Repurposing Castanea sativa By-Product Extract as a Potent Anti-inflammatory Agent

Luisa Frusciante; Michela Geminiani; Tommaso Olmastroni; Pierfrancesco Mastroeni; Alfonso Trezza; Laura Salvini; Stefania Lamponi; Ottavia Spiga; Annalisa Santucci

doi:10.20944/preprints202403.1600.v1

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preprints.org > biology and life sciences > life sciences > doi: 10.20944/preprints202403.1600.v1

Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Repurposing Castanea sativa By-Product Extract as a Potent Anti-inflammatory Agent

Luisa Frusciante

Michela Geminiani

^* ,

Tommaso Olmastroni

Pierfrancesco Mastroeni

Version 1 : Received: 25 March 2024 / Approved: 26 March 2024 / Online: 26 March 2024 (12:53:41 CET)

How to cite: Frusciante, L.; Geminiani, M.; Olmastroni, T.; Mastroeni, P.; Trezza, A.; Salvini, L.; Lamponi, S.; Spiga, O.; Santucci, A. Repurposing Castanea sativa By-Product Extract as a Potent Anti-inflammatory Agent. Preprints 2024, 2024031600. https://doi.org/10.20944/preprints202403.1600.v1 Frusciante, L.; Geminiani, M.; Olmastroni, T.; Mastroeni, P.; Trezza, A.; Salvini, L.; Lamponi, S.; Spiga, O.; Santucci, A. Repurposing Castanea sativa By-Product Extract as a Potent Anti-inflammatory Agent. Preprints 2024, 2024031600. https://doi.org/10.20944/preprints202403.1600.v1

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MDPI and ACS Style

Frusciante, L.; Geminiani, M.; Olmastroni, T.; Mastroeni, P.; Trezza, A.; Salvini, L.; Lamponi, S.; Spiga, O.; Santucci, A. Repurposing Castanea sativa By-Product Extract as a Potent Anti-inflammatory Agent. Preprints 2024, 2024031600. https://doi.org/10.20944/preprints202403.1600.v1

APA Style

Frusciante, L., Geminiani, M., Olmastroni, T., Mastroeni, P., Trezza, A., Salvini, L., Lamponi, S., Spiga, O., & Santucci, A. (2024). Repurposing Castanea sativa By-Product Extract as a Potent Anti-inflammatory Agent. Preprints. https://doi.org/10.20944/preprints202403.1600.v1

Chicago/Turabian Style

Frusciante, L., Ottavia Spiga and Annalisa Santucci. 2024 "Repurposing Castanea sativa By-Product Extract as a Potent Anti-inflammatory Agent" Preprints. https://doi.org/10.20944/preprints202403.1600.v1

Abstract

The “circular bioeconomy” offers numerous opportunities for the health, cosmetic, and nutrition sectors through the potential reuse of Castanea sativa by-products. This abundant and sustainable resource provides valuable bioactive secondary metabolites with antioxidants and anti-inflammatory properties. The transformation of these by-products into high-value products for human health can contribute to sustainable economic growth and reduce the environmental impact of traditional waste disposal practices, thus creating added value from previously underutilized resources. In the present study, we investigated the antioxidant capacity, phytochemical composition and in vitro antioxidant and anti-inflammatory activity of C. sativa burrs (CSB) aqueous extract. The spectrophotometric study yielded optimal total phenolic content (TPC) values, along with significant antioxidant and anti-radical properties. The utilization of UPLC-MS-MS techniques for phytochemical investigation resulted in the identification of a total of 56 metabolites, providing confirmation of the presence of phenolic compounds in CSB. In addition, CSB significantly downregulated pro-inflammatory mediators in LPS-stimulated RAW 264.7 macrophage cells without significant cell toxicity.

Keywords

Castanea sativa; waste repurposing; polyphenols; UPLC-MS-MS; inflammation; RAW 264.7; molecular modeling; docking simulations

Subject

Biology and Life Sciences, Life Sciences

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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