cell viability assays, western blot analyses, and in vitro and in vivo invasion and migration assays, we explored the functions of PGC-1α in glioma progression. High PGC-1α expression was significantly associated with an advanced pathological stage in patients with glioma and with poorer overall survival. The downregulation of PGC-1α inhibited glioma cell proliferation, invasion, and migration and altered the expression of oncogenic markers. These results conclusively demonstrated that PGC-1α plays a critical role in maintaining the malignant phenotype of glioma cells and indicated that targeting PGC-1α could be an effective strategy to curb glioma progression and improve patient survival outcomes.

Keywords

glioma; PGC-1α; prognosis

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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