Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Healing Potential of the Marine Polysaccharides Carrageenan and Ulvan on Second Degree Burns

Dimitra Statha
,
Asimina Papaioannou
,
Stefanos Kikionis
ORCID logo ,
Maria Kostaki
,
Ioannis Sfiniadakis
,
Andreas Vitsos
ORCID logo ,
Jane Anastassopoulou
,
Efstathia Ioannou
ORCID logo ,
Vassilios Roussis
ORCID logo ,
Michail Christou Rallis
* ORCID logo
Version 1 : Received: 22 March 2024 / Approved: 22 March 2024 / Online: 25 March 2024 (09:06:13 CET)

How to cite: Statha, D.; Papaioannou, A.; Kikionis, S.; Kostaki, M.; Sfiniadakis, I.; Vitsos, A.; Anastassopoulou, J.; Ioannou, E.; Roussis, V.; Rallis, M.C. Healing Potential of the Marine Polysaccharides Carrageenan and Ulvan on Second Degree Burns. Preprints 2024, 2024031421. https://doi.org/10.20944/preprints202403.1421.v1 Statha, D.; Papaioannou, A.; Kikionis, S.; Kostaki, M.; Sfiniadakis, I.; Vitsos, A.; Anastassopoulou, J.; Ioannou, E.; Roussis, V.; Rallis, M.C. Healing Potential of the Marine Polysaccharides Carrageenan and Ulvan on Second Degree Burns. Preprints 2024, 2024031421. https://doi.org/10.20944/preprints202403.1421.v1

Abstract

The bioactive marine sulfated polysaccharides ulvan and carrageenan, formulated in gels at 1.5, 5.0 and 10% w/w concentrations, were evaluated for their wound healing potential on second-degree burn wounds. The polysaccharide-based gels were administered on the burn-inflamed skin of hairless female SKH-hr2 mice, and the therapeutic effect of the various treatments was assessed based on histopathological analysis, the clinical condition of mice, photo-documentation, evaluation of biophysical skin parameters, and FT-IR spectroscopy.Clinical and histopathological assessment, as well as the reduction rate of the burn wound area, indicated that the 10% w/w carrageenan gel significantly enhanced wound healing, especially at the early stages of the healing process, recovering both the α-helix of collagen and the glycosaminoglycans configuration as evidenced by the FT-IR absorption bandsof skin in vivo and ex vivo. At later stages, the healing effect of the 5% w/w ulvan gel was also notably significant, indicating that carrageenan and ulvan wound dressing gels could potentially contribute to the efficient wound healing of burn wounds.

Keywords

second-degree burn; mice; carrageenan; ulvan; wound healing

Subject

Medicine and Pharmacology, Dermatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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