Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Differential Diagnosis of Solid Pancreatic Lesions Using Detective Flow Imaging Endoscopic Ultrasonography

Haruo Miwa
* ORCID logo ,
Kazuya Sugimori
,
Shoichiro Yonei
,
Hayato Yoshimura
,
Kazuki Endo
,
Ritsuko Oishi
,
Akihiro Funaoka
,
Hiromi Tsuchiya
,
Takashi Kaneko
,
Kazushi Numata
,
Shin Maeda
Version 1 : Received: 28 March 2024 / Approved: 28 March 2024 / Online: 29 March 2024 (05:17:37 CET)

A peer-reviewed article of this Preprint also exists.

Miwa, H.; Sugimori, K.; Yonei, S.; Yoshimura, H.; Endo, K.; Oishi, R.; Funaoka, A.; Tsuchiya, H.; Kaneko, T.; Numata, K.; Maeda, S. Differential Diagnosis of Solid Pancreatic Lesions Using Detective Flow Imaging Endoscopic Ultrasonography. Diagnostics 2024, 14, 882. Miwa, H.; Sugimori, K.; Yonei, S.; Yoshimura, H.; Endo, K.; Oishi, R.; Funaoka, A.; Tsuchiya, H.; Kaneko, T.; Numata, K.; Maeda, S. Differential Diagnosis of Solid Pancreatic Lesions Using Detective Flow Imaging Endoscopic Ultrasonography. Diagnostics 2024, 14, 882.

Abstract

Differential diagnosis of solid pancreatic lesions (SPLs) using B-mode endoscopic ultrasonography (EUS) is challenging. Detective flow imaging (DFI) offers the potential for detecting low-flow vessels in the pancreas, thus enhancing diagnostic accuracy. This study aimed to investigate DFI-EUS findings of SPLs and analyze their differential diagnostic accuracy for pancreatic cancer. This retrospective study included patients with pathologically confirmed SPLs who underwent EUS between April 2021 and June 2023. Expert endosonographers, blinded to the patients’ clinical data, evaluated images obtained through B-mode, eFLOW, and DFI-EUS. Frame rate and vessel detection sensitivity between eFLOW and DFI were compared, and diagnostic criteria for pancreatic cancer were established. This study included 104 patients, most diagnosed with pancreatic cancer. DFI-EUS demonstrated a significantly higher vessel visualization rate (96%) in SPLs compared to eFLOW (27%). Additionally, DFI showed a superior frame rate, sensitivity (99%), and accuracy (88%) in detecting pancreatic cancer, although with a modest specificity (43%). On DFI-EUS, characteristics such as hypovascular, peritumoral, or spotty vessel findings were suggestive of pancreatic cancer. DFI-EUS significantly improved the visualization of vascular structures within the SPLs, highlighting its efficacy as a diagnostic modality for pancreatic cancer.

Keywords

Detective Flow Imaging; Pancreatic Cancer; Endoscopic Ultrasonography

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.