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Evaluation of Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantations in ALS Patients by Investigating Patient's Specific Immunological and Biochemical Biomarkers: A Retrospective study.
Version 1
: Received: 26 March 2024 / Approved: 26 March 2024 / Online: 26 March 2024 (09:15:36 CET)
How to cite:
Alkhazaali, Z.; Sahab-Negah, S.; Boroumand, A.R.; Kaffash, N.; Khodadoust, M.A.; Afshari, J.T. Evaluation of Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantations in ALS Patients by Investigating Patient's Specific Immunological and Biochemical Biomarkers: A Retrospective study.. Preprints2024, 2024031574. https://doi.org/10.20944/preprints202403.1574.v1
Alkhazaali, Z.; Sahab-Negah, S.; Boroumand, A.R.; Kaffash, N.; Khodadoust, M.A.; Afshari, J.T. Evaluation of Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantations in ALS Patients by Investigating Patient's Specific Immunological and Biochemical Biomarkers: A Retrospective study.. Preprints 2024, 2024031574. https://doi.org/10.20944/preprints202403.1574.v1
Alkhazaali, Z.; Sahab-Negah, S.; Boroumand, A.R.; Kaffash, N.; Khodadoust, M.A.; Afshari, J.T. Evaluation of Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantations in ALS Patients by Investigating Patient's Specific Immunological and Biochemical Biomarkers: A Retrospective study.. Preprints2024, 2024031574. https://doi.org/10.20944/preprints202403.1574.v1
APA Style
Alkhazaali, Z., Sahab-Negah, S., Boroumand, A.R., Kaffash, N., Khodadoust, M.A., & Afshari, J.T. (2024). Evaluation of Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantations in ALS Patients by Investigating Patient's Specific Immunological and Biochemical Biomarkers: A Retrospective study.. Preprints. https://doi.org/10.20944/preprints202403.1574.v1
Chicago/Turabian Style
Alkhazaali, Z., Mohammad Ali Khodadoust and Jalil Tavakol Afshari. 2024 "Evaluation of Safety and Efficacy of Repeated Mesenchymal Stem Cell Transplantations in ALS Patients by Investigating Patient's Specific Immunological and Biochemical Biomarkers: A Retrospective study." Preprints. https://doi.org/10.20944/preprints202403.1574.v1
Abstract
Background: Amyotrophic lateral sclerosis (ALS) is an incurable disease. There are no defined valid biomarkers for evaluating therapeutic outcomes of this disease. Numerous approaches have been made to meet this impact. Stem cells, one of these approaches, that might give various hopeful results that can be interpreted as a treatment for ALS This study aims to evaluate Mesenchymal Stem Cell (MSC) therapy as a promising novel treatment modality by estimating some parameters, such as immunological and biochemical factors. Methods: This study course involved 15 confirmed patients with ALS and was designed as an open-label, one-arm retrospective study to evaluate potential diagnostic biomarkers of repeated infusions of autologous bone marrow-derived mesenchymal stem cells (BM-MSC) administered at a dose of 1×106cells/kg BW with 1-month interval, in equal amounts in both intravenous (IV) and intrathecal (IT) simultaneously, by various biochemical and immunological parameters were evaluated during the three-month follow-up period. Results: Our study indicated that in the case of Immunological biomarkers ,Tumor Necrosis Factor-alpha (TNF-α) levels in the Cerebrospinal fluid (CSF) showed a significant decrease at month three after transplantation compared to levels at month zero, and the P-value was (P<0.01). No statistically significant changes were observed for other immunological and biochemical parameters and P-value (P>0.05). Conclusions: These results can indicate the benefit of stem cell transfusion in patients with ALS and suggest some diagnostic biomarkers. Several studies are required to approve these results.
Biology and Life Sciences, Neuroscience and Neurology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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