PreprintReviewVersion 1Preserved in Portico This version is not peer-reviewed
Exploring the Effect of Acute and Regular Physical Exercise on Brain-Derived Neurotrophic Factor Levels in Individuals with Obesity: A Comprehensive Systematic Review and Meta-Analysis
Version 1
: Received: 21 March 2024 / Approved: 22 March 2024 / Online: 23 March 2024 (09:37:41 CET)
How to cite:
Ceylan, H.İ.; Silva, A.F.; Ramírez-Campillo, R.; Murawska-Ciałowicz, E. Exploring the Effect of Acute and Regular Physical Exercise on Brain-Derived Neurotrophic Factor Levels in Individuals with Obesity: A Comprehensive Systematic Review and Meta-Analysis. Preprints2024, 2024031400. https://doi.org/10.20944/preprints202403.1400.v1
Ceylan, H.İ.; Silva, A.F.; Ramírez-Campillo, R.; Murawska-Ciałowicz, E. Exploring the Effect of Acute and Regular Physical Exercise on Brain-Derived Neurotrophic Factor Levels in Individuals with Obesity: A Comprehensive Systematic Review and Meta-Analysis. Preprints 2024, 2024031400. https://doi.org/10.20944/preprints202403.1400.v1
Ceylan, H.İ.; Silva, A.F.; Ramírez-Campillo, R.; Murawska-Ciałowicz, E. Exploring the Effect of Acute and Regular Physical Exercise on Brain-Derived Neurotrophic Factor Levels in Individuals with Obesity: A Comprehensive Systematic Review and Meta-Analysis. Preprints2024, 2024031400. https://doi.org/10.20944/preprints202403.1400.v1
APA Style
Ceylan, H.İ., Silva, A.F., Ramírez-Campillo, R., & Murawska-Ciałowicz, E. (2024). Exploring the Effect of Acute and Regular Physical Exercise on Brain-Derived Neurotrophic Factor Levels in Individuals with Obesity: A Comprehensive Systematic Review and Meta-Analysis. Preprints. https://doi.org/10.20944/preprints202403.1400.v1
Chicago/Turabian Style
Ceylan, H.İ., Rodrigo Ramírez-Campillo and Eugenia Murawska-Ciałowicz. 2024 "Exploring the Effect of Acute and Regular Physical Exercise on Brain-Derived Neurotrophic Factor Levels in Individuals with Obesity: A Comprehensive Systematic Review and Meta-Analysis" Preprints. https://doi.org/10.20944/preprints202403.1400.v1
Abstract
This investigation aimed to explore the impact of acute and regular physical exercise on Brain-Derived Neurotrophic Factor (BDNF) levels in individuals with obesity. Using the Population, Intervention, Comparator, Outcome, and Study design (PICOS) approach, the inclusion criteria were defined as follows: i) population - individuals with overweight or obesity of any age or gender; ii) intervention - acute or chronic interventions involving aerobic or anaerobic methodologies; iii) comparator - for acute effect studies, pre- and post-evaluations served as comparators, while interventions included at least one experimental group or the inclusion of a control group; iv) outcome - BDNF variability concerning the applied methodology; v) study design - restricted to experimental studies exclusively. Conducted in August 2022, the searches were carried out on PubMed, Academic Search Complete, and Web of Science. The risk of bias was assessed using the Risk of Bias in Non-randomized Studies (RoBANS) tool. Out of 98 potentially relevant articles, 16 met the eligibility criteria, encompassing 23 trials. Substantial heterogeneity was observed for both acute (I2 = 80.4%) and long-term effects (I2 = 88.7%). Additionally, RoBANS analysis indicated a low risk of bias for the included studies. The study's findings revealed a significant increase in the concentration of circulating BDNF in individuals with obesity compared to the control group following acute exercise. However, such an effect was not evident in the context of long-term physical exercise, with a small effect size (ES = 0.49) recorded in the latter scenario. The observed significant increase in BDNF levels post-acute exercise suggests a potential acute response mechanism contributing to the intricate interplay between exercise and neurotrophic factors in this population. Nevertheless, the absence of a similar effect in the context of long-term physical exercise implies a potential adaptation or ceiling effect. These findings underscore the importance of considering both the duration and nature of exercise interventions when exploring the neurobiological responses associated with obesity and exercise. The study provides valuable insights for future research and clinical implications in understanding the nuanced relationship between exercise, neurotrophic factors, and obesity.
Keywords
Obesity; BDNF; physical exercise; meta-analysis
Subject
Medicine and Pharmacology, Endocrinology and Metabolism
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.