Version 1
: Received: 1 April 2024 / Approved: 1 April 2024 / Online: 2 April 2024 (16:19:45 CEST)
How to cite:
Reyes, R.; Rodriguez-Muñoz, R.; Nahmad, M. Cell Recruitment and the Origin of Anterior-Posterior Asymmetry in the Drosophila Wing. Preprints2024, 2024040173. https://doi.org/10.20944/preprints202404.0173.v1
Reyes, R.; Rodriguez-Muñoz, R.; Nahmad, M. Cell Recruitment and the Origin of Anterior-Posterior Asymmetry in the Drosophila Wing. Preprints 2024, 2024040173. https://doi.org/10.20944/preprints202404.0173.v1
Reyes, R.; Rodriguez-Muñoz, R.; Nahmad, M. Cell Recruitment and the Origin of Anterior-Posterior Asymmetry in the Drosophila Wing. Preprints2024, 2024040173. https://doi.org/10.20944/preprints202404.0173.v1
APA Style
Reyes, R., Rodriguez-Muñoz, R., & Nahmad, M. (2024). Cell Recruitment and the Origin of Anterior-Posterior Asymmetry in the <em>Drosophila</em> Wing. Preprints. https://doi.org/10.20944/preprints202404.0173.v1
Chicago/Turabian Style
Reyes, R., Rafael Rodriguez-Muñoz and Marcos Nahmad. 2024 "Cell Recruitment and the Origin of Anterior-Posterior Asymmetry in the <em>Drosophila</em> Wing" Preprints. https://doi.org/10.20944/preprints202404.0173.v1
Abstract
The mechanisms underlying the establishment of asymmetric structures during development remain elusive. The wing of Drosophila is asymmetric along the Anterior-Posterior (AP) axis, despite that its growth signals that drive its growth are presumably symmetric. Here, we investigated the contribution of cell recruitment, a process that drives wing fate differentiation in Drosophila, to the asymmetric shape and pattern of the adult wing. Genetic impairment of cell recruitment results in a significant reduction in adult wing asymmetry, primarily affecting the region between longitudinal vein 5 and the wing margin (L5-M). Morphometric analysis reveals that the lack of cell recruitment results in a more symmetric wing with respect to the AP, suggesting a contribution of cell recruitment to the establishment of asymmetry in the adult wing. A close examination of the expression of the wing selector gene vestigial (vg) in wing disc does not support this hypothesis. However, the circularity of the Vg pattern significantly increase in recruitment-impaired wing disc, suggesting that while the decrease of the L5-M region in the adult wing may not be attributed to cell recruitment, it could contribute to the overall asymmetry of the adult wing. We conclude that cell recruitment, a widespread mechanism that participates in growth and patterning of several developing systems, could drive, at least partially, the asymmetric shape of the Drosophila wing.
Biology and Life Sciences, Cell and Developmental Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
